Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy
Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC) in transrectal ultraso...
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| creator | Lee, Young Ik Lee, Hak Min Jo, Jung Ki Lee, Sangchul Hong, Sung Kyu Byun, Seok-Soo Lee, Sang Eun Oh, Jong Jin |
| description | Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC) in transrectal ultrasound (TRUS) -guided biopsies compared with anteromiddle dominant prostate cancer (AMPC).
From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa) patients who underwent radical prostatectomy (RP) were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR). We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI) and Cox proportional hazard analysis to BCR.
Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p |
| doi_str_mv | 10.1371/journal.pone.0148690 |
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From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa) patients who underwent radical prostatectomy (RP) were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR). We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI) and Cox proportional hazard analysis to BCR.
Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p<0.001), a higher biopsy GS (p = 0.002), and a higher rate of extracapsular extension (ECE), SVI and BCR (all p<0.001) than AMPC group. The patients in BDPC group had poor BCR free survival rate via Kaplan-meier analysis (p<0.001). The ratio of the base positive cores was a significant predictor to SVI in multivariate analysis (p < 0.001) and significant predictor of BCR in multivariate Cox proportional analysis (hazard ratio: 1.466, p = 0.004).
BDPC in TRUS-guided prostate biopsies was significantly associated with SVI and BCR after adjusting for other clinical factors. Therefore, BDPC should be considered to be a more aggressive tumor despite an otherwise similar cancer profile.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0148690</identifier><identifier>PMID: 26848747</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Antigens ; Biology and Life Sciences ; Biopsy ; Cancer ; Cancer surgery ; Care and treatment ; Cores ; Diagnosis ; Fibroblasts ; Hazard assessment ; Health aspects ; Health risks ; Humans ; Male ; Medical prognosis ; Medicine and Health Sciences ; Methods ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness ; Neoplasm Staging ; NMR ; Nuclear magnetic resonance ; Patients ; Physiological aspects ; Proportional Hazards Models ; Prostate cancer ; Prostate-Specific Antigen - metabolism ; Prostatectomy ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - surgery ; Regression analysis ; Regression models ; Research and Analysis Methods ; Retrospective Studies ; Seminal vesicle ; Seminal Vesicles - pathology ; Studies ; Survival ; Tumors ; Ultrasonic imaging ; Ultrasound ; Urological surgery ; Urology</subject><ispartof>PloS one, 2016-02, Vol.11 (2), p.e0148690-e0148690</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Lee et al 2016 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a04adb2a0b08a52586ed5d38b05cad98607082176383d76fcc9dced151c4d1e83</citedby><cites>FETCH-LOGICAL-c692t-a04adb2a0b08a52586ed5d38b05cad98607082176383d76fcc9dced151c4d1e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743841/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743841/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26848747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Young Ik</creatorcontrib><creatorcontrib>Lee, Hak Min</creatorcontrib><creatorcontrib>Jo, Jung Ki</creatorcontrib><creatorcontrib>Lee, Sangchul</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Oh, Jong Jin</creatorcontrib><title>Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC) in transrectal ultrasound (TRUS) -guided biopsies compared with anteromiddle dominant prostate cancer (AMPC).
From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa) patients who underwent radical prostatectomy (RP) were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR). We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI) and Cox proportional hazard analysis to BCR.
Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p<0.001), a higher biopsy GS (p = 0.002), and a higher rate of extracapsular extension (ECE), SVI and BCR (all p<0.001) than AMPC group. The patients in BDPC group had poor BCR free survival rate via Kaplan-meier analysis (p<0.001). The ratio of the base positive cores was a significant predictor to SVI in multivariate analysis (p < 0.001) and significant predictor of BCR in multivariate Cox proportional analysis (hazard ratio: 1.466, p = 0.004).
BDPC in TRUS-guided prostate biopsies was significantly associated with SVI and BCR after adjusting for other clinical factors. Therefore, BDPC should be considered to be a more aggressive tumor despite an otherwise similar cancer profile.</description><subject>Aged</subject><subject>Antigens</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Care and treatment</subject><subject>Cores</subject><subject>Diagnosis</subject><subject>Fibroblasts</subject><subject>Hazard assessment</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Proportional Hazards Models</subject><subject>Prostate cancer</subject><subject>Prostate-Specific Antigen - metabolism</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - surgery</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Research and Analysis Methods</subject><subject>Retrospective Studies</subject><subject>Seminal vesicle</subject><subject>Seminal Vesicles - pathology</subject><subject>Studies</subject><subject>Survival</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Urological