Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension

Serotonergic anorexigens are the primary pharmacologic risk factor associated with pulmonary arterial hypertension (PAH), and the resulting PAH is clinically indistinguishable from the heritable form of disease, associated with BMPR2 mutations. Both BMPR2 mutation and agonists to the serotonin recep...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148657-e0148657
Hauptverfasser:	West, James D, Carrier, Erica J, Bloodworth, Nathaniel C, Schroer, Alison K, Chen, Peter, Ryzhova, Larisa M, Gladson, Santhi, Shay, Sheila, Hutcheson, Joshua D, Merryman, W David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Activation Animal care Animals Antagonists Atomic force microscopy Biology and Life Sciences Biomedical engineering Blood vessels Bone morphogenetic protein receptor type II Bone Morphogenetic Protein Receptors, Type II - deficiency Bone Morphogenetic Protein Receptors, Type II - genetics Cell Movement - drug effects Contraction Critical care Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeleton Disease Engineering Gene expression Gene Expression Profiling Gene Expression Regulation Genetic aspects Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertension, Pulmonary - prevention & control Indoles - pharmacology Inflammation Inhibition Kinases Lung - drug effects Lung - metabolism Lung - pathology Lungs Medicine Medicine and Health Sciences Mice Mice, Transgenic Microscopy Muscle contraction Muscle Contraction - drug effects Muscle Proteins - genetics Muscle Proteins - metabolism Mutation Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Oligonucleotide Array Sequence Analysis Pharmacology Phosphorylation Physiological aspects Prevention Principal components analysis Protein Transport Protein-tyrosine kinase Pulmonary hypertension Receptor, Serotonin, 5-HT2B - genetics Receptor, Serotonin, 5-HT2B - metabolism Recruitment Research and Analysis Methods Risk factors Rodents Serotonin Serotonin Antagonists - pharmacology Signal Transduction Smooth muscle src-Family Kinases - antagonists & inhibitors src-Family Kinases - genetics src-Family Kinases - metabolism Stiffness Tyrosine Urea - analogs & derivatives Urea - pharmacology Vascular Stiffness - drug effects
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