Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion

Pathophysiological conditions such as fibrosis, inflammation, and tumor progression are associated with modification of the extracellular matrix (ECM). These modifications create ligands that differentially interact with cells to promote responses that drive pathological processes. Within the tumor...

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Veröffentlicht in:	PloS one 2016-03, Vol.11 (3), p.e0150287-e0150287
Hauptverfasser:	Mazur, Anna, Holthoff, Emily, Vadali, Shanthi, Kelly, Thomas, Post, Steven R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Biology and Life Sciences Breast - metabolism Breast - pathology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell activation Cell Adhesion Cells, Cultured Cleavage Collagen Collagen (type I) Collagen Type I - metabolism Cytokines Extracellular matrix Female Fibroblast activation protein Fibroblasts Fibrosis Gelatinases - metabolism Growth factors Humans Integrins - metabolism Interdisciplinary aspects Laboratories Macrophages Macrophages - cytology Macrophages - metabolism Macrophages - pathology Medicine and Health Sciences Membrane Proteins - metabolism Mice, Inbred C57BL Peptidase Proteins Recombinant Proteins - metabolism Research and Analysis Methods Scavenger receptors Scavenger Receptors, Class A - metabolism Serine Endopeptidases - metabolism Stroma Substrates Tumors
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