Predicting Essential Metabolic Genome Content of Niche-Specific Enterobacterial Human Pathogens during Simulation of Host Environments

Microorganisms have evolved to occupy certain environmental niches, and the metabolic genes essential for growth in these locations are retained in the genomes. Many microorganisms inhabit niches located in the human body, sometimes causing disease, and may retain genes essential for growth in locat...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0149423-e0149423
Hauptverfasser:	Ding, Tong, Case, Kyle A, Omolo, Morrine A, Reiland, Holly A, Metz, Zachary P, Diao, Xinyu, Baumler, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological evolution Biology and Life Sciences Computational biology Computer and Information Sciences Computer applications Computer Simulation E coli Enterobacteriaceae - genetics Enterobacteriaceae - growth & development Environmental conditions Escherichia coli Evolution Food science Genes Genes, Bacterial Genetic aspects Genome, Bacterial Genomes Genomics Genotypes Host-bacteria relationships Host-Pathogen Interactions - genetics Human body Humans Identification and classification Infections Linear programming Macrophages Medicine and Health Sciences Metabolism Metabolites Metabolome - genetics Methods Microorganisms Nutrition Organisms Predictions Salmonella Salmonella - genetics Simulation Strains (organisms) Urinary tract Urogenital system
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