Low-Dose Bisphenol-A Impairs Adipogenesis and Generates Dysfunctional 3T3-L1 Adipocytes

Environmental endocrine disruptors (EDCs), including bisphenol-A (BPA), have been recently involved in obesity and diabetes by dysregulating adipose tissue function. Our aim was to examine whether prolonged exposure to low doses of BPA could affect adipogenesis and adipocyte metabolic functions. The...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150762-e0150762
Hauptverfasser:	Ariemma, Fabiana, D'Esposito, Vittoria, Liguoro, Domenico, Oriente, Francesco, Cabaro, Serena, Liotti, Antonietta, Cimmino, Ilaria, Longo, Michele, Beguinot, Francesco, Formisano, Pietro, Valentino, Rossella
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes Adipocytes - drug effects Adipocytes - metabolism Adipocytes - pathology Adipogenesis Adipogenesis - drug effects Adipogenesis - genetics Adipose tissue Animals Benzhydryl Compounds - toxicity Biology and Life Sciences Biomarkers - metabolism Bisphenol A CCAAT/enhancer-binding protein Cell Differentiation - drug effects Cell Differentiation - genetics Cell proliferation Cell Proliferation - drug effects Councils Development and progression Diabetes Diabetes mellitus Differentiation (biology) Endocrine disruptors Endocrinology Eutrophication Exposure Fatty acid-binding protein Fatty acids Gene expression Gene Expression Regulation - drug effects Glucose Glucose - metabolism Health risks Inflammation Inflammation - pathology Inflammation Mediators - metabolism Insulin Insulin - metabolism Interferon Interleukin 6 Leptin Lipid Droplets - drug effects Lipid Droplets - metabolism Lipid metabolism Lipid Metabolism - drug effects Lipids Medicine and Health Sciences Metabolism Mice Obesity Oncology Phenols Phenols - toxicity Physiological aspects Proteins Public health Real-Time Polymerase Chain Reaction Risk factors RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Signaling γ-Interferon
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