Risks and Benefits of Nalmefene in the Treatment of Adult Alcohol Dependence: A Systematic Literature Review and Meta-Analysis of Published and Unpublished Double-Blind Randomized Controlled Trials

Nalmefene is a recent option in alcohol dependence treatment. Its approval was controversial. We conducted a systematic review and meta-analysis of the aggregated data (registered as PROSPERO 2014:CRD42014014853) to compare the harm/benefit of nalmefene versus placebo or active comparator in this in...

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Veröffentlicht in:	PLoS medicine 2015-12, Vol.12 (12), p.e1001924-e1001924
Hauptverfasser:	Palpacuer, Clément, Laviolle, Bruno, Boussageon, Rémy, Reymann, Jean Michel, Bellissant, Eric, Naudet, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol use Alcoholism Alcoholism - drug therapy Bias Clinical trials Drug therapy FDA approval Humans Life Sciences Meta-analysis Mortality Naltrexone - adverse effects Naltrexone - analogs & derivatives Naltrexone - therapeutic use Narcotic Antagonists - adverse effects Narcotic Antagonists - therapeutic use Performance evaluation Quality of life Randomized Controlled Trials as Topic Researchers Risk Assessment Studies Treatment Outcome
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