Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model
To observe dynamic changes in root resorption repair, tooth movement relapse and alveolar bone microstructure following the application of orthodontic force. Forces of 20 g, 50 g or 100 g were delivered to the left maxillary first molars of fifteen 10-week-old rats for 14 days. Each rat was subjecte...
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| description | To observe dynamic changes in root resorption repair, tooth movement relapse and alveolar bone microstructure following the application of orthodontic force.
Forces of 20 g, 50 g or 100 g were delivered to the left maxillary first molars of fifteen 10-week-old rats for 14 days. Each rat was subjected to micro-computed tomography scanning at 0, 3, 7, 10, 14, 28 and 42 days after force removal. The root resorption crater volume, tooth movement relapse and alveolar bone microarchitecture were measured at each time point.
From day 3 to day 14, the root resorption volume decreased significantly in each group. In the 20-g force group, the root resorption volume gradually stabilized after 14 days, whereas in the 50-g and 100-g force groups, it stabilized after 28 days. In all groups, tooth movement relapsed significantly from day 0 to day 14 and then remained stable. From day 3 to day 10, the 20-g group exhibited faster relapse than the 50-g and 100-g groups. In all groups, the structure model index and trabecular separation decreased slowly from day 0 to day 10 and eventually stabilized. Trabecular number increased slowly from day 0 to day 7 and then stabilized.
The initial stage of root resorption repair did not change significantly and was followed by a dramatic repair period before stabilizing. The most serious tooth movement relapse occurred immediately after the appliance was removed, and then the tooth completely returned to the original position. |
| doi_str_mv | 10.1371/journal.pone.0150135 |
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Forces of 20 g, 50 g or 100 g were delivered to the left maxillary first molars of fifteen 10-week-old rats for 14 days. Each rat was subjected to micro-computed tomography scanning at 0, 3, 7, 10, 14, 28 and 42 days after force removal. The root resorption crater volume, tooth movement relapse and alveolar bone microarchitecture were measured at each time point.
From day 3 to day 14, the root resorption volume decreased significantly in each group. In the 20-g force group, the root resorption volume gradually stabilized after 14 days, whereas in the 50-g and 100-g force groups, it stabilized after 28 days. In all groups, tooth movement relapsed significantly from day 0 to day 14 and then remained stable. From day 3 to day 10, the 20-g group exhibited faster relapse than the 50-g and 100-g groups. In all groups, the structure model index and trabecular separation decreased slowly from day 0 to day 10 and eventually stabilized. Trabecular number increased slowly from day 0 to day 7 and then stabilized.
The initial stage of root resorption repair did not change significantly and was followed by a dramatic repair period before stabilizing. The most serious tooth movement relapse occurred immediately after the appliance was removed, and then the tooth completely returned to the original position.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0150135</identifier><identifier>PMID: 26930605</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alveolar bone ; Analysis ; Animals ; Biology and Life Sciences ; Bone and Bones - diagnostic imaging ; CAT scans ; Computation ; Computed tomography ; Computer architecture ; Diagnosis ; Dynamic tests ; Laboratories ; Ligaments ; Male ; Maxilla ; Medical imaging ; Medicine and Health Sciences ; Methods ; Microscopy ; Molar - diagnostic imaging ; Molars ; Oral diseases ; Orthodontics ; Physical properties ; Physical Sciences ; Radiography ; Rats ; Rats, Sprague-Dawley ; Repair ; Research and Analysis Methods ; Rodents ; Root resorption ; Root Resorption - diagnostic imaging ; Science ; Studies ; Teeth ; Tooth diseases ; Tooth Movement Techniques ; Tooth Root - diagnostic imaging ; Tooth roots ; Volumetric analysis</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0150135-e0150135</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Xu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Xu et al 2016 Xu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-563f8e4810a9954665dac790ddaf5f8d145a433a6a0919be4d6b2725199d5c483</citedby><cites>FETCH-LOGICAL-c692t-563f8e4810a9954665dac790ddaf5f8d145a433a6a0919be4d6b2725199d5c483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773112/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773112/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2930,23873,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26930605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Teixeira, Cristina</contributor><creatorcontrib>Xu, Xiaolin</creatorcontrib><creatorcontrib>Zhou, Jianping</creatorcontrib><creatorcontrib>Yang, Fengxue</creatorcontrib><creatorcontrib>Wei, Shicheng</creatorcontrib><creatorcontrib>Dai, Hongwei</creatorcontrib><title>Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To observe dynamic changes in root resorption repair, tooth movement relapse and alveolar bone microstructure following the application of orthodontic force.
