Light Fractionation Significantly Increases the Efficacy of Photodynamic Therapy Using BF-200 ALA in Normal Mouse Skin

Light fractionation significantly increases the efficacy of 5-aminolevulinic acid (ALA) based photodynamic therapy (PDT) using the nano-emulsion based gel formulation BF-200. PDT using BF-200 ALA has recently been clinically approved and is under investigation in several phase III trials for the tre...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148850
Hauptverfasser:	de Bruijn, Henriëtte S, Brooks, Sander, van der Ploeg-van den Heuvel, Angélique, Ten Hagen, Timo L M, de Haas, Ellen R M, Robinson, Dominic J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aminolevulinic acid Aminolevulinic Acid - analogs & derivatives Aminolevulinic Acid - pharmacokinetics Aminolevulinic Acid - pharmacology Animal models Animals Animals, Outbred Strains Antineoplastic agents Basal cell carcinoma Biology and Life Sciences Cadherins Care and treatment Cervix Clinical trials Dermatology Dose Fractionation, Radiation Drug Evaluation, Preclinical Drug synergism Effectiveness Endothelial Cells - metabolism Female Fluorescence Fluorescence microscopy Formulations Fractionation Gynecology Hairless Illumination Keratosis Light Medicine and Health Sciences Methods Mice Microscopy, Fluorescence Nanoemulsions Observations Oral cancer Oral squamous cell carcinoma Otolaryngology Photobleaching Photochemotherapy Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacokinetics Photosensitizing Agents - pharmacology Physical Sciences Protoporphyrin Protoporphyrin IX Protoporphyrins - pharmacokinetics Research and Analysis Methods Skin Skin - blood supply Skin - drug effects Skin - metabolism Skin cancer Spatial distribution Squamous cell carcinoma Studies Surgery Sus scrofa
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