Therapeutic Benefits of Induced Pluripotent Stem Cells in Monocrotaline-Induced Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is characterized by progressive increases in vascular resistance and the remodeling of pulmonary arteries. The accumulation of inflammatory cells in the lung and elevated levels of inflammatory cytokines in the bloodstream suggest that inflammation may play a ro...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0142476
Hauptverfasser:	Huang, Wei-Chun, Ke, Meng-Wei, Cheng, Chin-Chang, Chiou, Shih-Hwa, Wann, Shue-Ren, Shu, Chih-Wen, Chiou, Kuan-Rau, Tseng, Ching-Jiunn, Pan, Hung-Wei, Mar, Guang-Yuan, Liu, Chun-Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adult Animals Arteries Binding sites Biology and Life Sciences Blood pressure Cells, Cultured Conditioning Culture Media, Conditioned Cytokines Cytokines - metabolism Disease Models, Animal Down-Regulation Gene expression Glycoproteins Health education Heart Heart attacks Humans Hypertension Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Hypertension, Pulmonary - therapy Hypertrophy Hypertrophy, Right Ventricular - therapy Inflammation Inflammation - genetics Inflammation - therapy Inhibitory postsynaptic potentials Interferon-gamma - genetics Interleukin 23 Interleukin 6 Interleukins - genetics Lung - pathology Lungs Macrophages Macrophages - metabolism Male Medicine Medicine and Health Sciences Monocrotaline NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB protein Phosphatase Phosphorylation Physical therapy Pluripotency Pluripotent Stem Cells - transplantation Prevention Pulmonary artery Pulmonary Artery - pathology Pulmonary hypertension Rats Recovery of function Research and Analysis Methods Rodents Stem cells Systolic pressure Ventricle γ-Interferon
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