Conditional Deletion of Fgfr1 in the Proximal and Distal Tubule Identifies Distinct Roles in Phosphate and Calcium Transport

A postnatal role of fibroblast growth factor receptor-1 (FGFR1) in the kidney is suggested by its binding to α-Klotho to form an obligate receptor for the hormone fibroblast growth factor-23 (FGF-23). FGFR1 is expressed in both the proximal and distal renal tubular segments, but its tubular specific...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0147845-e0147845
Hauptverfasser:	Han, Xiaobin, Yang, Jiancheng, Li, Linqiang, Huang, Jinsong, King, Gwendalyn, Quarles, L Darryl
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological Transport - genetics Biology and Life Sciences Bone and Bones - abnormalities Calcinosis - genetics Calcium Calcium - blood Calcium - metabolism Calcium - urine Calcium Channels - metabolism Calcium homeostasis Calcium phosphates Calcium transport Cancer Cortical bone Excretion Fibroblast growth factor 23 Fibroblast growth factor receptor 1 Fibroblast growth factors Fibroblast Growth Factors - metabolism Fibroblasts Flox Gene Deletion Genetic aspects Glucuronidase - metabolism Growth factors Homeostasis Hypercalciuria Hypercalciuria - genetics Hyperphosphatemia Hyperphosphatemia - genetics Hypophosphatemia Hypophosphatemia - genetics Ion Transport - genetics Kidney Tubules, Distal - physiopathology Kidney Tubules, Proximal - physiopathology Kidneys Kinases Klotho protein Mammals Medical research Medicine Medicine and Health Sciences Metabolism Mice Mice, Inbred C57BL Mice, Knockout Parathyroid Parathyroid hormone Parathyroid Hormone - metabolism Parathyroid hormones Phosphate Phosphates Phosphates - blood Phosphates - metabolism Phosphates - urine Physical Sciences Physiological aspects Physiology Reabsorption Receptor, Fibroblast Growth Factor, Type 1 - genetics Research and Analysis Methods Rodents Science Sodium Spina bifida Spinal Dysraphism - genetics Studies Thermal resistance TRPV Cation Channels - metabolism γ-Glutamyltransferase
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