Transcription Factors Oct-1 and GATA-3 Cooperatively Regulate Th2 Cytokine Gene Expression via the RHS5 within the Th2 Locus Control Region

The T helper type 2 (Th2) locus control region (LCR) regulates Th2 cell differentiation. Several transcription factors bind to the LCR to modulate the expression of Th2 cytokine genes, but the molecular mechanisms behind Th2 cytokine gene regulation are incompletely understood. Here, we used databas...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148576-e0148576
Hauptverfasser:	Kim, Kiwan, Kim, Najung, Lee, Gap Ryol
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biology and Life Sciences Cell differentiation Cell Line Chromatin Cytokines Deoxyribonuclease Electrophoretic mobility Epigenetics ETS protein GATA-3 protein GATA-binding protein GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene expression Gene Expression Regulation - physiology Gene regulation Genetic aspects Genetic regulation Genetic transformation Helper cells Immunology Immunoprecipitation Interleukin 4 Interleukin-4 - biosynthesis Interleukin-4 - genetics Life sciences Locus Control Region - physiology Lymphocytes Lymphocytes T Medical research Medicine and Health Sciences Mice Molecular modelling Oct-1 protein Octamer Transcription Factor-1 - genetics Octamer Transcription Factor-1 - metabolism Oligonucleotides Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Organic Cation Transporter 2 Penicillin Physical Sciences Physiological aspects Proteins Research and Analysis Methods Rodents T cell receptors Th2 Cells - cytology Th2 Cells - metabolism Transcription factors Transformation Transgenic animals
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