Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate Cells

To evaluate the anti-inflammatory, anti-oxidant and antifibrotic effects of carvedilol (CARV) in rats with ethanol-induced liver injury. Liver injury was induced by gavage administration of alcohol (7 g/kg) for 28 consecutive days. Eighty Wistar rats were pretreated with oral CARV at 1, 3, or 5 mg/k...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148868-e0148868
Hauptverfasser:	Araújo Júnior, Raimundo Fernandes de, Garcia, Vinícius Barreto, Leitão, Renata Ferreira de Carvalho, Brito, Gerly Anne de Castro, Miguel, Emilio de Castro, Guedes, Paulo Marcos Matta, de Araújo, Aurigena Antunes
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcoholic beverages Animals Antioxidants Apoptosis Aspartate aminotransferase Biology and Life Sciences Biomarkers Calcium Carbazoles - pharmacology Carvedilol Causes of Cell adhesion Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Complications and side effects Confocal microscopy Cyclooxygenase-2 Cytokines Cytokines - metabolism Degeneration Diagnosis Disease Models, Animal Dosage and administration Drug therapy Ethanol Ethanol - adverse effects Exposure Fatty liver Fibrosis Gene expression Gene Expression Regulation - drug effects Glutathione Glutathione peroxidase Glutathione Peroxidase - metabolism Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatology Immunohistochemistry Inflammation Inflammatory response Injuries Intercellular adhesion molecule 1 Interleukin Interleukin 10 Kinases Kupffer Cells - drug effects Kupffer Cells - metabolism Lipids Liver Liver Cirrhosis - drug therapy Liver Cirrhosis - etiology Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Male Malondialdehyde - metabolism Medical research Medicine and Health Sciences Microscopy Morphology mRNA NF-κB protein Oxidative stress Oxidative Stress - drug effects Pathogenesis Peroxidase Peroxidase - metabolism Physical Sciences Physiology Procollagen Propanolamines - pharmacology Proteins Rats Real time RNA, Messenger - genetics Rodents Signal transduction Signaling SOCS-1 protein Studies Superoxide dismutase Superoxide Dismutase - metabolism TRANCE protein Tumor necrosis factor-TNF
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