Adiponectin Upregulates MiR-133a in Cardiac Hypertrophy through AMPK Activation and Reduced ERK1/2 Phosphorylation

Adiponectin and miR-133a are key regulators in cardiac hypertrophy. However, whether APN has a potential effect on miR-133a remains unclear. In this study, we aimed to investigate whether APN could regulate miR-133a expression in Angiotensin II (Ang II) induced cardiac hypertrophy in vivo and in vit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148482-e0148482
Hauptverfasser:	Li, Ying, Cai, Xiaojun, Guan, Yuqing, Wang, Lei, Wang, Shuya, Li, Yueyan, Fu, Ying, Gao, Xiaoyuan, Su, Guohai
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adiponectin Adiponectin - genetics Adiponectin - metabolism AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Angiogenesis Angiotensin Angiotensin II Angiotensin II - adverse effects Animals Apoptosis Atrial natriuretic peptide Biology and Life Sciences Brain Brain natriuretic peptide Cardiac muscle Cardiology Cardiomegaly - chemically induced Cardiomegaly - diagnosis Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomyocytes Cardiovascular disease Cell growth Cell surface Connective tissue growth factor Connective Tissue Growth Factor - genetics Connective Tissue Growth Factor - metabolism Connective tissues Development and progression Diabetes Disease Models, Animal Echocardiography - methods Extracellular signal-regulated kinase Gene Expression Gene Expression Regulation Genetic aspects Genetic Vectors - genetics Growth factors Heart Heart diseases Heart failure Heart hypertrophy Hospitals Hypertension Hypertrophy Infusion Inhibition Inhibitors Kinases Lentivirus - genetics Male Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Molecular modelling Myocytes Myocytes, Cardiac - metabolism Neonates Oxidation Pathology Peptide hormones Phosphorylation Physiological aspects Proteins Rats Receptors, Adiponectin - metabolism Regulators Research and Analysis Methods Ribonucleic acid RNA Rodents Signal Transduction Stimulation Surface area Transduction, Genetic Up-Regulation Ventricle Wall thickness Ying Li
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!