Comprehensive Expression Profiling and Functional Network Analysis of p53-Regulated MicroRNAs in HepG2 Cells Treated with Doxorubicin

Acting as a sequence-specific transcription factor, p53 tumor suppressor involves in a variety of biological processes after being activated by cellular stresses such as DNA damage. In recent years, microRNAs (miRNAs) have been confirmed to be regulated by p53 in several cancer types. However, it is...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149227-e0149227
Hauptverfasser:	Yang, Yalan, Liu, Wenrong, Ding, Ruofan, Xiong, Lili, Dou, Rongkun, Zhang, Yiming, Guo, Zhiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Apoptosis Binding sites Binding Sites - genetics Bioengineering Biological activity Biology and life sciences Cell culture Cell cycle Cell growth Cellular stress response Chromosomes, Human - genetics Cluster Analysis Computational Biology Deoxyribonucleic acid DNA DNA Damage Doxorubicin Doxorubicin - pharmacology Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Ontology Gene Regulatory Networks - drug effects Gene sequencing Health aspects Hep G2 Cells Hepatitis Hepatocellular carcinoma Humans Influence Life sciences Liver cancer Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Network analysis Nucleotides - genetics p53 Protein Phase transitions Promoter Regions, Genetic - genetics Proteins Research and analysis methods Ribonucleic acid RNA Rodents Sequence Analysis, RNA Transcription factors Transcription Initiation Site Tumor suppressor genes Tumor Suppressor Protein p53 - metabolism
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