GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia
Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers...
Gespeichert in:
| Veröffentlicht in: | PloS one 2016-03, Vol.11 (3), p.e0149349-e0149349 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0149349 |
|---|---|
| container_issue | 3 |
| container_start_page | e0149349 |
| container_title | PloS one |
| container_volume | 11 |
| creator | Maetzler, Walter Deleersnijder, Willy Hanssens, Valérie Bernard, Alice Brockmann, Kathrin Marquetand, Justus Wurster, Isabel Rattay, Tim W Roncoroni, Lorenzo Schaeffer, Eva Lerche, Stefanie Apel, Anja Deuschle, Christian Berg, Daniela |
| description | Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas MMP9 degrades, as a proteolytic enzyme, components of the extracellular matrix. In this study, cerebrospinal fluid GDF15 and MMP9 levels of 59 PDND, 17 PDD and 23 DLB patients, as well as of 95 controls were determined, and associated with demographic, clinical and biochemical parameters. Our analysis confirmed the already described association of GDF15 levels with age and gender. Corrected GDF15 levels were significantly higher in PDD than in PDND patients, and intermediate in DLB patients. Within Lewy body disorders, GDF15 levels correlated positively with age at onset of Parkinsonism and dementia, Hoehn & Yahr stage and cerebrospinal fluid t-Tau and p-Tau levels, and negatively with the Mini Mental State Examination. Remarkably, it does not relevantly correlate with disease duration. MMP9 was not relevantly associated with any of these parameters. Cerebrospinal GDF15, but not MMP9, may be a potential marker of and in Lewy body disorders. |
| doi_str_mv | 10.1371/journal.pone.0149349 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1770226164</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_a84ffd74fe2a4aa0ab4bf46cd7400f86</doaj_id><sourcerecordid>1770873668</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-40512462d7fc5e393e330c1a2fce1f1192a8e5748d82a09ab1470795c4dc7fcc3</originalsourceid><addsrcrecordid>eNptUk1vEzEQXSEQ_YB_gMASh3JJ6q-1dy-VICElUiJ6gBuSNfGOi8NmHexsUf49brOtWsTJo_F7b-bZryjeMDpmQrPzdehjB-14GzocUyZrIetnxTGrBR8pTsXzR_VRcZLSmtJSVEq9LI64qnPF5HHx43I6Y-X5cj5hBLqGLJdXNZlgxFUMaevzADJre9-QBd5gm4jvyBXEX75LoTtLZOoTQsI76gL_7Mmn0OzJFDfY7Ty8Kl44aBO-Hs7T4vvs87fJl9Hi6-V88nExsiVXu5GkJeNS8UY7W6KoBQpBLQPuLDLHWM2hwlLLqqk40BpWTGqq69LKxmaKFafFu4Putg3JDA-TDNOacq6YkhkxPyCaAGuzjX4DcW8CeHPXCPHaQNx526KBSjrXaOmQgwSgsJIrJ5XNLUpdpbLWxTCtX22wsdlqhPaJ6NObzv801-HGSK11qVkW-DAIxPC7x7QzG58sti10GPrD3pUWSlUZ-v4f6P_dyQPK5k9LEd3DMoya27Dcs8xtWMwQlkx7-9jIA-k-HeIv5mi7cg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770226164</pqid></control><display><type>article</type><title>GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Maetzler, Walter ; Deleersnijder, Willy ; Hanssens, Valérie ; Bernard, Alice ; Brockmann, Kathrin ; Marquetand, Justus ; Wurster, Isabel ; Rattay, Tim W ; Roncoroni, Lorenzo ; Schaeffer, Eva ; Lerche, Stefanie ; Apel, Anja ; Deuschle, Christian ; Berg, Daniela</creator><creatorcontrib>Maetzler, Walter ; Deleersnijder, Willy ; Hanssens, Valérie ; Bernard, Alice ; Brockmann, Kathrin ; Marquetand, Justus ; Wurster, Isabel ; Rattay, Tim W ; Roncoroni, Lorenzo ; Schaeffer, Eva ; Lerche, Stefanie ; Apel, Anja ; Deuschle, Christian ; Berg, Daniela</creatorcontrib><description>Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas MMP9 degrades, as a proteolytic enzyme, components of the extracellular matrix. In this study, cerebrospinal fluid GDF15 and MMP9 levels of 59 PDND, 17 PDD and 23 DLB patients, as well as of 95 controls were determined, and associated with