A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair

The tripeptide glutathione is the most abundant cellular antioxidant with high medical relevance, and it is also required as a co-factor for various enzymes involved in the detoxification of reactive oxygen species and toxic compounds. However, its cell-type specific functions and its interaction wi...

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Veröffentlicht in:	PLoS genetics 2016-01, Vol.12 (1), p.e1005800
Hauptverfasser:	Telorack, Michèle, Meyer, Michael, Ingold, Irina, Conrad, Marcus, Bloch, Wilhelm, Werner, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antioxidants Antioxidants - metabolism Apoptosis Apoptosis - genetics Biology and Life Sciences Biosynthesis Cancer Care and treatment Cell Survival Defense Diabetes DNA Damage - genetics Dyes Enzymes Experiments Flow cytometry Gene expression Genetic aspects Glutamate-Cysteine Ligase - deficiency Glutamate-Cysteine Ligase - genetics Glutamate-Cysteine Ligase - metabolism Glutathione Glutathione - biosynthesis Glutathione - metabolism Health aspects Immunoglobulins Keratinocytes Keratinocytes - metabolism Keratinocytes - pathology Medicine and Health Sciences Mice Molecular weight NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Observations Oxidative Stress Reactive Oxygen Species - metabolism Research and Analysis Methods Rodents Skin - metabolism Skin - pathology Thioredoxin Thioredoxins - genetics Thioredoxins - metabolism Wound healing Wound Healing - genetics Wounds and injuries
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