Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis
The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich...
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| Veröffentlicht in: | PloS one 2016-02, Vol.11 (2), p.e0149472-e0149472 |
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| creator | Vilar, José M Rubio, Mónica Spinella, Giuseppe Cuervo, Belén Sopena, Joaquín Cugat, Ramón Garcia-Balletbó, Montserrat Dominguez, Juan M Granados, Maria Tvarijonaviciute, Asta Ceron, José J Carrillo, José M |
| description | The aim of this study was to evaluate the use of serum type II collagen cleavage epitope and serum hyaluronic acid as biomarkers for treatment monitoring in osteoarthritic dogs. For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs. |
| doi_str_mv | 10.1371/journal.pone.0149472 |
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For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149472</identifier><identifier>PMID: 26886592</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Adipose tissue ; Analytical chemistry ; Animals ; Arthritis ; Biocompatibility ; Bioindicators ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biomechanical Phenomena ; Cleavage ; Collagen ; Collagen (type II) ; Collagen Type II - blood ; Development and progression ; Dog diseases ; Dogs ; Epitopes ; Epitopes - blood ; Fluids ; Follow-Up Studies ; Genetic aspects ; Growth factors ; Hip ; Hyaluronic acid ; Hyaluronic Acid - blood ; Identification and classification ; Knee ; Medicine and Health Sciences ; Mesenchyme ; Metabolism ; Monitoring ; Osteoarthritis ; Osteoarthritis, Hip - blood ; Osteoarthritis, Hip - physiopathology ; Osteoarthritis, Hip - therapy ; Osteoarthritis, Hip - veterinary ; Properties ; Stem cell transplantation ; Stem cells ; Studies</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149472-e0149472</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Vilar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.</description><subject>Acids</subject><subject>Adipose tissue</subject><subject>Analytical chemistry</subject><subject>Animals</subject><subject>Arthritis</subject><subject>Biocompatibility</subject><subject>Bioindicators</subject><subject>Biological markers</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomechanical Phenomena</subject><subject>Cleavage</subject><subject>Collagen</subject><subject>Collagen (type II)</subject><subject>Collagen Type II - blood</subject><subject>Development and progression</subject><subject>Dog diseases</subject><subject>Dogs</subject><subject>Epitopes</subject><subject>Epitopes - blood</subject><subject>Fluids</subject><subject>Follow-Up Studies</subject><subject>Genetic aspects</subject><subject>Growth factors</subject><subject>Hip</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - blood</subject><subject>Identification and classification</subject><subject>Knee</subject><subject>Medicine and Health Sciences</subject><subject>Mesenchyme</subject><subject>Metabolism</subject><subject>Monitoring</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Hip - blood</subject><subject>Osteoarthritis, Hip - physiopathology</subject><subject>Osteoarthritis, Hip - therapy</subject><subject>Osteoarthritis, Hip - veterinary</subject><subject>Properties</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Studies</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1Fv0zAQxyMEYmPwDRBYQkLw0GI7sd28IJUyaKWhSazwal0SJ3VJ4mA7g34DPjbumk0N2gPKQ6Lz7_73v3Muip4TPCWxIO-2prct1NPOtGqKSZImgj6ITkka0wmnOH549H0SPXFuizGLZ5w_jk4on804S-lp9OdK2b5BC1PXUKkWrXedQqsVWtQKrkMEnXfamxCDtkAHdrmDurem1Tma57pA4NAHbRqwP5R1qDQWra0C36jWoy8B88bqtkKmRB9N5dAv7TdoqTt06bwyYP3Gaq_d0-hRCbVTz4b3WfTt0_l6sZxcXH5eLeYXk5yn1E9inpUUMlIwUTIcmsaMqkwIBikQzEUKQlAWM5bhWVpAlkBJZ6UqRMoJ43kRn0UvD7pdbZwchugkEWEeOGWUBmJ1IAoDW9lZHVrbSQNa3gSMrWRwrfNaScVpHhyUJSU0mZEiFcBpAYIEL5mI46D1fqjWZ40q8jATC_VIdHzS6o2szLVMBBMs4UHgzSBgzc9eOS8b7XIVbqtVpr_xLbAgnO19v_oHvb-7gaogNKDb0oS6-V5UzpMkZgQnYl92eg8VnkI1Og9_XKlDfJTwdpQQGK9--wp65-Tq6uv_s5ffx-zrI3ajoPYbZ-rea9O6MZgcwNwa56wq74ZMsNwvzO005H5h5LAwIe3F8QXdJd1uSPwXqicQLQ</recordid><startdate>20160217</startdate><enddate>20160217</enddate><creator>Vilar, José M</creator><creator>Rubio, Mónica</creator><creator>Spinella, Giuseppe</creator><creator>Cuervo, Belén</creator><creator>Sopena, Joaquín</creator><creator>Cugat, Ramón</creator><creator>Garcia-Balletbó, Montserrat</creator><creator>Dominguez, Juan M</creator><creator>Granados, Maria</creator><creator>Tvarijonaviciute, Asta</creator><creator>Ceron, José J</creator><creator>Carrillo, José M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160217</creationdate><title>Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis</title><author>Vilar, José M ; Rubio, Mónica ; Spinella, Giuseppe ; Cuervo, Belén ; Sopena, Joaquín ; Cugat, Ramón ; Garcia-Balletbó, Montserrat ; Dominguez, Juan M ; Granados, Maria ; Tvarijonaviciute, Asta ; Ceron, José J ; Carrillo, José M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-36bf2ab1d57f50494052eb775a9a10679a7725355b089dab4af28fed796156cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acids</topic><topic>Adipose tissue</topic><topic>Analytical chemistry</topic><topic>Animals</topic><topic>Arthritis</topic><topic>Biocompatibility</topic><topic>Bioindicators</topic><topic>Biological markers</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - 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For this purpose, a treatment model based on mesenchymal stem cells derived from adipose tissue combined with plasma rich in growth factors was used. This clinical study included 10 dogs with hip osteoarthritis. Both analytes were measured in serum at baseline, just before applying the treatment, and 1, 3, and 6 months after treatment. These results were compared with those obtained from force plate analysis using the same animals during the same study period. Levels of type II collagen cleavage epitope decreased and those of hyaluronic acid increased with clinical improvement objectively verified via force plate analysis, suggesting these two biomarkers could be effective as indicators of clinical development of joint disease in dogs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26886592</pmid><doi>10.1371/journal.pone.0149472</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Adipose tissue Analytical chemistry Animals Arthritis Biocompatibility Bioindicators Biological markers Biology and Life Sciences Biomarkers Biomarkers - blood Biomechanical Phenomena Cleavage Collagen Collagen (type II) Collagen Type II - blood Development and progression Dog diseases Dogs Epitopes Epitopes - blood Fluids Follow-Up Studies Genetic aspects Growth factors Hip Hyaluronic acid Hyaluronic Acid - blood Identification and classification Knee Medicine and Health Sciences Mesenchyme Metabolism Monitoring Osteoarthritis Osteoarthritis, Hip - blood Osteoarthritis, Hip - physiopathology Osteoarthritis, Hip - therapy Osteoarthritis, Hip - veterinary Properties Stem cell transplantation Stem cells Studies |
| title | Serum Collagen Type II Cleavage Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis |
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