demographic, clinical and biochemical parameters. Our analysis confirmed the already described association of GDF15 levels with age and gender. Corrected GDF15 levels were significantly higher in PDD than in PDND patients, and intermediate in DLB patients. Within Lewy body disorders, GDF15 levels correlated positively with age at onset of Parkinsonism and dementia, Hoehn & Yahr stage and cerebrospinal fluid t-Tau and p-Tau levels, and negatively with the Mini Mental State Examination. Remarkably, it does not relevantly correlate with disease duration. MMP9 was not relevantly associated with any of these parameters. Cerebrospinal GDF15, but not MMP9, may be a potential marker of and in Lewy body disorders.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149349</identifier><identifier>PMID: 26938614</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Basal ganglia ; Biology and Life Sciences ; Brain research ; Case-Control Studies ; Cell proliferation ; Central nervous system diseases ; Cerebrospinal fluid ; Dementia disorders ; Demographics ; Differentiation (biology) ; Disorders ; Extracellular matrix ; Female ; Gelatinase B ; Gene Expression ; Growth Differentiation Factor 15 - cerebrospinal fluid ; Growth Differentiation Factor 15 - genetics ; Humans ; Kinases ; Lewy bodies ; Lewy Body Disease - cerebrospinal fluid ; Lewy Body Disease - diagnosis ; Lewy Body Disease - genetics ; Lewy Body Disease - pathology ; Macrophage inhibitory cytokine-1 ; Macrophages ; Male ; Matrix metalloproteinase ; Matrix Metalloproteinase 9 - cerebrospinal fluid ; Matrix Metalloproteinase 9 - genetics ; Medicine and Health Sciences ; Metalloproteinase ; Middle Aged ; Movement disorders ; Neurodegeneration ; Neurosciences ; Parkinson Disease - cerebrospinal fluid ; Parkinson Disease - diagnosis ; Parkinson Disease - genetics ; Parkinson Disease - pathology ; Parkinson's disease ; Patients ; Physical Sciences ; Protein Isoforms - cerebrospinal fluid ; Protein Isoforms - genetics ; Proteolysis ; Sex Factors ; Social Sciences ; tau Proteins - cerebrospinal fluid ; tau Proteins - genetics ; Transforming growth factor-a ; Transforming growth factor-b</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0149349-e0149349</ispartof><rights>2016 Maetzler et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Maetzler et al 2016 Maetzler et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-40512462d7fc5e393e330c1a2fce1f1192a8e5748d82a09ab1470795c4dc7fcc3</citedby><cites>FETCH-LOGICAL-c526t-40512462d7fc5e393e330c1a2fce1f1192a8e5748d82a09ab1470795c4dc7fcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777571/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777571/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26938614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maetzler, Walter</creatorcontrib><creatorcontrib>Deleersnijder, Willy</creatorcontrib><creatorcontrib>Hanssens, Valérie</creatorcontrib><creatorcontrib>Bernard, Alice</creatorcontrib><creatorcontrib>Brockmann, Kathrin</creatorcontrib><creatorcontrib>Marquetand, Justus</creatorcontrib><creatorcontrib>Wurster, Isabel</creatorcontrib><creatorcontrib>Rattay, Tim W</creatorcontrib><creatorcontrib>Roncoroni, Lorenzo</creatorcontrib><creatorcontrib>Schaeffer, Eva</creatorcontrib><creatorcontrib>Lerche, Stefanie</creatorcontrib><creatorcontrib>Apel, Anja</creatorcontrib><creatorcontrib>Deuschle, Christian</creatorcontrib><creatorcontrib>Berg, Daniela</creatorcontrib><title>GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas MMP9 degrades, as a proteolytic enzyme, components of the extracellular matrix. In this study, cerebrospinal