Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d'Ivoire, a 5-year cluster-randomized trial...
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| creator | Assaré, Rufin K Tian-Bi, Yves-Nathan T Yao, Patrick K N'Guessan, Nicaise A Ouattara, Mamadou Yapi, Ahoua Coulibaly, Jean T Meïté, Aboulaye Hürlimann, Eveline Knopp, Stefanie Utzinger, Jürg N'Goran, Eliézer K |
| description | The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis mansoni. We report Schistosoma mansoni infection levels in children one year after the initial school-based treatment (SBT) with praziquantel and compare with baseline results to determine the effect of the intervention.
The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up.
The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment, the overall prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5-20.8%) to 12.8% (95% CI: 11.9-13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children slightly increased from 92.2 EPG (95% CI: 79.2-105.3 EPG) to 109.3 EPG (95% CI: 82.7-135.9 EPG). In two of the 50 schools, the prevalence increased significantly, despite a DOT coverage of >75%.
One year after the initial SBT, the S. mansoni prevalence had decreased. Despite this positive trend, an increase was observed in some schools. Moreover, the infection intensity among S. mansoni-infected children was slightly higher at the 1-year follow-up compared to the baseline situation. Our results emphasize the heterogeneity of transmission dynamics and provide a benchmark for the future yearly follow-up surveys of this multi-year SCORE intervention study. |
| doi_str_mv | 10.1371/journal.pntd.0004329 |
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The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up.
The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment, the overall prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5-20.8%) to 12.8% (95% CI: 11.9-13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children slightly increased from 92.2 EPG (95% CI: 79.2-105.3 EPG) to 109.3 EPG (95% CI: 82.7-135.9 EPG). In two of the 50 schools, the prevalence increased significantly, despite a DOT coverage of >75%.
One year after the initial SBT, the S. mansoni prevalence had decreased. Despite this positive trend, an increase was observed in some schools. Moreover, the infection intensity among S. mansoni-infected children was slightly higher at the 1-year follow-up compared to the baseline situation. Our results emphasize the heterogeneity of transmission dynamics and provide a benchmark for the future yearly follow-up surveys of this multi-year SCORE intervention study.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0004329</identifier><identifier>PMID: 26789749</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Animals ; Anthelmintics - administration & dosage ; Chemotherapy ; Child ; Child, Preschool ; Confidence intervals ; Consortia ; Cote d'Ivoire - epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Infection control ; Infections ; Laboratories ; Male ; Patient outcomes ; Praziquantel ; Praziquantel - administration & dosage ; Prevalence ; Prevention ; Schistosoma mansoni ; Schistosoma mansoni - drug effects ; Schistosoma mansoni - physiology ; Schistosomiasis ; Schistosomiasis mansoni - drug therapy ; Schistosomiasis mansoni - epidemiology ; Schistosomiasis mansoni - parasitology ; Schools ; Schools - statistics & numerical data ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2016-01, Vol.10 (1), p.e0004329-e0004329</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Assaré et al 2016 Assaré et al</rights><rights>2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Assaré RK, Tian-Bi Y-NT, Yao PK, N'Guessan NA, Ouattara M, Yapi A, et al. (2016) Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration. PLoS Negl Trop Dis 10(1): e0004329. doi:10.1371/journal.pntd.0004329</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c765t-de285b4cecc541ba0782c3456a5a89c57241c922de60a8a68584b8051f6c66d23</citedby><cites>FETCH-LOGICAL-c765t-de285b4cecc541ba0782c3456a5a89c57241c922de60a8a68584b8051f6c66d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720284/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720284/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26789749$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bethony, Jeffrey Michael</contributor><creatorcontrib>Assaré, Rufin K</creatorcontrib><creatorcontrib>Tian-Bi, Yves-Nathan T</creatorcontrib><creatorcontrib>Yao, Patrick K</creatorcontrib><creatorcontrib>N'Guessan, Nicaise A</creatorcontrib><creatorcontrib>Ouattara, Mamadou</creatorcontrib><creatorcontrib>Yapi, Ahoua</creatorcontrib><creatorcontrib>Coulibaly, Jean T</creatorcontrib><creatorcontrib>Meïté, Aboulaye</creatorcontrib><creatorcontrib>Hürlimann, Eveline</creatorcontrib><creatorcontrib>Knopp, Stefanie</creatorcontrib><creatorcontrib>Utzinger, Jürg</creatorcontrib><creatorcontrib>N'Goran, Eliézer K</creatorcontrib><title>Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis mansoni. We report Schistosoma mansoni infection levels in children one year after the initial school-based treatment (SBT) with praziquantel and compare with baseline results to determine the effect of the intervention.
