Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein Expression

The hepatitis B virus (HBV) infection is accompanied by the induction of oxidative stress, especially mediated by HBV X protein (HBx). Oxidative stress has been implicated in a series of pathological states, such as DNA damage, cell survival and apoptosis. However, the host factor by which cells pro...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150961-e0150961
Hauptverfasser:	Ren, Ji-Hua, Chen, Xiang, Zhou, Li, Tao, Na-Na, Zhou, Hong-Zhong, Liu, Bo, Li, Wan-Yu, Huang, Ai-Long, Chen, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Antioxidants Apoptosis Biology and Life Sciences Cell Line Cell survival Collaboration Cysteine Dehydrogenases Deoxyribonucleic acid DNA DNA damage Education Gene Expression HBX protein Health aspects Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - metabolism Hepatitis B virus - physiology Hepatology Hospitals Humans Hydrogen peroxide Infection Infections Infectious diseases Laboratories Liver Liver - cytology Liver - metabolism Liver - virology Mammals Medical diagnosis Medicine and health sciences Mitochondria Mitochondrial DNA Molecular biology Mutagenesis Mutation Oxidative Stress Oxidizing agents Oxygen Pathogenesis Physiological aspects Proteins Public health Reactive oxygen species Reactive Oxygen Species - metabolism Replication Research and Analysis Methods Sirtuin 3 - metabolism Studies Trans-Activators - genetics Virology Virus Replication Viruses
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