Frailty Markers and Treatment Decisions in Patients Seen in Oncogeriatric Clinics: Results from the ASRO Pilot Study
Comprehensive Geriatric Assessment (CGA) is the gold standard to help oncologists select the best cancer treatment for their older patients. Some authors have suggested that the concept of frailty could be a more useful approach in this population. We investigated whether frailty markers are associa...
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| creator | Farcet, Anaïs de Decker, Laure Pauly, Vanessa Rousseau, Frédérique Bergman, Howard Molines, Catherine Retornaz, Frédérique |
| description | Comprehensive Geriatric Assessment (CGA) is the gold standard to help oncologists select the best cancer treatment for their older patients. Some authors have suggested that the concept of frailty could be a more useful approach in this population. We investigated whether frailty markers are associated with treatment recommendations in an oncogeriatric clinic.
This prospective study included 70 years and older patients with solid tumors and referred for an oncogeriatric assessment. The CGA included nine domains: autonomy, comorbidities, medication, cognition, nutrition, mood, neurosensory deficits, falls, and social status. Five frailty markers were assessed (nutrition, physical activity, energy, mobility, and strength). Patients were categorized as Frail (three or more frailty markers), pre-frail (one or two frailty markers), or not-frail (no frailty marker). Treatment recommendations were classified into two categories: standard treatment with and without any changes and supportive/palliative care. Multiple logistic regression models were used to analyze factors associated with treatment recommendations.
217 patients, mean age 83 years (± Standard deviation (SD) 5.3), were included. In the univariate analysis, number of frailty markers, grip strength, physical activity, mobility, nutrition, energy, autonomy, depression, Eastern Cooperative Oncology Group Scale of Performance Status (ECOG-PS), and falls were significantly associated with final treatment recommendations. In the multivariate analysis, the number of frailty markers and basic Activities of Daily Living (ADL) were significantly associated with final treatment recommendations (p |
| doi_str_mv | 10.1371/journal.pone.0149732 |
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This prospective study included 70 years and older patients with solid tumors and referred for an oncogeriatric assessment. The CGA included nine domains: autonomy, comorbidities, medication, cognition, nutrition, mood, neurosensory deficits, falls, and social status. Five frailty markers were assessed (nutrition, physical activity, energy, mobility, and strength). Patients were categorized as Frail (three or more frailty markers), pre-frail (one or two frailty markers), or not-frail (no frailty marker). Treatment recommendations were classified into two categories: standard treatment with and without any changes and supportive/palliative care. Multiple logistic regression models were used to analyze factors associated with treatment recommendations.
217 patients, mean age 83 years (± Standard deviation (SD) 5.3), were included. In the univariate analysis, number of frailty markers, grip strength, physical activity, mobility, nutrition, energy, autonomy, depression, Eastern Cooperative Oncology Group Scale of Performance Status (ECOG-PS), and falls were significantly associated with final treatment recommendations. In the multivariate analysis, the number of frailty markers and basic Activities of Daily Living (ADL) were significantly associated with final treatment recommendations (p<0.001 and p = 0.010, respectively).
