The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells

Cancer stem cells (CSCs) typically have the capacity to evade chemotherapy and may be the principal source of metastases. CSCs for human pancreatic ductal carcinoma (PDAC) have been identified, but neither the metastatic potential nor the chemoresistance of these cells has been adequately evaluated....

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148807
Hauptverfasser:	Bhagwandin, Vikash J, Bishop, J Michael, Wright, Woodring E, Shay, Jerry W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - pharmacology Apoptosis Biology Biology and Life Sciences Biotechnology Cancer Cancer metastasis Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Chemoresistance Chemotherapy Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Dose-Response Relationship, Drug Drug resistance Drug Resistance, Neoplasm Gemcitabine Humans Inhibition Laboratory animals Medicine and Health Sciences Metastases Metastasis Mice Neoplasm Transplantation Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - physiology Pancreatic cancer Pancreatic carcinoma Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Population Research and Analysis Methods Risk factors Spheroids Stem cell transplantation Stem cells Studies Tacca Tumors Verapamil Vincristine Xenografts
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