fluid GDF15 and MMP9 levels of 59 PDND, 17 PDD and 23 DLB patients, as well as of 95 controls were determined, and associated with demographic, clinical and biochemical parameters. Our analysis confirmed the already described association of GDF15 levels with age and gender. Corrected GDF15 levels were significantly higher in PDD than in PDND patients, and intermediate in DLB patients. Within Lewy body disorders, GDF15 levels correlated positively with age at onset of Parkinsonism and dementia, Hoehn & Yahr stage and cerebrospinal fluid t-Tau and p-Tau levels, and negatively with the Mini Mental State Examination. Remarkably, it does not relevantly correlate with disease duration. MMP9 was not relevantly associated with any of these parameters. Cerebrospinal GDF15, but not MMP9, may be a potential marker of and in Lewy body disorders.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basal ganglia</subject><subject>Biology and Life Sciences</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Cell proliferation</subject><subject>Central nervous system diseases</subject><subject>Cerebrospinal fluid</subject><subject>Dementia disorders</subject><subject>Demographics</subject><subject>Differentiation (biology)</subject><subject>Disorders</subject><subject>Extracellular matrix</subject><subject>Female</subject><subject>Gelatinase B</subject><subject>Gene Expression</subject><subject>Growth Differentiation Factor 15 - cerebrospinal fluid</subject><subject>Growth Differentiation Factor 15 - genetics</subject><subject>Humans</subject><subject>Kinases</subject><subject>Lewy bodies</subject><subject>Lewy Body Disease - cerebrospinal fluid</subject><subject>Lewy Body Disease - diagnosis</subject><subject>Lewy Body Disease - genetics</subject><subject>Lewy Body Disease - pathology</subject><subject>Macrophage inhibitory cytokine-1</subject><subject>Macrophages</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 9 - cerebrospinal fluid</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Medicine and Health Sciences</subject><subject>Metalloproteinase</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Neurodegeneration</subject><subject>Neurosciences</subject><subject>Parkinson Disease - cerebrospinal fluid</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Protein Isoforms - cerebrospinal fluid</subject><subject>Protein Isoforms - genetics</subject><subject>Proteolysis</subject><subject>Sex Factors</subject><subject>Social Sciences</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>tau Proteins - genetics</subject><subject>Transforming growth factor-a</subject><subject>Transforming growth factor-b</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1vEzEQXSEQ_YB_gMASh3JJ6q-1dy-VICElUiJ6gBuSNfGOi8NmHexsUf49brOtWsTJo_F7b-bZryjeMDpmQrPzdehjB-14GzocUyZrIetnxTGrBR8pTsXzR_VRcZLSmtJSVEq9LI64qnPF5HHx43I6Y-X5cj5hBLqGLJdXNZlgxFUMaevzADJre9-QBd5gm4jvyBXEX75LoTtLZOoTQsI76gL_7Mmn0OzJFDfY7Ty8Kl44aBO-Hs7T4vvs87fJl9Hi6-V88nExsiVXu5GkJeNS8UY7W6KoBQpBLQPuLDLHWM2hwlLLqqk40BpWTGqq69LKxmaKFafFu4Putg3JDA-TDNOacq6YkhkxPyCaAGuzjX4DcW8CeHPXCPHaQNx526KBSjrXaOmQgwSgsJIrJ5XNLUpdpbLWxTCtX22wsdlqhPaJ6NObzv801-HGSK11qVkW-DAIxPC7x7QzG58sti10GPrD3pUWSlUZ-v4f6P_dyQPK5k9LEd3DMoya27Dcs8xtWMwQlkx7-9jIA-k-HeIv5mi7cg</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>Maetzler, Walter</creator><creator>Deleersnijder, Willy</creator><creator>Hanssens, Valérie</creator><creator>Bernard, Alice</creator><creator>Brockmann, Kathrin</creator><creator>Marquetand, Justus</creator><creator>Wurster, Isabel</creator><creator>Rattay, Tim