Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
Determination of mitral flow is an important aspect in assessment of cardiac function. Traditionally, mitral flow is measured by Doppler echocardiography which suffers from several challenges, particularly related to the direction and the spatial inhomogeneity of flow. These challenges are especiall...
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| description | Determination of mitral flow is an important aspect in assessment of cardiac function. Traditionally, mitral flow is measured by Doppler echocardiography which suffers from several challenges, particularly related to the direction and the spatial inhomogeneity of flow. These challenges are especially prominent in rodents. The purpose of this study was to establish a cardiovascular magnetic resonance (CMR) protocol for evaluation of three-directional mitral flow in a rodent model of cardiac disease.
Three-directional mitral flow were evaluated by phase contrast CMR (PC-CMR) in rats with aortic banding (AB) (N = 7) and sham-operated controls (N = 7). Peak mitral flow and deceleration rate from PC-CMR was compared to conventional Doppler echocardiography. The accuracy of PC-CMR was investigated by comparison of spatiotemporally integrated mitral flow with left ventricular stroke volume assessed by cine CMR.
PC-CMR portrayed the spatial distribution of mitral flow and flow direction in the atrioventricular plane throughout diastole. Both PC-CMR and echocardiography demonstrated increased peak mitral flow velocity and higher deceleration rate in AB compared to sham. Comparison with cine CMR revealed that PC-CMR measured mitral flow with excellent accuracy. Echocardiography presented significantly lower values of flow compared to PC-CMR.
For the first time, we show that PC-CMR offers accurate evaluation of three-directional mitral blood flow in rodents. The method successfully detects alterations in the mitral flow pattern in response to cardiac disease and provides novel insight into the characteristics of mitral flow. |
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Three-directional mitral flow were evaluated by phase contrast CMR (PC-CMR) in rats with aortic banding (AB) (N = 7) and sham-operated controls (N = 7). Peak mitral flow and deceleration rate from PC-CMR was compared to conventional Doppler echocardiography. The accuracy of PC-CMR was investigated by comparison of spatiotemporally integrated mitral flow with left ventricular stroke volume assessed by cine CMR.
PC-CMR portrayed the spatial distribution of mitral flow and flow direction in the atrioventricular plane throughout diastole. Both PC-CMR and echocardiography demonstrated increased peak mitral flow velocity and higher deceleration rate in AB compared to sham. Comparison with cine CMR revealed that PC-CMR measured mitral flow with excellent accuracy. Echocardiography presented significantly lower values of flow compared to PC-CMR.
For the first time, we show that PC-CMR offers accurate evaluation of three-directional mitral blood flow in rodents. The method successfully detects alterations in the mitral flow pattern in response to cardiac disease and provides novel insight into the characteristics of mitral flow.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0150536</identifier><identifier>PMID: 26930073</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Anesthesia ; Animals ; Aorta ; Aortic Diseases - physiopathology ; Banding ; Biology and Life Sciences ; Blood ; Blood flow ; Blood Flow Velocity ; Cardiomegaly - physiopathology ; Compensation ; Coronary artery disease ; Deceleration ; Diastole ; Doppler echocardiography ; Doppler effect ; Echocardiography ; Echocardiography, Doppler - methods ; Evaluation ; Flow velocity ; Heart ; Heart Conduction System - physiology ; Heart Conduction System - physiopathology ; Heart diseases ; Heart failure ; Heart Failure - physiopathology ; Heart Function Tests - instrumentation ; Heart Function Tests - methods ; Hemodynamics ; Hospitals ; Inhomogeneity ; Magnetic resonance ; Magnetic Resonance Imaging, Cine - methods ; Male ; Medical research ; Medicine and Health Sciences ; Mitral valve ; Mitral Valve - physiology ; Mitral Valve - physiopathology ; NMR ; Nuclear magnetic resonance ; Phase contrast ; Physical Sciences ; Rats ; Rats, Wistar ; Reproducibility of Results ; Research and Analysis Methods ; Resonance ; Rodents ; Spatial distribution ; Stroke ; Stroke volume ; Ventricle</subject><ispartof>PloS one, 2016-03, Vol.11 (3), p.e0150536-e0150536</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Skårdal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2016 Skårdal et al 2016 Skårdal et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c782t-8e5795afbe81c15712eaa7a8f41bfc44972d2b03467f12d8f96c87a303977aac3</citedby><cites>FETCH-LOGICAL-c782t-8e5795afbe81c15712eaa7a8f41bfc44972d2b03467f12d8f96c87a303977aac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773091/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773091/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,26546,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26930073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>del Alamo, Juan Carlos</contributor><creatorcontrib>Skårdal, Kristine</creatorcontrib><creatorcontrib>Espe, Emil K S</creatorcontrib><creatorcontrib>Zhang, Lili</creatorcontrib><creatorcontrib>Aronsen, Jan Magnus</creatorcontrib><creatorcontrib>Sjaastad, Ivar</creatorcontrib><title>Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Determination of mitral flow is an important aspect in assessment of cardiac function. Traditionally, mitral flow is measured by Doppler echocardiography which suffers from several challenges, particularly related to the direction and the spatial inhomogeneity of flow. These challenges are especially prominent in rodents. The purpose of this study was to establish a cardiovascular magnetic resonance (CMR) protocol for evaluation of three-directional mitral flow in a rodent model of cardiac disease.
