Probing Xist RNA Structure in Cells Using Targeted Structure-Seq

The long non-coding RNA (lncRNA) Xist is a master regulator of X-chromosome inactivation in mammalian cells. Models for how Xist and other lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bas...

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Veröffentlicht in:	PLoS genetics 2015-12, Vol.11 (12), p.e1005668-e1005668
Hauptverfasser:	Fang, Rui, Moss, Walter N, Rutenberg-Schoenberg, Michael, Simon, Matthew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosomes DNA methylation DNA Methylation - genetics Evolution, Molecular Females Gene expression Humans Methods Mice Nucleic Acid Conformation Point Mutation - genetics RNA Folding - genetics RNA sequencing RNA, Long Noncoding - genetics RNA, Ribosomal - genetics Sequence Alignment Sequence Analysis, RNA X Chromosome - genetics X Chromosome Inactivation - genetics
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