W</creator><creator>Roncoroni, Lorenzo</creator><creator>Schaeffer, Eva</creator><creator>Lerche, Stefanie</creator><creator>Apel, Anja</creator><creator>Deuschle, Christian</creator><creator>Berg, Daniela</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160303</creationdate><title>GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia</title><author>Maetzler, Walter ; Deleersnijder, Willy ; Hanssens, Valérie ; Bernard, Alice ; Brockmann, Kathrin ; Marquetand, Justus ; Wurster, Isabel ; Rattay, Tim W ; Roncoroni, Lorenzo ; Schaeffer, Eva ; Lerche, Stefanie ; Apel, Anja ; Deuschle, Christian ; Berg, Daniela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-40512462d7fc5e393e330c1a2fce1f1192a8e5748d82a09ab1470795c4dc7fcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basal ganglia</topic><topic>Biology and Life Sciences</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Cell proliferation</topic><topic>Central nervous system diseases</topic><topic>Cerebrospinal fluid</topic><topic>Dementia disorders</topic><topic>Demographics</topic><topic>Differentiation (biology)</topic><topic>Disorders</topic><topic>Extracellular matrix</topic><topic>Female</topic><topic>Gelatinase B</topic><topic>Gene Expression</topic><topic>Growth Differentiation Factor 15 - cerebrospinal fluid</topic><topic>Growth Differentiation Factor 15 - genetics</topic><topic>Humans</topic><topic>Kinases</topic><topic>Lewy bodies</topic><topic>Lewy Body Disease - cerebrospinal fluid</topic><topic>Lewy Body Disease - diagnosis</topic><topic>Lewy Body Disease - genetics</topic><topic>Lewy Body Disease - pathology</topic><topic>Macrophage inhibitory cytokine-1</topic><topic>Macrophages</topic><topic>Male</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 9 - cerebrospinal fluid</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Medicine and Health Sciences</topic><topic>Metalloproteinase</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Neurodegeneration</topic><topic>Neurosciences</topic><topic>Parkinson Disease - cerebrospinal fluid</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Protein Isoforms - cerebrospinal fluid</topic><topic>Protein Isoforms - genetics</topic><topic>Proteolysis</topic><topic>Sex Factors</topic><topic>Social Sciences</topic><topic>tau Proteins - cerebrospinal fluid</topic><topic>tau Proteins - genetics</topic><topic>Transforming growth factor-a</topic><topic>Transforming growth factor-b</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maetzler, Walter</creatorcontrib><creatorcontrib>Deleersnijder, Willy</creatorcontrib><creatorcontrib>Hanssens, Valérie</creatorcontrib><creatorcontrib>Bernard, Alice</creatorcontrib><creatorcontrib>Brockmann, Kathrin</creatorcontrib><creatorcontrib>Marquetand, Justus</creatorcontrib><creatorcontrib>Wurster, Isabel</creatorcontrib><creatorcontrib>Rattay, Tim W</creatorcontrib><creatorcontrib>Roncoroni, Lorenzo</creatorcontrib><creatorcontrib>Schaeffer, Eva</creatorcontrib><creatorcontrib>Lerche, Stefanie</creatorcontrib><creatorcontrib>Apel, Anja</creatorcontrib><creatorcontrib>Deuschle, Christian</creatorcontrib><creatorcontrib>Berg, Daniela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maetzler, Walter</au><au>Deleersnijder, Willy</au><au>Hanssens, Valérie</au><au>Bernard, Alice</au><au>Brockmann, Kathrin</au><au>Marquetand, Justus</au><au>Wurster, Isabel</au><au>Rattay, Tim W</au><au>Roncoroni, Lorenzo</au><au>Schaeffer, Eva</au><au>Lerche, Stefanie</au><au>Apel, Anja</au><au>Deuschle, Christian</au><au>Berg, Daniela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-03</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0149349</spage><epage>e0149349</epage><pages>e0149349-e0149349</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Based