Anthocyanins in Strawberry Polyphenolic Extract Enhance the Beneficial Effects of Diets with Fructooligosaccharides in the Rat Cecal Environment
The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the ga...
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| Veröffentlicht in: | PloS one 2016-02, Vol.11 (2), p.e0149081-e0149081 |
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| creator | Fotschki, Bartosz Juśkiewicz, Jerzy Jurgoński, Adam Kołodziejczyk, Krzysztof Milala, Joanna Kosmala, Monika Zduńczyk, Zenon |
| description | The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the gastrointestinal tract. Therefore, a 4-week study of forty-eight male Wistar rats was conducted to investigate the physiological response of the rat cecal environment to diets without and with FOS that contained two different strawberry polyphenolic extracts, specifically EP (polyphenolic profile 60, 35, 5, and 0% ellagitannins, proanthocyanidins, flavonols, anthocyanins, respectively) and EPA (polyphenolic profile: 50, 35, 6, and 9%, respectively). When combined with FOS, both extracts beneficially enhanced the acidification of the cecal digesta (P≤0.05 vs the groups without extracts), but the dietary combination of EPA and FOS elicited the greatest reduction in putrefactive short-chain fatty acid production and the lowest fecal β-glucuronidase activity in the cecum (P≤0.05 vs group EP). Moreover, the addition of dietary FOS elevated the metabolism of the examined strawberry extracts in the cecum and thereby increased the concentrations of the metabolites in the cecal digesta and urine (P≤0.05 vs the group with cellulose). Overall, both strawberry extracts modulated the effects of FOS in the gastrointestinal tract; however, the combination with EPA extract that contained anthocyanins exhibited greater beneficial effects in the lower gut environment than the EP extract. |
| doi_str_mv | 10.1371/journal.pone.0149081 |
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However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the gastrointestinal tract. Therefore, a 4-week study of forty-eight male Wistar rats was conducted to investigate the physiological response of the rat cecal environment to diets without and with FOS that contained two different strawberry polyphenolic extracts, specifically EP (polyphenolic profile 60, 35, 5, and 0% ellagitannins, proanthocyanidins, flavonols, anthocyanins, respectively) and EPA (polyphenolic profile: 50, 35, 6, and 9%, respectively). When combined with FOS, both extracts beneficially enhanced the acidification of the cecal digesta (P≤0.05 vs the groups without extracts), but the dietary combination of EPA and FOS elicited the greatest reduction in putrefactive short-chain fatty acid production and the lowest fecal β-glucuronidase activity in the cecum (P≤0.05 vs group EP). Moreover, the addition of dietary FOS elevated the metabolism of the examined strawberry extracts in the cecum and thereby increased the concentrations of the metabolites in the cecal digesta and urine (P≤0.05 vs the group with cellulose). Overall, both strawberry extracts modulated the effects of FOS in the gastrointestinal tract; however, the combination with EPA extract that contained anthocyanins exhibited greater beneficial effects in the lower gut environment than the EP extract.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149081</identifier><identifier>PMID: 26882456</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject><![CDATA[Acid production ; Acidification ; Animal reproduction ; Animals ; Anthocyanins ; Anthocyanins - isolation & purification ; Anthocyanins - pharmacology ; Bioavailability ; Biology and Life Sciences ; Body Weight - drug effects ; Cecum ; Cecum - drug effects ; Cecum - metabolism ; Cecum - physiology ; Cellulose ; Diet ; Diet - methods ; Dietary fiber ; Digestion - drug effects ; Digestion - physiology ; Digestive enzymes ; Enzymes ; Ethanol ; Fatty acids ; Fatty Acids, Volatile - antagonists & inhibitors ; Fatty Acids, Volatile - biosynthesis ; Fatty Acids, Volatile - metabolism ; Flavonols ; Flavonols - isolation & purification ; Flavonols - pharmacology ; Food science ; Fragaria - chemistry ; Fructooligosaccharides ; Gastrointestinal system ; Gastrointestinal tract ; Glucuronidase - antagonists & inhibitors ; Glucuronidase - biosynthesis ; Glucuronidase - metabolism ; Hydrolyzable Tannins - isolation & purification ; Hydrolyzable Tannins - pharmacology ; Intestinal Absorption - drug effects ; Intestinal