Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea
In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive prolife...
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| creator | Geng, Ruishuang Noda, Teppei Mulvaney, Joanna F Lin, Vincent Y W Edge, Albert S B Dabdoub, Alain |
| description | In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points.
We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity.
A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study. |
| doi_str_mv | 10.1371/journal.pone.0148339 |
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We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity.
A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0148339</identifier><identifier>PMID: 26859490</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Biology ; Biology and Life Sciences ; Cell cycle ; Cell fate ; Cell proliferation ; Cellular signal transduction ; Cochlea ; Cochlea - cytology ; Cochlea - embryology ; Cochlea - growth & development ; Cochlea - metabolism ; Cochlear Duct - cytology ; Cochlear Duct - embryology ; Cochlear Duct - growth & development ; Cochlear Duct - metabolism ; Deoxyribonucleic acid ; DNA ; Embryos ; Epithelium ; Extracellular Space - metabolism ; Gene expression ; Gene Expression Regulation, Developmental ; Genes ; Genetic engineering ; Hair ; Heparan sulfate ; Homeostasis ; Inner ear ; Intracellular signalling ; Intracellular Space - metabolism ; Kinases ; Laboratories ; Ligands ; Mammals ; Maturation ; Medicine and Health Sciences ; Mesenchyme ; Mice ; Neonates ; Otolaryngology ; Otology ; Polarity ; Proteins ; Regeneration ; Regulators ; Sensory epithelium ; Signal transduction ; Spatio-Temporal Analysis ; Stria vascularis ; Wnt protein ; Wnt proteins ; Wnt Proteins - antagonists & inhibitors ; Wnt Signaling Pathway - genetics</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0148339-e0148339</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Geng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Geng et al 2016 Geng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c5c085b277568732670bdd64ebc476b00f9a0fbf8e07c03eba344b234bed828a3</citedby><cites>FETCH-LOGICAL-c692t-c5c085b277568732670bdd64ebc476b00f9a0fbf8e07c03eba344b234bed828a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747503/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747503/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26859490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geng, Ruishuang</creatorcontrib><creatorcontrib>Noda, Teppei</creatorcontrib><creatorcontrib>Mulvaney, Joanna F</creatorcontrib><creatorcontrib>Lin, Vincent Y W</creatorcontrib><creatorcontrib>Edge, Albert S B</creatorcontrib><creatorcontrib>Dabdoub, Alain</creatorcontrib><title>Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points.
We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity.
A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Cell cycle</subject><subject>Cell fate</subject><subject>Cell proliferation</subject><subject>Cellular signal transduction</subject><subject>Cochlea</subject><subject>Cochlea - cytology</subject><subject>Cochlea - embryology</subject><subject>Cochlea - growth & development</subject><subject>Cochlea - metabolism</subject><subject>Cochlear Duct - cytology</subject><subject>Cochlear Duct - embryology</subject><subject>Cochlear Duct - growth & development</subject><subject>Cochlear Duct - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Embryos</subject><subject>Epithelium</subject><subject>Extracellular Space - metabolism</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Genetic engineering</subject><subject>Hair</subject><subject>Heparan sulfate</subject><subject>Homeostasis</subject><subject>Inner ear</subject><subject>Intracellular signalling</subject><subject>Intracellular Space - metabolism</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Ligands</subject><subject>Mammals</subject><subject>Maturation</subject><subject>Medicine and Health Sciences</subject><subject>Mesenchyme</subject><subject>Mice</subject><subject>Neonates</subject><subject>Otolaryngology</subject><subject>Otology</subject><subject>Polarity</subject><subject>Proteins</subject><subject>Regeneration</subject><subject>Regulators</subject><subject>Sensory epithelium</subject><subject>Signal transduction</subject><subject>Spatio-Temporal Analysis</subject><subject>Stria vascularis</subject><subject>Wnt protein</subject><subject>Wnt proteins</subject><subject>Wnt Proteins - antagonists & inhibitors</subject><subject>Wnt Signaling Pathway - genetics</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MVfcZILUrWUslKrIsrH0XKcSeIqsRc7Wdp_j9NNqw3qAfkQZ_zMO_ZrTxS9xGiJaYo_XNnBGdkuN9bAEmGWUZo_ig5xTsmCE0Qf780PomfeXyGU0Izzp9EB4VmSsxwdRmZlu42DBozXW4hPrsOP99qa2FbxL9PHl7oOVbSp46-yb_7Im_gUDPi4HNwY_ARbaO2mg4BKU8bnsh-c7CeBvoH43A4e4pVVTQvyefSkkq2HF9P3KPrx-eT76svi7OJ0vTo-Wyiek36hEoWypCBpmvAspYSnqChLzqBQLOUFQlUuUVVUGaBUIQqFpIwVhLICyoxkkh5Fr3e6m9Z6MVnlBU45wzShnAdivSNKK6_ExulOuhthpRa3AetqIV2vVQuCVmmoT0jwr2IY4zyhkmGVY6mqMitZ0Po4VRuKDkoVzHCynYnOV4xuRG23gqUsTRANAu8mAWd_D-B70WmvoG2lgWDf7b55niM87vvNP-jDp5uoWoYDaFPZUFeNouKYMZIxgkgWqOUDVBgldFqFd1XpEJ8lvJ8lBKaH676Wg_diffnt_9mLn3P27R7bgGz7xtt2GN-Rn4NsBypnvXdQ3ZuMkRjb4s4NMbaFmNoipL3av6D7pLs-oH8B7ewHyw</recordid><startdate>20160209</startdate><enddate>20160209</enddate><creator>Geng, Ruishuang</creator><creator>Noda, Teppei</creator><creator>Mulvaney, Joanna F</creator><creator>Lin, Vincent Y W</creator><creator>Edge, Albert S B</creator><creator>Dabdoub, Alain</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160209</creationdate><title>Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea</title><author>Geng, Ruishuang ; Noda, Teppei ; Mulvaney, Joanna F ; Lin, Vincent Y W ; Edge, Albert S B ; Dabdoub, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c5c085b277568732670bdd64ebc476b00f9a0fbf8e07c03eba344b234bed828a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Cell cycle</topic><topic>Cell fate</topic><topic>Cell proliferation</topic><topic>Cellular signal transduction</topic><topic>Cochlea</topic><topic>Cochlea - cytology</topic><topic>Cochlea - embryology</topic><topic>Cochlea - growth & development</topic><topic>Cochlea - metabolism</topic><topic>Cochlear Duct - cytology</topic><topic>Cochlear Duct - embryology</topic><topic>Cochlear Duct - growth & development</topic><topic>Cochlear Duct - metabolism</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Embryos</topic><topic>Epithelium</topic><topic>Extracellular Space - metabolism</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Genetic engineering</topic><topic>Hair</topic><topic>Heparan sulfate</topic><topic>Homeostasis</topic><topic>Inner ear</topic><topic>Intracellular signalling</topic><topic>Intracellular Space - metabolism</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Ligands</topic><topic>Mammals</topic><topic>Maturation</topic><topic>Medicine and Health Sciences</topic><topic>Mesenchyme</topic><topic>Mice</topic><topic>Neonates</topic><topic>Otolaryngology</topic><topic>Otology</topic><topic>Polarity</topic><topic>Proteins</topic><topic>Regeneration</topic><topic>Regulators</topic><topic>Sensory epithelium</topic><topic>Signal transduction</topic><topic>Spatio-Temporal Analysis</topic><topic>Stria vascularis</topic><topic>Wnt protein</topic><topic>Wnt proteins</topic><topic>Wnt Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geng, Ruishuang</au><au>Noda, Teppei</au><au>Mulvaney, Joanna F</au><au>Lin, Vincent Y W</au><au>Edge, Albert S B</au><au>Dabdoub, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-09</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0148339</spage><epage>e0148339</epage><pages>e0148339-e0148339</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis. In neonatal tissue Wnt signaling can drive proliferation of cells in the sensory region, suggesting that Wnt signaling could be used to regenerate the sensory epithelium in the damaged adult inner ear. Manipulation of Wnt signaling for regeneration will require an understanding of the dynamics of Wnt pathway gene expression in the ear. We present a comprehensive screen for 84 Wnt signaling related genes across four developmental and postnatal time points.
We identified 72 Wnt related genes expressed in the inner ear on embryonic day (E) 12.5, postnatal day (P) 0, P6 and P30. These genes included secreted Wnts, Wnt antagonists, intracellular components of canonical signaling and components of non-canonical signaling/planar cell polarity.
A large number of Wnt signaling molecules were dynamically expressed during cochlear development and in the early postnatal period, suggesting complex regulation of Wnt transduction. The data revealed several potential key regulators for further study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26859490</pmid><doi>10.1371/journal.pone.0148339</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals Biology Biology and Life Sciences Cell cycle Cell fate Cell proliferation Cellular signal transduction Cochlea Cochlea - cytology Cochlea - embryology Cochlea - growth & development Cochlea - metabolism Cochlear Duct - cytology Cochlear Duct - embryology Cochlear Duct - growth & development Cochlear Duct - metabolism Deoxyribonucleic acid DNA Embryos Epithelium Extracellular Space - metabolism Gene expression Gene Expression Regulation, Developmental Genes Genetic engineering Hair Heparan sulfate Homeostasis Inner ear Intracellular signalling Intracellular Space - metabolism Kinases Laboratories Ligands Mammals Maturation Medicine and Health Sciences Mesenchyme Mice Neonates Otolaryngology Otology Polarity Proteins Regeneration Regulators Sensory epithelium Signal transduction Spatio-Temporal Analysis Stria vascularis Wnt protein Wnt proteins Wnt Proteins - antagonists & inhibitors Wnt Signaling Pathway - genetics |
| title | Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea |
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