Forces of 20 g, 50 g or 100 g were delivered to the left maxillary first molars of fifteen 10-week-old rats for 14 days. Each rat was subjected to micro-computed tomography scanning at 0, 3, 7, 10, 14, 28 and 42 days after force removal. The root resorption crater volume, tooth movement relapse and alveolar bone microarchitecture were measured at each time point.
From day 3 to day 14, the root resorption volume decreased significantly in each group. In the 20-g force group, the root resorption volume gradually stabilized after 14 days, whereas in the 50-g and 100-g force groups, it stabilized after 28 days. In all groups, tooth movement relapsed significantly from day 0 to day 14 and then remained stable. From day 3 to day 10, the 20-g group exhibited faster relapse than the 50-g and 100-g groups. In all groups, the structure model index and trabecular separation decreased slowly from day 0 to day 10 and eventually stabilized. Trabecular number increased slowly from day 0 to day 7 and then stabilized.
The initial stage of root resorption repair did not change significantly and was followed by a dramatic repair period before stabilizing. The most serious tooth movement relapse occurred immediately after the appliance was removed, and then the tooth completely returned to the original position.</description><subject>Alveolar bone</subject><subject>Analysis</subject><subject>Animals</subject><subject>Biology and Life Sciences</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>CAT scans</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Computer architecture</subject><subject>Diagnosis</subject><subject>Dynamic tests</subject><subject>Laboratories</subject><subject>Ligaments</subject><subject>Male</subject><subject>Maxilla</subject><subject>Medical imaging</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Microscopy</subject><subject>Molar - diagnostic imaging</subject><subject>Molars</subject><subject>Oral diseases</subject><subject>Orthodontics</subject><subject>Physical properties</subject><subject>Physical Sciences</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Repair</subject><subject>Research and Analysis Methods</subject><subject>Rodents</subject><subject>Root resorption</subject><subject>Root Resorption - diagnostic imaging</subject><subject>Science</subject><subject>Studies</subject><subject>Teeth</subject><subject>Tooth diseases</subject><subject>Tooth Movement Techniques</subject><subject>Tooth Root - diagnostic imaging</subject><subject>Tooth roots</subject><subject>Volumetric analysis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eKPxIlvkKYxoNKmSmXj1jq1ndaTGwfbmei_x2Hd1KJdIF_Ycp73dc5XUbwmeEpYTT7d-CF04Ka978wUkwoTVj0pjolgdMIpZk_3zkfFixhvMK5Yw_nz4ohywTDH1XGxvY62W6FLq4KfnPlNPySj0ZXf-FWAfr1FyaPzW3ADJIPS2qAv2w42VkXkWzQPae2175JV4NwWzTo9qCxfeJ_QwkQf-mR9l4892IBshwAtIKFLr417WTxrwUXzarefFNdfz6_Ovk8u5t9mZ6cXE8UFTZOKs7YxZUMwCFGVnFcaVC2w1tBWbaNJWUHJGHDAgoilKTVf0ppWRAhdqbJhJ8XbO9_e-Sh3WYuS1Fxw2uCGZWJ2R2gPN7IPdgNhKz1Y-ffCh5WEkGN0RoJoWw4tqVvdlkKZJSiBKeWUKQxM0Oz1effasNwYrUyXArgD08MvnV3Llb-VZV0zQkaDDzuD4H8NJia5sVEZ56Azfhj_u8aU1FWu4Enx7h_08eh21ApyALZrfX5XjabytCzLumGUjVmaPkLlpU2udm6x1ub7A8HHA0FmkvmdVjDEKGc_Fv_Pzn8esu_32LUBl9bRu2FspHgIlndg7twYg2kfkkywHCfkPhtynBC5m5Ase7NfoAfR_UiwPyiRC8s</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Xu, Xiaolin</creator><creator>Zhou, Jianping</creator><creator>Yang, Fengxue</creator><creator>Wei, Shicheng</creator><creator>Dai, Hongwei</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160301</creationdate><title>Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model</title><author>Xu, Xiaolin ; Zhou, Jianping ; Yang, Fengxue ; Wei, Shicheng ; Dai, Hongwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-563f8e4810a9954665dac790ddaf5f8d145a433a6a0919be4d6b2725199d5c483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alveolar bone</topic><topic>Analysis</topic><topic>Animals</topic><topic>Biology and Life Sciences</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>CAT