Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling

Uptake of Ca2+ into the mitochondrial matrix controls cellular metabolism and survival-death pathways. Several genes are implicated in controlling mitochondrial Ca2+ uptake (mitochondrial calcium regulatory genes, MCRGs), however, less is known about the factors which influence their expression leve...

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Veröffentlicht in:	PloS one 2016-02, Vol.11 (2), p.e0148164-e0148164
Hauptverfasser:	Márkus, Nóra M, Hasel, Philip, Qiu, Jing, Bell, Karen F S, Heron, Samuel, Kind, Peter C, Dando, Owen, Simpson, T Ian, Hardingham, Giles E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Astrocytes Astrocytes - metabolism Biology and Life Sciences Calcium Calcium (mitochondrial) Calcium - metabolism Calcium Channels - genetics Calcium Channels - metabolism Calcium influx Calcium Signaling - genetics Calcium signalling Cell survival Cells, Cultured Depolarization Dynamic control Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genomes Hippocampus Hippocampus - metabolism Informatics Kinases Medicine and Health Sciences Membrane potential Metabolism Mice Mitochondria Mitochondria - metabolism Neurons Neurons - metabolism Physiology Proteins Research and analysis methods Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sequence Analysis, RNA Stem cells
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