Frailty markers are associated with final treatment recommendations in older cancer patients. Longitudinal studies are warranted to better determine their use in a geriatric oncology setting.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149732</identifier><identifier>PMID: 26918947</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Activities of daily living ; Aged, 80 and over ; Ambulatory Care Facilities ; Autonomy ; Biology and Life Sciences ; Biomarkers - metabolism ; Cancer ; Cancer patients ; Care and treatment ; Clinical Decision-Making ; Cognition ; Correlation analysis ; Decision making ; Drugs ; Economics and Finance ; Emotions ; Energy ; Exercise ; Female ; Frail Elderly ; Frailty ; Geriatric Assessment ; Geriatric nursing ; Grip strength ; Group dynamics ; Human health and pathology ; Humanities and Social Sciences ; Humans ; Life Sciences ; Longitudinal studies ; Male ; Markers ; Medical decision making ; Medicine and Health Sciences ; Mental depression ; Methods ; Mobility ; Mood ; Mortality ; Multivariate analysis ; Neoplasms - metabolism ; Neoplasms - physiopathology ; Neoplasms - therapy ; Nutrition ; Patients ; Physical activity ; Physiological aspects ; Pilot Projects ; Prospective Studies ; Psychiatrics and mental health ; Psychology ; Regression analysis ; Regression models ; Santé publique et épidémiologie ; Social classes ; Social interactions ; Social status ; Solid tumors ; Tumors</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149732-e0149732</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Farcet et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2016 Farcet et al 2016 Farcet et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c726t-4052f7852204bc34412b78b2a96f7b5351648f20c20911f174f533fbc67ac5683</citedby><cites>FETCH-LOGICAL-c726t-4052f7852204bc34412b78b2a96f7b5351648f20c20911f174f533fbc67ac5683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769181/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769181/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27321,27901,27902,33751,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26918947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01482501$$DView record in HAL$$Hfree_for_read</backlink></links><search><contributor>Abete, Pasquale</contributor><creatorcontrib>Farcet, Anaïs</creatorcontrib><creatorcontrib>de Decker, Laure</creatorcontrib><creatorcontrib>Pauly, Vanessa</creatorcontrib><creatorcontrib>Rousseau, Frédérique</creatorcontrib><creatorcontrib>Bergman, Howard</creatorcontrib><creatorcontrib>Molines, Catherine</creatorcontrib><creatorcontrib>Retornaz, Frédérique</creatorcontrib><title>Frailty Markers and Treatment Decisions in Patients Seen in Oncogeriatric Clinics: Results from the ASRO Pilot Study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Comprehensive Geriatric Assessment (CGA) is the gold standard to help oncologists select the best cancer treatment for their older patients. Some authors have suggested that the concept of frailty could be a more useful approach in this population. We investigated whether frailty markers are associated with treatment recommendations in an oncogeriatric clinic.
This prospective study included 70 years and older patients with solid tumors and referred for an oncogeriatric assessment. The CGA included nine domains: autonomy, comorbidities, medication, cognition, nutrition, mood, neurosensory deficits, falls, and social status. Five frailty markers were assessed (nutrition, physical activity, energy, mobility, and strength). Patients were categorized as Frail (three or more frailty markers), pre-frail (one or two frailty markers), or not-frail (no frailty marker). Treatment recommendations were classified into two categories: standard treatment with and without any changes and supportive/palliative care. Multiple logistic regression models were used to analyze factors associated with treatment recommendations.
217 patients, mean age 83 years (± Standard deviation (SD) 5.3), were included. In the univariate analysis, number of frailty markers, grip strength, physical activity, mobility, nutrition, energy, autonomy, depression, Eastern Cooperative Oncology Group Scale of Performance Status (ECOG-PS), and falls were significantly associated with final treatment recommendations. In the multivariate analysis, the number of frailty markers and basic Activities of Daily Living (ADL) were significantly associated with final treatment recommendations (p<0.001 and p = 0.010, respectively).
