The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty
Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine...
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| creator | Stelmach, Patrick Wedemeyer, Christian Fuest, Lena Kurscheid, Gina Gehrke, Thorsten Klenke, Stefanie Jäger, Marcus Kauther, Max D Bachmann, Hagen S |
| description | Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers. |
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Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0149528</identifier><identifier>PMID: 26881923</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Apoptosis ; Arthritis ; Arthroplasty, Replacement, Hip - adverse effects ; Biology and Life Sciences ; Biomedical materials ; Bone implants ; Cancer ; Deoxyribonucleic acid ; DNA ; Female ; Gene polymorphism ; Genes ; Genetic Association Studies ; Genetic Predisposition to Disease ; Hip ; Hip joint ; Hospitals ; Humans ; Infections ; Joint surgery ; Loosening ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Multivariate Analysis ; Patients ; Physical Sciences ; Polymorphism ; Polymorphism, Single Nucleotide - genetics ; Promoter Regions, Genetic ; Proportional Hazards Models ; Prosthesis Failure ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Research and Analysis Methods ; Risk ; Risk Factors ; Single-nucleotide polymorphism ; Studies ; Surgery ; Surgical implants ; Time Factors ; Total hip arthroplasty</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0149528-e0149528</ispartof><rights>2016 Stelmach et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers.</description><subject>Aged</subject><subject>Apoptosis</subject><subject>Arthritis</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Biology and Life Sciences</subject><subject>Biomedical materials</subject><subject>Bone implants</subject><subject>Cancer</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Hip</subject><subject>Hip joint</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infections</subject><subject>Joint surgery</subject><subject>Loosening</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Promoter Regions, Genetic</subject><subject>Proportional Hazards Models</subject><subject>Prosthesis Failure</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Research and Analysis Methods</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Surgery</subject><subject>Surgical implants</subject><subject>Time Factors</subject><subject>Total hip arthroplasty</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1v0zAYhSMEYmPwDxBY4oabFH_EjnMzqVTAKlViQr23HH-0LkneYLtD5deTrd20Ia5s2c85fo91iuItwTPCavJpB_s46G42wuBmmFQNp_JZcU4aRktBMXv-aH9WvEpphzFnUoiXxRkVUpKGsvPiz3rr0OfFiqKyYXJxOUfXEXrILqJr6A49xHEbUo-WCc1TAhN0dhb9DnmLfoT0E3mISA8WrUPvUIYJcmMOBq0AkhvCsEHg0Rqy7tBVGNE85m2EsdMpH14XL7zukntzWi-K9dcv68VVufr-bbmYr0rDqchlLVopsW0bbJiXnFnruaVtTZ3Fra6ZaaSpnRaaGoo597TiRlpXMW20N55dFO-PtmMHSZ1-LSlSC85ryms-EcsjYUHv1BhDr-NBgQ7q7gDiRuk4heqcqiqnvSaOsKaqmPHSeNoK3WKNrasJnbwuT6_t295Z44YcdffE9OnNELZqAzeqqjnnlZgMPp4MIvzau5RVH5JxXacHB_u7uQUVvGmqCf3wD_r_dNWRMhFSis4_DEOwum3SvUrdNkmdmjTJ3j0O8iC6rw77C-ruyBI</recordid><startdate>20160216</startdate><enddate>20160216</enddate><creator>Stelmach, Patrick</creator><creator>Wedemeyer, Christian</creator><creator>Fuest, Lena</creator><creator>Kurscheid, Gina</creator><creator>Gehrke, Thorsten</creator><creator>Klenke, Stefanie</creator><creator>Jäger, Marcus</creator><creator>Kauther, Max D</creator><creator>Bachmann, Hagen S</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160216</creationdate><title>The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty</title><author>Stelmach, Patrick ; Wedemeyer, Christian ; Fuest, Lena ; Kurscheid, Gina ; Gehrke, Thorsten ; Klenke, Stefanie ; Jäger, Marcus ; Kauther, Max D ; Bachmann, Hagen S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-76b880db90c3f853ddf5d2b72ed0ba73c98c7ea6a2c2055f245c8de43acafcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Apoptosis</topic><topic>Arthritis</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Biology and Life Sciences</topic><topic>Biomedical materials</topic><topic>Bone implants</topic><topic>Cancer</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Hip</topic><topic>Hip joint</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infections</topic><topic>Joint surgery</topic><topic>Loosening</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Promoter Regions, Genetic</topic><topic>Proportional Hazards Models</topic><topic>Prosthesis Failure</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Research and Analysis Methods</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>Surgery</topic><topic>Surgical implants</topic><topic>Time Factors</topic><topic>Total hip arthroplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stelmach, Patrick</creatorcontrib><creatorcontrib>Wedemeyer, Christian</creatorcontrib><creatorcontrib>Fuest, Lena</creatorcontrib><creatorcontrib>Kurscheid, Gina</creatorcontrib><creatorcontrib>Gehrke, Thorsten</creatorcontrib><creatorcontrib>Klenke, Stefanie</creatorcontrib><creatorcontrib>Jäger, Marcus</creatorcontrib><creatorcontrib>Kauther, Max D</creatorcontrib><creatorcontrib>Bachmann, Hagen S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stelmach, Patrick</au><au>Wedemeyer, Christian</au><au>Fuest, Lena</au><au>Kurscheid, Gina</au><au>Gehrke, Thorsten</au><au>Klenke, Stefanie</au><au>Jäger, Marcus</au><au>Kauther, Max D</au><au>Bachmann, Hagen S</au><au>Calafell, Francesc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-16</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0149528</spage><epage>e0149528</epage><pages>e0149528-e0149528</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Aseptic loosening is a major cause of revision surgery of total hip arthroplasty (THA). Only few host factors affecting aseptic loosening have been identified until now, although they are urgently needed to identify and possibly treat those patients at higher risk for aseptic loosening. To determine whether the functional single nucleotide polymorphism (SNP) c.-938C>A (rs2279115), located in the promoter region of the BCL2 gene has an impact on aseptic loosening of THA we genotyped and analyzed 234 patients suffering from aseptic loosening and 231 patients after primary THA. The polymorphism is associated with risk for aseptic loosening with the CC genotype at highest risk for aseptic loosening, Odds Ratio CC vs. AA 1.93, 95%CI 1.15-3.25, p = 0.013. In contrast, low risk AA genotype carriers that still developed aseptic loosening showed a significantly shorter time to aseptic loosening than patients carrying the C allele (p = 0.004). These results indicate that the BCL2 -938C>A polymorphism influences the occurrence and course of aseptic loosening and suggests this polymorphism as an interesting candidate for prospective studies and analyses in THA registers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26881923</pmid><doi>10.1371/journal.pone.0149528</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Apoptosis Arthritis Arthroplasty, Replacement, Hip - adverse effects Biology and Life Sciences Biomedical materials Bone implants Cancer Deoxyribonucleic acid DNA Female Gene polymorphism Genes Genetic Association Studies Genetic Predisposition to Disease Hip Hip joint Hospitals Humans Infections Joint surgery Loosening Male Medical research Medicine and Health Sciences Middle Aged Multivariate Analysis Patients Physical Sciences Polymorphism Polymorphism, Single Nucleotide - genetics Promoter Regions, Genetic Proportional Hazards Models Prosthesis Failure Proto-Oncogene Proteins c-bcl-2 - genetics Research and Analysis Methods Risk Risk Factors Single-nucleotide polymorphism Studies Surgery Surgical implants Time Factors Total hip arthroplasty |
| title | The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty |
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