on animal and ex-vivo experiments, Growth/Differentiation Factor-15 (GDF15, also called Macrophage Inhibitory Cytokine-1, MIC1), a member of the transforming growth factor-beta family, and Matrix Metalloproteinase-9 (MMP9), a member of the matrix metalloprotease family may be potential markers for Lewy body disorders, i.e. Parkinson's disease with (PDD) and without dementia (PDND) and Lewy body dementia (DLB). GDF15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas MMP9 degrades, as a proteolytic enzyme, components of the extracellular matrix. In this study, cerebrospinal fluid GDF15 and MMP9 levels of 59 PDND, 17 PDD and 23 DLB patients, as well as of 95 controls were determined, and associated with demographic, clinical and biochemical parameters. Our analysis confirmed the already described association of GDF15 levels with age and gender. Corrected GDF15 levels were significantly higher in PDD than in PDND patients, and intermediate in DLB patients. Within Lewy body disorders, GDF15 levels correlated positively with age at onset of Parkinsonism and dementia, Hoehn & Yahr stage and cerebrospinal fluid t-Tau and p-Tau levels, and negatively with the Mini Mental State Examination. Remarkably, it does not relevantly correlate with disease duration. MMP9 was not relevantly associated with any of these parameters. Cerebrospinal GDF15, but not MMP9, may be a potential marker of and in Lewy body disorders.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26938614</pmid><doi>10.1371/journal.pone.0149349</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-03, Vol.11 (3), p.e0149349-e0149349 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1770226164 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Age Factors Aged Aged, 80 and over Basal ganglia Biology and Life Sciences Brain research Case-Control Studies Cell proliferation Central nervous system diseases Cerebrospinal fluid Dementia disorders Demographics Differentiation (biology) Disorders Extracellular matrix Female Gelatinase B Gene Expression Growth Differentiation Factor 15 - cerebrospinal fluid Growth Differentiation Factor 15 - genetics Humans Kinases Lewy bodies Lewy Body Disease - cerebrospinal fluid Lewy Body Disease - diagnosis Lewy Body Disease - genetics Lewy Body Disease - pathology Macrophage inhibitory cytokine-1 Macrophages Male Matrix metalloproteinase Matrix Metalloproteinase 9 - cerebrospinal fluid Matrix Metalloproteinase 9 - genetics Medicine and Health Sciences Metalloproteinase Middle Aged Movement disorders Neurodegeneration Neurosciences Parkinson Disease - cerebrospinal fluid Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Patients Physical Sciences Protein Isoforms - cerebrospinal fluid Protein Isoforms - genetics Proteolysis Sex Factors Social Sciences tau Proteins - cerebrospinal fluid tau Proteins - genetics Transforming growth factor-a Transforming growth factor-b |
| title | GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T00%3A03%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GDF15/MIC1%20and%20MMP9%20Cerebrospinal%20Fluid%20Levels%20in%20Parkinson's%20Disease%20and%20Lewy%20Body%20Dementia&rft.jtitle=PloS%20one&rft.au=Maetzler,%20Walter&rft.date=2016-03-03&rft.volume=11&rft.issue=3&rft.spage=e0149349&rft.epage=e0149349&rft.pages=e0149349-e0149349&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0149349&rft_dat=%3Cproquest_plos_%3E1770873668%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1770226164&rft_id=info:pmid/26938614&rft_doaj_id=oai_doaj_org_article_a84ffd74fe2a4aa0ab4bf46cd7400f86&rfr_iscdi=true |