Identification of Eight Different Isoforms of the Glucocorticoid Receptor in Guinea Pig Placenta: Relationship to Preterm Delivery, Sex and Betamethasone Exposure

The placental glucocorticoid receptor (GR) is central to glucocorticoid signalling and for mediating steroid effects on pathways associated with fetal growth and lung maturation but the GR has not been examined in the guinea pig placenta even though this animal is regularly used as a model of preter...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148226-e0148226
Hauptverfasser:	Saif, Zarqa, Dyson, Rebecca M, Palliser, Hannah K, Wright, Ian M R, Lu, Nick, Clifton, Vicki L
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age differences Analysis Animals Asthma Babies Betamethasone Betamethasone - pharmacology Biology and Life Sciences Cytoplasm Dehydrogenases Delivery (Childbirth) DNA methylation Dosage and administration Endocrinology Exposure Female Females Fetal Development Fetuses Gestational Age Glucocorticoid receptors Glucocorticoids Glycoproteins Guinea Pigs Health aspects Hormones Isoforms Leukemia Lungs Male Males Medical research Medicine and Health Sciences Mothers Nuclei Physical Sciences Placenta Placenta - metabolism Pregnancy Premature birth Premature Birth - metabolism Protein Isoforms - biosynthesis Protein Isoforms - genetics Receptors, Glucocorticoid - biosynthesis Receptors, Glucocorticoid - genetics Reproductive health Research and Analysis Methods Sex Sex Factors Signal transduction Term Birth - metabolism Variance analysis
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