Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus

The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0150283-e0150283
Hauptverfasser:	Kim, Kwangwoo, Bang, So-Young, Yoo, Dae Hyun, Cho, Soo-Kyung, Choi, Chan-Bum, Sung, Yoon-Kyoung, Kim, Tae-Hwan, Jun, Jae-Bum, Kang, Young Mo, Suh, Chang-Hee, Shim, Seung-Cheol, Lee, Shin-Seok, Lee, Jisoo, Chung, Won Tae, Kim, Seong-Kyu, Choe, Jung-Yoon, Nath, Swapan K, Lee, Hye-Soon, Bae, Sang-Cheol
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino acids Analysis Antigens Arthritis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Asian Continental Ancestry Group - genetics Autoimmune diseases Biology and Life Sciences Case-Control Studies Chronic conditions Disease Disease control Drb1 protein Genes Genes, MHC Class II Genetic aspects Genetic Association Studies Genetic Predisposition to Disease Haplotypes Haplotypes - genetics Histocompatibility antigen HLA HLA antigens HLA-DRB1 Chains - genetics HLA-DRB3 Chains - genetics HLA-DRB4 Chains - genetics HLA-DRB5 Chains - genetics Hospitals Humans Immunology Internal medicine Likelihood ratio Lupus Lupus Erythematosus, Systemic - genetics Lupus Erythematosus, Systemic - immunology Major histocompatibility complex Medicine Medicine and Health Sciences Physiological aspects Polymorphism, Single Nucleotide Regression analysis Republic of Korea Research and Analysis Methods Review boards Rheumatic diseases Rheumatoid arthritis Rheumatology Risk factors Single-nucleotide polymorphism Statistical analysis Systemic lupus erythematosus
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