The Effect of (-)-Epigallocatechin-3-Gallate on IL-1β Induced IL-8 Expression in Orbital Fibroblast from Patients with Thyroid-Associated Ophthalmopathy

Orbital fibroblasts have been reported to be an important effector cells for the development of thyroid-associated ophthalmopathy (TAO). Orbital fibroblasts secrete various inflammatory cytokines in response to an inflammatory stimulation, leading to TAO-related tissue swelling. It has also been rep...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148645-e0148645
Hauptverfasser:	Lee, Ji-Young, Paik, Ji-Sun, Yun, Mihee, Lee, Seong-Beom, Yang, Suk-Woo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Antioxidants Antioxidants - pharmacology Biology and Life Sciences Cancer Catechin - analogs & derivatives Catechin - pharmacology Cytokines Degradation Disease Effector cells Epigallocatechin gallate Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Gene expression Graves Ophthalmopathy - metabolism Graves Ophthalmopathy - pathology Graves' disease Green tea Hospitals Humans Immunoglobulins Inflammation Interleukin 8 Interleukin-1beta - metabolism Interleukin-8 - metabolism Kinases MAP Kinase Signaling System Medicine Medicine and Health Sciences Metabolic pathways mRNA NF-kappa B - metabolism NF-kappa B - physiology NF-κB protein p38 Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases - physiology Pathogenesis Pathology Patients Pharmacology Phosphorylation Reactive Oxygen Species - metabolism Research and analysis methods Tea Thyroid Thyroid gland Tumor necrosis factor-TNF
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