A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into a novel technology platform (HexaBody technology)...

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Veröffentlicht in:	PLoS biology 2016-01, Vol.14 (1), p.e1002344-e1002344
Hauptverfasser:	de Jong, Rob N, Beurskens, Frank J, Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D, Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J, Oostindie, Simone C, Wang, Guanbo, Heck, Albert J R, Schuurman, Janine, Parren, Paul W H I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody-Dependent Cell Cytotoxicity Antigens Binding sites Cell Line, Tumor Cell surface antigens Complement Activation Cytotoxicity Defense mechanisms Experiments Female Genetic aspects Health aspects Humans Immunoglobulin G Immunoglobulin G - genetics Immunoglobulin G - metabolism Immunoglobulins Immunotherapy Immunotherapy - methods Methods Mice, SCID Molecular weight Mutation Neoplasm Transplantation Pharmaceutical research Polymerization Viral antibodies
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