Frailty markers are associated with final treatment recommendations in older cancer patients. Longitudinal studies are warranted to better determine their use in a geriatric oncology setting.</description><subject>Activities of daily living</subject><subject>Aged, 80 and over</subject><subject>Ambulatory Care Facilities</subject><subject>Autonomy</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - metabolism</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Care and treatment</subject><subject>Clinical Decision-Making</subject><subject>Cognition</subject><subject>Correlation analysis</subject><subject>Decision making</subject><subject>Drugs</subject><subject>Economics and Finance</subject><subject>Emotions</subject><subject>Energy</subject><subject>Exercise</subject><subject>Female</subject><subject>Frail Elderly</subject><subject>Frailty</subject><subject>Geriatric Assessment</subject><subject>Geriatric nursing</subject><subject>Grip strength</subject><subject>Group dynamics</subject><subject>Human health and pathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Markers</subject><subject>Medical decision making</subject><subject>Medicine and Health Sciences</subject><subject>Mental depression</subject><subject>Methods</subject><subject>Mobility</subject><subject>Mood</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - physiopathology</subject><subject>Neoplasms - therapy</subject><subject>Nutrition</subject><subject>Patients</subject><subject>Physical activity</subject><subject>Physiological aspects</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Psychiatrics and mental health</subject><subject>Psychology</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Santé publique et épidémiologie</subject><subject>Social classes</subject><subject>Social interactions</subject><subject>Social status</subject><subject>Solid tumors</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>BHHNA</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkLsoiX-iJ1wgVQNxiYVdVoHt5bj2K2HGxfbmei_x6bdtE67QL6IdfKc99jv8SmK17AcQ8zgx2s3-F7Y8dr1alxC0jCMnhSHsMFoRFGJn97bHxQvQrguywrXlD4vDhBtYN0QdljEUy-MjRvwXfhfygcg-g5ceSXiSvURfFHSBOP6AEwPLkQ0KRjAXKk-B2a9dAvljYjeSHBiTW9k-AQuVRhswrR3KxCXCkzmlzNwYayLYB6HbvOyeKaFDerV7ntU_Dj9enVyNprOvp2fTKYjyRCNI1JWSLO6QqgkrcSEQNSyukWioZq1Fa4gJbVGpURlA6GGjOgKY91KyoSsaI2Pirdb3bV1ge8MCxwyBhGDVU0Tcb4lOieu-dqblfAb7oTh_wLOL7jw0UireNVqTJuK1YJ1pIGklp1OjcBM5foka33eVRvalepkssoLuye6_6c3S75wN5yw3A6YBI63AssHaWeTKc-x1OUaVSW8yeyHXTHvfg8qRL4yQSprRa_ckO9IG4oobvK53j1AH3diRy1EuqzptUtnlFmUTwghOEmV2dHxI1RanVoZmV6iNim-l3C8l5CYqP7EhRhC4Ofzy_9nZz_32ff32KUSNi6Ds0PMj3UfJFtQeheCV_rOWVjyPEi3bvA8SHw3SCntzf1m3iXdTg7-C2aQFVw</recordid><startdate>20160226</startdate><enddate>20160226</enddate><creator>Farcet, Anaïs</creator><creator>de Decker, Laure</creator><creator>Pauly, Vanessa</creator><creator>Rousseau, Frédérique</creator><creator>Bergman, Howard</creator><creator>Molines, Catherine</creator><creator>Retornaz, Frédérique</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U4</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHHNA</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWI</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>WZK</scope><scope>7X8</scope><scope>1XC</scope><scope>BXJBU</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160226</creationdate><title>Frailty Markers and Treatment Decisions in Patients Seen in Oncogeriatric Clinics: Results from the ASRO Pilot Study</title><author>Farcet, Anaïs ; de Decker, Laure ; Pauly, Vanessa ; Rousseau, Frédérique ; Bergman, Howard ; Molines, Catherine ; Retornaz, Frédérique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c726t-4052f7852204bc34412b78b2a96f7b5351648f20c20911f174f533fbc67ac5683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activities of daily living</topic><topic>Aged, 80 and over</topic><topic>Ambulatory Care Facilities</topic><topic>Autonomy</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - metabolism</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Care and treatment</topic><topic>Clinical Decision-Making</topic><topic>Cognition</topic><topic>Correlation analysis</topic><topic>Decision making</topic><topic>Drugs</topic><topic>Economics and Finance</topic><topic>Emotions</topic><topic>Energy</topic><topic>Exercise</topic><topic>Female</topic><topic>Frail Elderly</topic><topic>Frailty</topic><topic>Geriatric Assessment</topic><topic>Geriatric nursing</topic><topic>Grip strength</topic><topic>Group dynamics</topic><topic>Human health and pathology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Longitudinal studies</topic><topic>Male</topic><topic>Markers</topic><topic>Medical decision making</topic><topic>Medicine and Health Sciences</topic><topic>Mental depression</topic><topic>Methods</topic><topic>Mobility</topic><topic>Mood</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>Neoplasms - 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Some authors have suggested that the concept of frailty could be a more useful approach in this population. We investigated whether frailty markers are associated with treatment recommendations in an oncogeriatric clinic.