surgery</subject><subject>Urology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0WLHTuLcTCrlq1LR0LqNS-vEPmlTpXaJ3Y3-Hv4oTj-mFu0C5cKR_bzvOT4-J4peUtKnLKcf5nbVGmj6S2uwTygXWUEeRae0YEkvSwh7fPB_Ej1zbk5IykSWPY1OkkxwkfP8NPozcM6qGnxtTVyiv0M08QQXdbCOb9DVqsF4ZG7BdQAYHf9orfPgMR6CUdjGn9Cj2sjHVm19oPLh4KoF49pwFpwma-eDqYo_1nbp1jEsrJnG30OsnzMbXxuN7R0aH1-CrlXg90GUt4v18-hJBY3DF7v1LLr-8vlq-K03vvg6Gg7GPZUVie8B4aDLBEhJBKRJKjLUqWaiJKkCXYiM5EQkNM-YYDrPKqUKrVDTlCquKQp2Fr3e-i4b6-Suvk4GRSIYFSILxGhLaAtzuWzrBbRraaGWmw3bTiW0vquZTAWrKlUWAILzAkXBGa0IKwFzSFHw4HW-i7YqFxgyMb6F5sj0-MTUMzm1t5LnnAlOg8G7nUFrf63QebmoncKmAYN2tck7UCHzLtabf9CHb7ejphAuUJvKhriqM5UDzhNe5CQrAtV_gAqf7h44NGNVh_0jwfsjQWA8_vZTWDknR5PL_2cvbo7ZtwfsDKHxM2ebVdeC7hjkW1CFrgodWd0XmRLZzdK-GrKbJbmbpSB7dfhA96L98LC_AYQc8Q</recordid><startdate>20160205</startdate><enddate>20160205</enddate><creator>Lee, Young Ik</creator><creator>Lee, Hak Min</creator><creator>Jo, Jung Ki</creator><creator>Lee, Sangchul</creator><creator>Hong, Sung Kyu</creator><creator>Byun, Seok-Soo</creator><creator>Lee, Sang Eun</creator><creator>Oh, Jong Jin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160205</creationdate><title>Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy</title><author>Lee, Young Ik ; Lee, Hak Min ; Jo, Jung Ki ; Lee, Sangchul ; Hong, Sung Kyu ; Byun, Seok-Soo ; Lee, Sang Eun ; Oh, Jong Jin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a04adb2a0b08a52586ed5d38b05cad98607082176383d76fcc9dced151c4d1e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Antigens</topic><topic>Biology and Life Sciences</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Care and treatment</topic><topic>Cores</topic><topic>Diagnosis</topic><topic>Fibroblasts</topic><topic>Hazard assessment</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Proportional Hazards Models</topic><topic>Prostate cancer</topic><topic>Prostate-Specific Antigen - metabolism</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - surgery</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Research and Analysis Methods</topic><topic>Retrospective Studies</topic><topic>Seminal vesicle</topic><topic>Seminal Vesicles - pathology</topic><topic>Studies</topic><topic>Survival</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Urological surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Young Ik</creatorcontrib><creatorcontrib>Lee, Hak Min</creatorcontrib><creatorcontrib>Jo, Jung Ki</creatorcontrib><creatorcontrib>Lee, Sangchul</creatorcontrib><creatorcontrib>Hong, Sung Kyu</creatorcontrib><creatorcontrib>Byun, Seok-Soo</creatorcontrib><creatorcontrib>Lee, Sang Eun</creatorcontrib><creatorcontrib>Oh, Jong Jin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Young Ik</au><au>Lee, Hak Min</au><au>Jo, Jung Ki</au><au>Lee, Sangchul</au><au>Hong, Sung Kyu</au><au>Byun, Seok-Soo</au><au>Lee, Sang Eun</au><au>Oh, Jong Jin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-02-05</date><risdate>2016</risdate><volume>11</volume><issue>2</issue><spage>e0148690</spage><epage>e0148690</epage><pages>e0148690-e0148690</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC) in transrectal ultrasound (TRUS) -guided biopsies compared with anteromiddle dominant prostate cancer (AMPC).
From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa) patients who underwent radical prostatectomy (RP) were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR). We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI) and Cox proportional hazard analysis to BCR.
Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p<0.001), a higher biopsy GS (p = 0.002), and a higher rate of extracapsular extension (ECE), SVI and BCR (all p<0.001) than AMPC group. The patients in BDPC group had poor BCR free survival rate via Kaplan-meier analysis (p<0.001). The ratio of the base positive cores was a significant predictor to SVI in multivariate analysis (p < 0.001) and significant predictor of BCR in multivariate Cox proportional analysis (hazard ratio: 1.466, p = 0.004).
BDPC in TRUS-guided prostate biopsies was significantly associated with SVI and BCR after adjusting for other clinical factors. Therefore, BDPC should be considered to be a more aggressive tumor despite an otherwise similar cancer profile.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26848747</pmid><doi>10.1371/journal.pone.0148690</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Antigens Biology and Life Sciences Biopsy Cancer Cancer surgery Care and treatment Cores Diagnosis Fibroblasts Hazard assessment Health aspects Health risks Humans Male Medical prognosis Medicine and Health Sciences Methods Middle Aged Multivariate Analysis Neoplasm Invasiveness Neoplasm Staging NMR Nuclear magnetic resonance Patients Physiological aspects Proportional Hazards Models Prostate cancer Prostate-Specific Antigen - metabolism Prostatectomy Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery Regression analysis Regression models Research and Analysis Methods Retrospective Studies Seminal vesicle Seminal Vesicles - pathology Studies Survival Tumors Ultrasonic imaging Ultrasound Urological surgery Urology |
| title | Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T06%3A18%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20Seminal%20Vesicle%20Invasion%20and%20Prostate%20Cancer%20Detection%20Location%20after%20Transrectal%20Systemic%20Biopsy%20among%20Men%20Who%20Underwent%20Radical%20Prostatectomy&rft.jtitle=PloS%20one&rft.au=Lee,%20Young%20Ik&rft.date=2016-02-05&rft.volume=11&rft.issue=2&rft.spage=e0148690&rft.epage=e0148690&rft.pages=e0148690-e0148690&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0148690&rft_dat=%3Cgale_plos_%3EA442497069%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1762831886&rft_id=info:pmid/26848747&rft_galeid=A442497069&rft_doaj_id=oai_doaj_org_article_583ffcb9aa8449e89431f03bae7a5e84&rfr_iscdi=true |