Tyro3 Modulates Mertk-Associated Retinal Degeneration

Inherited photoreceptor degenerations (IPDs) are the most genetically heterogeneous of Mendelian diseases. Many IPDs exhibit substantial phenotypic variability, but the basis is usually unknown. Mutations in MERTK cause recessive IPD phenotypes associated with the RP38 locus. We have identified a mu...

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Veröffentlicht in:	PLoS genetics 2015-12, Vol.11 (12), p.e1005723-e1005723
Hauptverfasser:	Vollrath, Douglas, Yasumura, Douglas, Benchorin, Gillie, Matthes, Michael T, Feng, Wei, Nguyen, Natalie M, Sedano, Cecilia D, Calton, Melissa A, LaVail, Matthew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals c-Mer Tyrosine Kinase Disease Disease Models, Animal Gene expression Genetic aspects Genetic variation Humans Localization Mice Mice, Knockout Mutation Observations Phagocytosis Phenotype Photoreceptor Cells - metabolism Photoreceptor Cells - pathology Photoreceptors Proteins Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - genetics Retina Retina - metabolism Retina - pathology Retinal degeneration Retinal Degeneration - genetics Retinal Degeneration - pathology Retinal Pigment Epithelium - pathology
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