Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils

Psammomys obesus gerbils are particularly prone to develop diabetes and obesity after brief period of abundant food intake. A hypercaloric high fat diet has been shown to affect cardiac function. Here, we sought to determine whether a short period of high fat feeding might alter myocardial structure...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148117
Hauptverfasser:	Sahraoui, Abdelhamid, Dewachter, Céline, de Medina, Geoffrey, Naeije, Robert, Aouichat Bouguerra, Souhila, Dewachter, Laurence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis BAX protein Bcl-2 protein bcl-2-Associated X Protein - biosynthesis Biology and Life Sciences Body weight Body weight gain Ca2+-transporting ATPase Ca2+/calmodulin-dependent protein kinase Calcium Calcium channels (voltage-gated) Calcium Channels - biosynthesis Calcium-binding protein Calmodulin Carbohydrates Cardiac muscle Cardiomyocytes Cardiomyopathy Cardiovascular disease Complications and side effects Cytokines Deserts Diabetes Diabetes mellitus Diet Dietary Fats - adverse effects Dietary Fats - pharmacology Eating Endoplasmic reticulum Fatty acids Fibrosis Food intake Gerbillinae Heart diseases Heart failure High fat diet Hyperlipidemia Hyperlipidemias - chemically induced Hyperlipidemias - metabolism Hyperlipidemias - mortality Hypertrophy IL-1β Inflammation Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - biosynthesis Interleukin Interleukin-1beta - biosynthesis Interleukins Laboratories Leukocytes (neutrophilic) Lipids Medicine Medicine and Health Sciences Metabolism Myocardium - metabolism Myocardium - pathology Myosin Myosin Heavy Chains - biosynthesis Na+/Ca2+ exchanger Na+/Ca2+-exchanging ATPase Obesity Obesity - chemically induced Obesity - metabolism Obesity - pathology Pharmacology Physiological aspects Physiology Proteins Psammomys obesus Risk factors Rodents Sarcoplasmic Reticulum Calcium-Transporting ATPases - biosynthesis Social Sciences Sodium Tumor Necrosis Factor-alpha - biosynthesis Vascular Cell Adhesion Molecule-1 - biosynthesis
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