Congenic Strains Confirm the Pleiotropic Effect of Chromosome 4 QTL on Mouse Femoral Geometry and Biomechanical Performance

A pleiotropic quantitative trait locus (QTL) for bone geometry and mechanical performance in mice was mapped to distal chromosome 4 via an intercross of recombinant congenic mice HcB-8 and HcB-23. To study the QTL in isolation, we have generated C3H.B10-(rs6355453-rs13478087) (C.B.4.3) and C3H.B10-(...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148571-e0148571
Hauptverfasser:	Kristianto, Jasmin, Litscher, Suzanne J, Johnson, Michael G, Patel, Forum, Patel, Mital, Fisher, Jacqueline, Zastrow, Ryley K, Radcliff, Abigail B, Blank, Robert D
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological markers Biology and Life Sciences Biomechanical Phenomena Biomechanics Bone density Bone Density - genetics Chromosome 4 Chromosomes Chromosomes, Mammalian Displacement Female Females Femur Femur - anatomy & histology Femur - physiology Gene loci Gene mapping Genetic aspects Genomes Geometry Male Males Mathematical models Mechanical loading Mechanical properties Medicine Medicine and Health Sciences Mice Mice, Congenic Mice, Inbred C3H Mice, Inbred C57BL Osteoporosis Physical Sciences Principal components analysis Public health Quantitative genetics Quantitative Trait Loci Sex Stiffness Strains (organisms) Variance analysis
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