TLR4 and TLR7/8 Adjuvant Combinations Generate Different Vaccine Antigen-Specific Immune Outcomes in Minipigs when Administered via the ID or IN Routes

The induction of high levels of systemic and mucosal humoral immunity is a key goal for many prophylactic vaccines. However, adjuvant strategies developed in mice have often performed poorly in the clinic. Due to their closer similarity to humans, minipigs may provide a more accurate picture of adju...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148984-e0148984
Hauptverfasser:	McKay, Paul F, King, Deborah F L, Mann, Jamie F S, Barinaga, Guillermo, Carter, Darrick, Shattock, Robin J
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - administration & dosage 1,2-Dipalmitoylphosphatidylcholine - pharmacology Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Animal models Animals Antibody Affinity Antibody Specificity Antigens Antigens - administration & dosage Antigens - immunology Biology and Life Sciences Dose-Response Relationship, Immunologic Drug Combinations env Gene Products, Human Immunodeficiency Virus - administration & dosage env Gene Products, Human Immunodeficiency Virus - immunology Female Gene expression Genetic aspects Glycoproteins HIV HIV Antibodies - biosynthesis HIV Antibodies - blood HIV Antibodies - immunology Human immunodeficiency virus Humoral immunity Imidazoles - administration & dosage Imidazoles - antagonists & inhibitors Immune response Immune response (humoral) Immune system Immunity Immunity, Innate Immunity, Mucosal - drug effects Immunization, Secondary Immunoglobulin G Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G - immunology Immunology Infections Infectious diseases Injections, Intradermal Inoculation Ligands Lipid A - administration & dosage Lipid A - analogs & derivatives Lipid A - pharmacology Medical research Medicine Medicine and Health Sciences Models, Animal Mucosa Mucosal immunity Nasal Mucosa - immunology Neutralization Tests Organ Specificity Pathways Physiological aspects Priming Proteins Rodents Signal transduction Signaling Swine Swine, Miniature TLR4 protein TLR7 protein Toll-Like Receptor 4 - administration & dosage Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - immunology Toll-Like Receptor 7 - administration & dosage Toll-Like Receptor 7 - agonists Toll-Like Receptor 7 - immunology Toll-Like Receptor 8 - administration & dosage Toll-Like Receptor 8 - agonists Toll-Like Receptor 8 - immunology Toll-like receptors Vaccination - methods Vaccines Vagina Vagina - immunology
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