Inhibition of Nickel Nanoparticles-Induced Toxicity by Epigallocatechin-3-Gallate in JB6 Cells May Be through Down-Regulation of the MAPK Signaling Pathways

With the rapid development in nanotechnology, nickel nanoparticles (Ni NPs) have emerged in the application of nanomedicine in recent years. However, the potential adverse health effects of Ni NPs are unclear. In this study, we examined the inhibition effects of epigallocatechin-3-gallate (EGCG) on...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150954
Hauptverfasser:	Gu, Yuanliang, Wang, Yafei, Zhou, Qi, Bowman, Linda, Mao, Guochuan, Zou, Baobo, Xu, Jin, Liu, Yu, Liu, Kui, Zhao, Jinshun, Ding, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Animals Apoptosis Apoptosis - drug effects Biology and Life Sciences Catechin - analogs & derivatives Catechin - pharmacology Causes of Cell Count Cell cycle Cell Cycle - drug effects Cell Line Cell number Cell Shape - drug effects Cell Survival - drug effects Cytotoxicity Down-Regulation - drug effects Engineering and Technology Epigallocatechin gallate Epigallocatechin-3-gallate Genetic aspects Health aspects Health risks Inhibition Kinases Liver cancer Luciferases - metabolism Lung cancer MAP kinase MAP Kinase Signaling System - drug effects Medical laboratories Medicine Medicine and Health Sciences Metal Nanoparticles - toxicity Metal Nanoparticles - ultrastructure Mice Mitogen-activated protein kinases Molecular biology Nanoparticles Nanotechnology NF-kappa B - metabolism NF-κB protein Nickel Nickel (Metal) Nickel - toxicity Occupational safety Oxidative Stress - drug effects Oxygen Pathways Phosphatase Physical Sciences Physiological aspects Physiology Polyphenols Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Signal transduction Signaling Studies Tea Toxicity Toxicology Transcription Factor AP-1 - metabolism Transcription factors
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