The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy

Pulmonary arterial hypertension is characterized by increased pressure overload that leads to right ventricular hypertrophy (RVH). GPR91 is a formerly orphan G-protein-coupled receptor (GPCR) that has been characterized as a receptor for succinate; however, its role in RVH remains unknown. We invest...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0147597-e0147597
Hauptverfasser:	Yang, Lei, Yu, Di, Mo, Ran, Zhang, Jiru, Hua, Hu, Hu, Liang, Feng, Yu, Wang, Song, Zhang, Wei-Yan, Yin, Ning, Mo, Xu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Androstadienes - pharmacology Anesthesiology Animals Atrial Natriuretic Factor - genetics Atrial Natriuretic Factor - metabolism Banding Biology and Life Sciences Cancer Cardiomyocytes Cell receptors Children & youth Diabetes Diagnosis G protein-coupled receptors Gene Expression Regulation Genetic aspects Genetic markers Heart Heart failure Heart hypertrophy Heart surgery Heart Ventricles - metabolism Heart Ventricles - pathology Heart Ventricles - physiopathology Hospitals Humans Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Hypertension, Pulmonary - physiopathology Hypertrophy Hypertrophy, Right Ventricular - genetics Hypertrophy, Right Ventricular - metabolism Hypertrophy, Right Ventricular - pathology Hypertrophy, Right Ventricular - physiopathology Kinases Medicine and Health Sciences Metabolism Metabolites Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Pulmonary arteries Pulmonary Artery - metabolism Pulmonary Artery - pathology Pulmonary Artery - surgery Pulmonary hypertension Rats Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Rodents Signal Transduction Signaling Stroke Volume Succinic Acid - metabolism Succinic Acid - pharmacology Ventricle Wortmannin
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