CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

Tumor-associated macrophages can account for up to 50% of the tumor mass in breast cancer patients and high TAM density is associated with poor clinical prognosis. Because TAMs enhance tumor growth, development, and metastatic potential, redirection of TAM activation may have significant therapeutic...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149600
Hauptverfasser:	Ball, Michael S, Shipman, Emilie P, Kim, Hyunjung, Liby, Karen T, Pioli, Patricia A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antigens Biology and Life Sciences Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies CD163 antigen CD80 antigen Cell activation Cell Proliferation - drug effects Cytokines Cytokines - genetics Cytokines - metabolism Development and progression Endothelial cells Female Flow cytometry Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Gynecology Health aspects Histocompatibility antigen HLA Humans Interleukin 10 Interleukin 6 Lymphocytes Lymphocytes T Macrophage Activation - drug effects Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Medical research Medicine Medicine and Health Sciences Metastases Metastasis Mice Obstetrics Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Physiological aspects Prognosis Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Studies T-Lymphocytes - cytology Tumor necrosis factor Tumor necrosis factor-α Tumors Vascular endothelial growth factor Vascularization
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