Top2 and Sgs1-Top3 Act Redundantly to Ensure rDNA Replication Termination

Faithful DNA replication with correct termination is essential for genome stability and transmission of genetic information. Here we have investigated the potential roles of Topoisomerase II (Top2) and the RecQ helicase Sgs1 during late stages of replication. We find that cells lacking Top2 and Sgs1...

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Veröffentlicht in:	PLoS genetics 2015-12, Vol.11 (12), p.e1005697-e1005697
Hauptverfasser:	Mundbjerg, Kamilla, Jørgensen, Signe W, Fredsøe, Jacob, Nielsen, Ida, Pedersen, Jakob Madsen, Bentsen, Iben Bach, Lisby, Michael, Bjergbaek, Lotte, Andersen, Anni H
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Chromosomes Chromosomes, Fungal - genetics Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA replication DNA Replication - genetics DNA Topoisomerases, Type I - genetics DNA, Ribosomal - genetics DNA-Binding Proteins - genetics E coli Experiments Genomes Genomic Instability Morphology Observations Physiological aspects Proteins Recombination, Genetic RecQ Helicases - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - genetics Studies Topoisomerases Transcription, Genetic
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