Three-directional mitral flow were evaluated by phase contrast CMR (PC-CMR) in rats with aortic banding (AB) (N = 7) and sham-operated controls (N = 7). Peak mitral flow and deceleration rate from PC-CMR was compared to conventional Doppler echocardiography. The accuracy of PC-CMR was investigated by comparison of spatiotemporally integrated mitral flow with left ventricular stroke volume assessed by cine CMR.
PC-CMR portrayed the spatial distribution of mitral flow and flow direction in the atrioventricular plane throughout diastole. Both PC-CMR and echocardiography demonstrated increased peak mitral flow velocity and higher deceleration rate in AB compared to sham. Comparison with cine CMR revealed that PC-CMR measured mitral flow with excellent accuracy. Echocardiography presented significantly lower values of flow compared to PC-CMR.
For the first time, we show that PC-CMR offers accurate evaluation of three-directional mitral blood flow in rodents. The method successfully detects alterations in the mitral flow pattern in response to cardiac disease and provides novel insight into the characteristics of mitral flow.</description><subject>Analysis</subject><subject>Anesthesia</subject><subject>Animals</subject><subject>Aorta</subject><subject>Aortic Diseases - physiopathology</subject><subject>Banding</subject><subject>Biology and Life Sciences</subject><subject>Blood</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Cardiomegaly - physiopathology</subject><subject>Compensation</subject><subject>Coronary artery disease</subject><subject>Deceleration</subject><subject>Diastole</subject><subject>Doppler echocardiography</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Echocardiography, Doppler - methods</subject><subject>Evaluation</subject><subject>Flow velocity</subject><subject>Heart</subject><subject>Heart Conduction System - physiology</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Function Tests - instrumentation</subject><subject>Heart Function Tests - methods</subject><subject>Hemodynamics</subject><subject>Hospitals</subject><subject>Inhomogeneity</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging, Cine - methods</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Mitral valve</subject><subject>Mitral Valve - physiology</subject><subject>Mitral Valve - physiopathology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phase contrast</subject><subject>Physical Sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Research and Analysis Methods</subject><subject>Resonance</subject><subject>Rodents</subject><subject>Spatial distribution</subject><subject>Stroke</subject><subject>Stroke volume</subject><subject>Ventricle</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>3HK</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJwyOKvxM4FqVpaWqlVUSlcrVlnsusqGy-2s9B_j0N3Sxf1gHJIPHnmHb9jT5a9pGRCuaQfrt3ge-gmK9fjhNCSlLx6lO3TmrOiYoQ_vve9lz0L4ZokRFXV02yPVTUnRPL9bHW18IjFJ-vRROuSYH60hm6AcZG7Nj-30afgced-5rbP4wLzS4j5CYKP-ewm_7KAgMXU9QkLMZ-Cb6xbQzBDBz4_h3mP0Zr8EkMS7w0-z5600AV8sXkfZN-Oj66mJ8XZxefT6eFZYaRisVBYyrqEdoaKGlpKyhBAgmoFnbVGiFqyhs0IF5VsKWtUW1dGSeCE11ICGH6Qvb7VXXUu6E2zgqayqismKlIn4vSWaBxc65W3S_A32oHVfwLOz3XyaE2HOtVqmpJBbVoQjRBKcdXwCnHWGMVBJa2Pm2rDbImNwbEd3Y7o7p_eLvTcrbWQkpOa_t2u8TZE2-veedCUqJLpkikpEvFuU8K7HwOGqJc2GOw66NENozNJWLIny4S--Qd92P-GmkOyaPvWpZ2ZUVQfCiGk4qwctSYPUOlpcGlNunutTfGdhPc7CYmJ-CvOYQhBn369_H_24vsu-_Yeu0Do4iK4bhgvatgFxbaVLgSP7d0xUKLH0dl2Q4-jozejk9Je3T_Cu6TtrPDfqX0Srw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Skårdal, Kristine</creator><creator>Espe, Emil K S</creator><creator>Zhang, Lili</creator><creator>Aronsen, Jan Magnus</creator><creator>Sjaastad, Ivar</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160301</creationdate><title>Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance</title><author>Skårdal, Kristine ; Espe, Emil K S ; Zhang, Lili ; Aronsen, Jan Magnus ; Sjaastad, Ivar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c782t-8e5795afbe81c15712eaa7a8f41bfc44972d2b03467f12d8f96c87a303977aac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Anesthesia</topic><topic>Animals</topic><topic>Aorta</topic><topic>Aortic Diseases - physiopathology</topic><topic>Banding</topic><topic>Biology and Life Sciences</topic><topic>Blood</topic><topic>Blood flow</topic><topic>Blood Flow Velocity</topic><topic>Cardiomegaly - physiopathology</topic><topic>Compensation</topic><topic>Coronary artery disease</topic><topic>Deceleration</topic><topic>Diastole</topic><topic>Doppler echocardiography</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Echocardiography, Doppler - methods</topic><topic>Evaluation</topic><topic>Flow velocity</topic><topic>Heart</topic><topic>Heart Conduction System - physiology</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart diseases</topic><topic>Heart failure</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Function Tests - instrumentation</topic><topic>Heart Function Tests - methods</topic><topic>Hemodynamics</topic><topic>Hospitals</topic><topic>Inhomogeneity</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging, Cine - 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Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skårdal, Kristine</au><au>Espe, Emil K S</au><au>Zhang, Lili</au><au>Aronsen, Jan Magnus</au><au>Sjaastad, Ivar</au><au>del Alamo, Juan Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>11</volume><issue>3</issue><spage>e0150536</spage><epage>e0150536</epage><pages>e0150536-e0150536</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Determination of mitral flow is an important aspect in assessment of cardiac function. Traditionally, mitral flow is measured by Doppler echocardiography which suffers from several challenges, particularly related to the direction and the spatial inhomogeneity of flow. These challenges are especially prominent in rodents. The purpose of this study was to establish a cardiovascular magnetic resonance (CMR) protocol for evaluation of three-directional mitral flow in a rodent model of cardiac disease.
Three-directional mitral flow were evaluated by phase contrast CMR (PC-CMR) in rats with aortic banding (AB) (N = 7) and sham-operated controls (N = 7). Peak mitral flow and deceleration rate from PC-CMR was compared to conventional Doppler echocardiography. The accuracy of PC-CMR was investigated by comparison of spatiotemporally integrated mitral flow with left ventricular stroke volume assessed by cine CMR.
PC-CMR portrayed the spatial distribution of mitral flow and flow direction in the atrioventricular plane throughout diastole. Both PC-CMR and echocardiography demonstrated increased peak mitral flow velocity and higher deceleration rate in AB compared to sham. Comparison with cine CMR revealed that PC-CMR measured mitral flow with excellent accuracy. Echocardiography presented significantly lower values of flow compared to PC-CMR.
For the first time, we show that PC-CMR offers accurate evaluation of three-directional mitral blood flow in rodents. The method successfully detects alterations in the mitral flow pattern in response to cardiac disease and provides novel insight into the characteristics of mitral flow.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26930073</pmid><doi>10.1371/journal.pone.0150536</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2016-03, Vol.11 (3), p.e0150536-e0150536 |
| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; NORA - Norwegian Open Research Archives; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Anesthesia Animals Aorta Aortic Diseases - physiopathology Banding Biology and Life Sciences Blood Blood flow Blood Flow Velocity Cardiomegaly - physiopathology Compensation Coronary artery disease Deceleration Diastole Doppler echocardiography Doppler effect Echocardiography Echocardiography, Doppler - methods Evaluation Flow velocity Heart Heart Conduction System - physiology Heart Conduction System - physiopathology Heart diseases Heart failure Heart Failure - physiopathology Heart Function Tests - instrumentation Heart Function Tests - methods Hemodynamics Hospitals Inhomogeneity Magnetic resonance Magnetic Resonance Imaging, Cine - methods Male Medical research Medicine and Health Sciences Mitral valve Mitral Valve - physiology Mitral Valve - physiopathology NMR Nuclear magnetic resonance Phase contrast Physical Sciences Rats Rats, Wistar Reproducibility of Results Research and Analysis Methods Resonance Rodents Spatial distribution Stroke Stroke volume Ventricle |
| title | Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T03%3A09%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three-Directional%20Evaluation%20of%20Mitral%20Flow%20in%20the%20Rat%20Heart%20by%20Phase-Contrast%20Cardiovascular%20Magnetic%20Resonance&rft.jtitle=PloS%20one&rft.au=Sk%C3%A5rdal,%20Kristine&rft.date=2016-03-01&rft.volume=11&rft.issue=3&rft.spage=e0150536&rft.epage=e0150536&rft.pages=e0150536-e0150536&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0150536&rft_dat=%3Cgale_plos_%3EA444783255%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1769624609&rft_id=info:pmid/26930073&rft_galeid=A444783255&rft_doaj_id=oai_doaj_org_article_2d2dd52a9cfa4d448838d36eebdc83a8&rfr_iscdi=true |