This prospective study included 70 years and older patients with solid tumors and referred for an oncogeriatric assessment. The CGA included nine domains: autonomy, comorbidities, medication, cognition, nutrition, mood, neurosensory deficits, falls, and social status. Five frailty markers were assessed (nutrition, physical activity, energy, mobility, and strength). Patients were categorized as Frail (three or more frailty markers), pre-frail (one or two frailty markers), or not-frail (no frailty marker). Treatment recommendations were classified into two categories: standard treatment with and without any changes and supportive/palliative care. Multiple logistic regression models were used to analyze factors associated with treatment recommendations.
217 patients, mean age 83 years (± Standard deviation (SD) 5.3), were included. In the univariate analysis, number of frailty markers, grip strength, physical activity, mobility, nutrition, energy, autonomy, depression, Eastern Cooperative Oncology Group Scale of Performance Status (ECOG-PS), and falls were significantly associated with final treatment recommendations. In the multivariate analysis, the number of frailty markers and basic Activities of Daily Living (ADL) were significantly associated with final treatment recommendations (p<0.001 and p = 0.010, respectively).
Frailty markers are associated with final treatment recommendations in older cancer patients. Longitudinal studies are warranted to better determine their use in a geriatric oncology setting.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26918947</pmid><doi>10.1371/journal.pone.0149732</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1771271586 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Free E-Journal (出版社公開部分のみ）; PubMed Central; Free Full-Text Journals in Chemistry; Sociological Abstracts |
| subjects | Activities of daily living Aged, 80 and over Ambulatory Care Facilities Autonomy Biology and Life Sciences Biomarkers - metabolism Cancer Cancer patients Care and treatment Clinical Decision-Making Cognition Correlation analysis Decision making Drugs Economics and Finance Emotions Energy Exercise Female Frail Elderly Frailty Geriatric Assessment Geriatric nursing Grip strength Group dynamics Human health and pathology Humanities and Social Sciences Humans Life Sciences Longitudinal studies Male Markers Medical decision making Medicine and Health Sciences Mental depression Methods Mobility Mood Mortality Multivariate analysis Neoplasms - metabolism Neoplasms - physiopathology Neoplasms - therapy Nutrition Patients Physical activity Physiological aspects Pilot Projects Prospective Studies Psychiatrics and mental health Psychology Regression analysis Regression models Santé publique et épidémiologie Social classes Social interactions Social status Solid tumors Tumors |
| title | Frailty Markers and Treatment Decisions in Patients Seen in Oncogeriatric Clinics: Results from the ASRO Pilot Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T07%3A40%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Frailty%20Markers%20and%20Treatment%20Decisions%20in%20Patients%20Seen%20in%20Oncogeriatric%20Clinics:%20Results%20from%20the%20ASRO%20Pilot%20Study&rft.jtitle=PloS%20one&rft.au=Farcet,%20Ana%C3%AFs&rft.date=2016-02-26&rft.volume=11&rft.issue=2&rft.spage=e0149732&rft.epage=e0149732&rft.pages=e0149732-e0149732&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0149732&rft_dat=%3Cgale_plos_%3EA444363908%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1771271586&rft_id=info:pmid/26918947&rft_galeid=A444363908&rft_doaj_id=oai_doaj_org_article_5bf369578a7d49148cdf13737ec20946&rfr_iscdi=true |