Absorption - physiology ; Laboratories ; Male ; Medicine and Health Sciences ; Metabolism ; Metabolites ; Microbiota (Symbiotic organisms) ; Nutrition research ; Oligosaccharides ; Oligosaccharides - isolation & purification ; Oligosaccharides - pharmacology ; Physical Sciences ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - isolation & purification ; Polyphenols - pharmacology ; Prebiotics ; Proanthocyanidins ; Proanthocyanidins - isolation & purification ; Proanthocyanidins - pharmacology ; Rats ; Rats, Wistar ; Urine]]></subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149081-e0149081</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Fotschki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Fotschki et al 2016 Fotschki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a235b36fb70e73ad829d6187ea653381a1e934b9fca0ba3cb95d06c65ec4b9293</citedby><cites>FETCH-LOGICAL-c692t-a235b36fb70e73ad829d6187ea653381a1e934b9fca0ba3cb95d06c65ec4b9293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755607/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755607/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26882456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Lebedeva, Irina V</contributor><creatorcontrib>Fotschki, Bartosz</creatorcontrib><creatorcontrib>Juśkiewicz, Jerzy</creatorcontrib><creatorcontrib>Jurgoński, Adam</creatorcontrib><creatorcontrib>Kołodziejczyk, Krzysztof</creatorcontrib><creatorcontrib>Milala, Joanna</creatorcontrib><creatorcontrib>Kosmala, Monika</creatorcontrib><creatorcontrib>Zduńczyk, Zenon</creatorcontrib><title>Anthocyanins in Strawberry Polyphenolic Extract Enhance the Beneficial Effects of Diets with Fructooligosaccharides in the Rat Cecal Environment</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the gastrointestinal tract. Therefore, a 4-week study of forty-eight male Wistar rats was conducted to investigate the physiological response of the rat cecal environment to diets without and with FOS that contained two different strawberry polyphenolic extracts, specifically EP (polyphenolic profile 60, 35, 5, and 0% ellagitannins, proanthocyanidins, flavonols, anthocyanins, respectively) and EPA (polyphenolic profile: 50, 35, 6, and 9%, respectively). When combined with FOS, both extracts beneficially enhanced the acidification of the cecal digesta (P≤0.05 vs the groups without extracts), but the dietary combination of EPA and FOS elicited the greatest reduction in putrefactive short-chain fatty acid production and the lowest fecal β-glucuronidase activity in the cecum (P≤0.05 vs group EP). Moreover, the addition of dietary FOS elevated the metabolism of the examined strawberry extracts in the cecum and thereby increased the concentrations of the metabolites in the cecal digesta and urine (P≤0.05 vs the group with cellulose). Overall, both strawberry extracts modulated the effects of FOS in the gastrointestinal tract; however, the combination with EPA extract that contained anthocyanins exhibited greater beneficial effects in the lower gut environment than the EP extract.</description><subject>Acid production</subject><subject>Acidification</subject><subject>Animal reproduction</subject><subject>Animals</subject><subject>Anthocyanins</subject><subject>Anthocyanins - isolation & purification</subject><subject>Anthocyanins - pharmacology</subject><subject>Bioavailability</subject><subject>Biology and Life Sciences</subject><subject>Body Weight - drug effects</subject><subject>Cecum</subject><subject>Cecum - drug effects</subject><subject>Cecum - metabolism</subject><subject>Cecum - physiology</subject><subject>Cellulose</subject><subject>Diet</subject><subject>Diet - methods</subject><subject>Dietary fiber</subject><subject>Digestion - drug effects</subject><subject>Digestion - physiology</subject><subject>Digestive enzymes</subject><subject>Enzymes</subject><subject>Ethanol</subject><subject>Fatty acids</subject><subject>Fatty Acids, Volatile - antagonists & inhibitors</subject><subject>Fatty Acids, Volatile - biosynthesis</subject><subject>Fatty Acids, Volatile - metabolism</subject><subject>Flavonols</subject><subject>Flavonols - isolation & purification</subject><subject>Flavonols - pharmacology</subject><subject>Food science</subject><subject>Fragaria - chemistry</subject><subject>Fructooligosaccharides</subject><subject>Gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>Glucuronidase - antagonists & inhibitors</subject><subject>Glucuronidase - biosynthesis</subject><subject>Glucuronidase - metabolism</subject><subject>Hydrolyzable Tannins - isolation & purification</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestinal Absorption - physiology</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Nutrition research</subject><subject>Oligosaccharides</subject><subject>Oligosaccharides - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fotschki, Bartosz</au><au>Juśkiewicz, Jerzy</au><au>Jurgoński, Adam</au><au>Kołodziejczyk, Krzysztof</au><au>Milala, Joanna</au><au>Kosmala, Monika</au><au>Zduńczyk, Zenon</au><au>Lebedeva, Irina V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthocyanins in Strawberry Polyphenolic Extract Enhance the Beneficial Effects of Diets with Fructooligosaccharides in the Rat Cecal Environment</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-16</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0149081</spage><epage>e0149081</epage><pages>e0149081-e0149081</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The administration of fructooligosaccharides (FOS) beneficially modulates gastrointestinal functions and may enhance the metabolism of polyphenols. However, different polyphenolic components in the diet may have different influences on the activities of the digestive enzymes and microbiota in the gastrointestinal tract. Therefore, a 4-week study of forty-eight male Wistar rats was conducted to investigate the physiological response of the rat cecal environment to diets without and with FOS that contained two different strawberry polyphenolic extracts, specifically EP (polyphenolic profile 60, 35, 5, and 0% ellagitannins, proanthocyanidins, flavonols, anthocyanins, respectively) and EPA (polyphenolic profile: 50, 35, 6, and 9%, respectively). When combined with FOS, both extracts beneficially enhanced the acidification of the cecal digesta (P≤0.05 vs the groups without extracts), but the dietary combination of EPA and FOS elicited the greatest reduction in putrefactive short-chain fatty acid production and the lowest fecal β-glucuronidase activity in the cecum (P≤0.05 vs group EP). Moreover, the addition of dietary FOS elevated the metabolism of the examined strawberry extracts in the cecum and thereby increased the concentrations of the metabolites in the cecal digesta and urine (P≤0.05 vs the group with cellulose). Overall, both strawberry extracts modulated the effects of FOS in the gastrointestinal tract; however, the combination with EPA extract that contained anthocyanins exhibited greater beneficial effects in the lower gut environment than the EP extract.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26882456</pmid><doi>10.1371/journal.pone.0149081</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-02, Vol.11 (2), p.e0149081-e0149081 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1765573469 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acid production Acidification Animal reproduction Animals Anthocyanins Anthocyanins - isolation & purification Anthocyanins - pharmacology Bioavailability Biology and Life Sciences Body Weight - drug effects Cecum Cecum - drug effects Cecum - metabolism Cecum - physiology Cellulose Diet Diet - methods Dietary fiber Digestion - drug effects Digestion - physiology Digestive enzymes Enzymes Ethanol Fatty acids Fatty Acids, Volatile - antagonists & inhibitors Fatty Acids, Volatile - biosynthesis Fatty Acids, Volatile - metabolism Flavonols Flavonols - isolation & purification Flavonols - pharmacology Food science Fragaria - chemistry Fructooligosaccharides Gastrointestinal system Gastrointestinal tract Glucuronidase - antagonists & inhibitors Glucuronidase - biosynthesis Glucuronidase - metabolism Hydrolyzable Tannins - isolation & purification Hydrolyzable Tannins - pharmacology Intestinal Absorption - drug effects Intestinal Absorption - physiology Laboratories Male Medicine and Health Sciences Metabolism Metabolites Microbiota (Symbiotic organisms) Nutrition research Oligosaccharides Oligosaccharides - isolation & purification Oligosaccharides - pharmacology Physical Sciences Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Polyphenols - isolation & purification Polyphenols - pharmacology Prebiotics Proanthocyanidins Proanthocyanidins - isolation & purification Proanthocyanidins - pharmacology Rats Rats, Wistar Urine |
| title | Anthocyanins in Strawberry Polyphenolic Extract Enhance the Beneficial Effects of Diets with Fructooligosaccharides in the Rat Cecal Environment |
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