A New Computational Model for Neuro-Glio-Vascular Coupling: Astrocyte Activation Can Explain Cerebral Blood Flow Nonlinear Response to Interictal Events

Developing a clear understanding of the relationship between cerebral blood flow (CBF) response and neuronal activity is of significant importance because CBF increase is essential to the health of neurons, for instance through oxygen supply. This relationship can be investigated by analyzing multim...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0147292-e0147292
Hauptverfasser:	Blanchard, Solenna, Saillet, Sandrine, Ivanov, Anton, Benquet, Pascal, Bénar, Christian-George, Pélégrini-Issac, Mélanie, Benali, Habib, Wendling, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Algorithms Alzheimer's disease Analysis Animals Astrocytes Astrocytes - physiology Bicuculline Biology and Life Sciences Blood Blood flow Blood vessels Blood Vessels - physiology Brain - blood supply Brain - physiology Cerebral blood flow Cerebral circulation Cerebrovascular Circulation Cerebrum Computation Computational neuroscience Computer Simulation Coupling Discharge Disease Models, Animal Electrophysiological recording Engineering and Technology Engineering Sciences Epilepsy Epilepsy - physiopathology Firing pattern Functional magnetic resonance imaging gamma-Aminobutyric Acid - metabolism Glial cells Glutamic Acid - metabolism Hemodynamics In vivo methods and tests Lasers Low level Medicine and Health Sciences Metabolism Models, Biological Neural networks Neuroglia - physiology Neuronal-glial interactions Neurons - physiology Neurosciences Neurotransmitter Agents - metabolism Nonlinear response Nonlinear systems Nonlinearity Oxygen Physiological aspects Physiology Positron emission Positron emission tomography Rats Tomography γ-Aminobutyric acid
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