The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up.
The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment, the overall prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5-20.8%) to 12.8% (95% CI: 11.9-13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children slightly increased from 92.2 EPG (95% CI: 79.2-105.3 EPG) to 109.3 EPG (95% CI: 82.7-135.9 EPG). In two of the 50 schools, the prevalence increased significantly, despite a DOT coverage of >75%.
One year after the initial SBT, the S. mansoni prevalence had decreased. Despite this positive trend, an increase was observed in some schools. Moreover, the infection intensity among S. mansoni-infected children was slightly higher at the 1-year follow-up compared to the baseline situation. Our results emphasize the heterogeneity of transmission dynamics and provide a benchmark for the future yearly follow-up surveys of this multi-year SCORE intervention study.</description><subject>Adolescent</subject><subject>Animals</subject><subject>Anthelmintics - administration & dosage</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Confidence intervals</subject><subject>Consortia</subject><subject>Cote d'Ivoire - epidemiology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Infection control</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Patient outcomes</subject><subject>Praziquantel</subject><subject>Praziquantel - administration & dosage</subject><subject>Prevalence</subject><subject>Prevention</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - drug effects</subject><subject>Schistosoma mansoni - physiology</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis mansoni - drug therapy</subject><subject>Schistosomiasis mansoni - epidemiology</subject><subject>Schistosomiasis mansoni - parasitology</subject><subject>Schools</subject><subject>Schools - statistics & numerical data</subject><subject>Tropical diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNktFqFDEUhgdRbK2-gWhAUC_cNckkk4wXQlmqLlRWuop4Fc5mMrtZZpI2yRTqi_givoEvZra7LV3wQnIxIfP9_0n-c4riKcFjUgrydu2H4KAbn7vUjDHGrKT1veKQ1CUfUVHy-3f2B8WjGNcY85pL8rA4oJWQtWD1YfFrPsQE1lm3RBPvUvAd8i2a65WNyUffW4g2os_goncWWYe-m5hMcGjy53cyqHk1vfQ2mHfozMShSxG1wfcI0HwyOztB8zQ0V2_QzBn0w0BA0GYtmjqbLHToS4Cf9mIAl0yHjps-XyOmAMl697h40EIXzZPd96j49uHk6-TT6HT2cTo5Ph1pUfE0agyVfMG00ZozsgAsJNUl4xVwkLXmgjKia0obU2GQUEku2UJiTtpKV1VDy6Pi-db3vPNR7TKNioiKlZyVRGRiuiUaD2t1HmwP4Up5sOr6wIelgpCs7owCMFjWkreMm1y3XZiSsLYUVAqNS6iz1_tdtWHRm0abHDh0e6b7f5xdqaW_VExQTCXLBq93BsFfDLkTqrdRm64DZ_xwfW9eMyop_x8US0lKLDP6YosuIb_Cutbn4nqDq-OcJRWcY5yp8T-ovBrTW-2daW0-3xO8vCNYGejSKvpu2PQ37oNsC-rgYwymvU2EYLUZ9pvGqM2wq92wZ9mzu2neim6mu_wLFRb9kg</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Assaré, Rufin K</creator><creator>Tian-Bi, Yves-Nathan T</creator><creator>Yao, Patrick K</creator><creator>N'Guessan, Nicaise A</creator><creator>Ouattara, Mamadou</creator><creator>Yapi, Ahoua</creator><creator>Coulibaly, Jean T</creator><creator>Meïté, Aboulaye</creator><creator>Hürlimann, Eveline</creator><creator>Knopp, Stefanie</creator><creator>Utzinger, Jürg</creator><creator>N'Goran, Eliézer K</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160101</creationdate><title>Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration</title><author>Assaré, Rufin K ; Tian-Bi, Yves-Nathan T ; Yao, Patrick K ; N'Guessan, Nicaise A ; Ouattara, Mamadou ; Yapi, Ahoua ; Coulibaly, Jean T ; Meïté, Aboulaye ; Hürlimann, Eveline ; Knopp, Stefanie ; Utzinger, Jürg ; N'Goran, Eliézer K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c765t-de285b4cecc541ba0782c3456a5a89c57241c922de60a8a68584b8051f6c66d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Animals</topic><topic>Anthelmintics - administration & dosage</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Confidence intervals</topic><topic>Consortia</topic><topic>Cote d'Ivoire - epidemiology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Infection control</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Male</topic><topic>Patient outcomes</topic><topic>Praziquantel</topic><topic>Praziquantel - administration & dosage</topic><topic>Prevalence</topic><topic>Prevention</topic><topic>Schistosoma mansoni</topic><topic>Schistosoma mansoni - drug effects</topic><topic>Schistosoma mansoni - physiology</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis mansoni - drug therapy</topic><topic>Schistosomiasis mansoni - epidemiology</topic><topic>Schistosomiasis mansoni - parasitology</topic><topic>Schools</topic><topic>Schools - statistics & numerical data</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Assaré, Rufin K</creatorcontrib><creatorcontrib>Tian-Bi, Yves-Nathan T</creatorcontrib><creatorcontrib>Yao, Patrick K</creatorcontrib><creatorcontrib>N'Guessan, Nicaise A</creatorcontrib><creatorcontrib>Ouattara, Mamadou</creatorcontrib><creatorcontrib>Yapi, Ahoua</creatorcontrib><creatorcontrib>Coulibaly, Jean T</creatorcontrib><creatorcontrib>Meïté, Aboulaye</creatorcontrib><creatorcontrib>Hürlimann, Eveline</creatorcontrib><creatorcontrib>Knopp, Stefanie</creatorcontrib><creatorcontrib>Utzinger, Jürg</creatorcontrib><creatorcontrib>N'Goran, Eliézer K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Assaré, Rufin K</au><au>Tian-Bi, Yves-Nathan T</au><au>Yao, Patrick K</au><au>N'Guessan, Nicaise A</au><au>Ouattara, Mamadou</au><au>Yapi, Ahoua</au><au>Coulibaly, Jean T</au><au>Meïté, Aboulaye</au><au>Hürlimann, Eveline</au><au>Knopp, Stefanie</au><au>Utzinger, Jürg</au><au>N'Goran, Eliézer K</au><au>Bethony, Jeffrey Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>10</volume><issue>1</issue><spage>e0004329</spage><epage>e0004329</epage><pages>e0004329-e0004329</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d'Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis mansoni. We report Schistosoma mansoni infection levels in children one year after the initial school-based treatment (SBT) with praziquantel and compare with baseline results to determine the effect of the intervention.
The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up.
The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5-24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment, the overall prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5-20.8%) to 12.8% (95% CI: 11.9-13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children slightly increased from 92.2 EPG (95% CI: 79.2-105.3 EPG) to 109.3 EPG (95% CI: 82.7-135.9 EPG). In two of the 50 schools, the prevalence increased significantly, despite a DOT coverage of >75%.
One year after the initial SBT, the S. mansoni prevalence had decreased. Despite this positive trend, an increase was observed in some schools. Moreover, the infection intensity among S. mansoni-infected children was slightly higher at the 1-year follow-up compared to the baseline situation. Our results emphasize the heterogeneity of transmission dynamics and provide a benchmark for the future yearly follow-up surveys of this multi-year SCORE intervention study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26789749</pmid><doi>10.1371/journal.pntd.0004329</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2016-01, Vol.10 (1), p.e0004329-e0004329 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1764354317 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; PubMed Central |
| subjects | Adolescent Animals Anthelmintics - administration & dosage Chemotherapy Child Child, Preschool Confidence intervals Consortia Cote d'Ivoire - epidemiology Cross-Sectional Studies Female Humans Infection control Infections Laboratories Male Patient outcomes Praziquantel Praziquantel - administration & dosage Prevalence Prevention Schistosoma mansoni Schistosoma mansoni - drug effects Schistosoma mansoni - physiology Schistosomiasis Schistosomiasis mansoni - drug therapy Schistosomiasis mansoni - epidemiology Schistosomiasis mansoni - parasitology Schools Schools - statistics & numerical data Tropical diseases |
| title | Sustaining Control of Schistosomiasis Mansoni in Western Côte d'Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T20%3A24%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sustaining%20Control%20of%20Schistosomiasis%20Mansoni%20in%20Western%20C%C3%B4te%20d'Ivoire:%20Results%20from%20a%20SCORE%20Study,%20One%20Year%20after%20Initial%20Praziquantel%20Administration&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Assar%C3%A9,%20Rufin%20K&rft.date=2016-01-01&rft.volume=10&rft.issue=1&rft.spage=e0004329&rft.epage=e0004329&rft.pages=e0004329-e0004329&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0004329&rft_dat=%3Cgale_plos_%3EA456275500%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1760881308&rft_id=info:pmid/26789749&rft_galeid=A456275500&rft_doaj_id=oai_doaj_org_article_aae08985f45e41cfbe314f37287c03a9&rfr_iscdi=true |