scans</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Computer architecture</topic><topic>Diagnosis</topic><topic>Dynamic tests</topic><topic>Laboratories</topic><topic>Ligaments</topic><topic>Male</topic><topic>Maxilla</topic><topic>Medical imaging</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Microscopy</topic><topic>Molar - diagnostic imaging</topic><topic>Molars</topic><topic>Oral diseases</topic><topic>Orthodontics</topic><topic>Physical properties</topic><topic>Physical Sciences</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Repair</topic><topic>Research and Analysis Methods</topic><topic>Rodents</topic><topic>Root resorption</topic><topic>Root Resorption - diagnostic imaging</topic><topic>Science</topic><topic>Studies</topic><topic>Teeth</topic><topic>Tooth diseases</topic><topic>Tooth Movement Techniques</topic><topic>Tooth Root - diagnostic imaging</topic><topic>Tooth roots</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiaolin</creatorcontrib><creatorcontrib>Zhou, Jianping</creatorcontrib><creatorcontrib>Yang, Fengxue</creatorcontrib><creatorcontrib>Wei, Shicheng</creatorcontrib><creatorcontrib>Dai, Hongwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiaolin</au><au>Zhou, Jianping</au><au>Yang, Fengxue</au><au>Wei, Shicheng</au><au>Dai, Hongwei</au><au>Teixeira, Cristina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0150135</spage><epage>e0150135</epage><pages>e0150135-e0150135</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To observe dynamic changes in root resorption repair, tooth movement relapse and alveolar bone microstructure following the application of orthodontic force.
Forces of 20 g, 50 g or 100 g were delivered to the left maxillary first molars of fifteen 10-week-old rats for 14 days. Each rat was subjected to micro-computed tomography scanning at 0, 3, 7, 10, 14, 28 and 42 days after force removal. The root resorption crater volume, tooth movement relapse and alveolar bone microarchitecture were measured at each time point.
From day 3 to day 14, the root resorption volume decreased significantly in each group. In the 20-g force group, the root resorption volume gradually stabilized after 14 days, whereas in the 50-g and 100-g force groups, it stabilized after 28 days. In all groups, tooth movement relapsed significantly from day 0 to day 14 and then remained stable. From day 3 to day 10, the 20-g group exhibited faster relapse than the 50-g and 100-g groups. In all groups, the structure model index and trabecular separation decreased slowly from day 0 to day 10 and eventually stabilized. Trabecular number increased slowly from day 0 to day 7 and then stabilized.
The initial stage of root resorption repair did not change significantly and was followed by a dramatic repair period before stabilizing. The most serious tooth movement relapse occurred immediately after the appliance was removed, and then the tooth completely returned to the original position.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26930605</pmid><doi>10.1371/journal.pone.0150135</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alveolar bone Analysis Animals Biology and Life Sciences Bone and Bones - diagnostic imaging CAT scans Computation Computed tomography Computer architecture Diagnosis Dynamic tests Laboratories Ligaments Male Maxilla Medical imaging Medicine and Health Sciences Methods Microscopy Molar - diagnostic imaging Molars Oral diseases Orthodontics Physical properties Physical Sciences Radiography Rats Rats, Sprague-Dawley Repair Research and Analysis Methods Rodents Root resorption Root Resorption - diagnostic imaging Science Studies Teeth Tooth diseases Tooth Movement Techniques Tooth Root - diagnostic imaging Tooth roots Volumetric analysis |
| title | Using Micro-Computed Tomography to Evaluate the Dynamics of Orthodontically Induced Root Resorption Repair in a Rat Model |
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