Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure
The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum sa...
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| creator | Wakabayashi, Ichiro Marumo, Mikio Nonaka, Daisuke Shimomura, Tomoko Eguchi, Ryoji Lee, Lyang-Ja Tanaka, Kenji Hatake, Katsuhiko |
| description | The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. The intensities of the m/z 2380 and m/z 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the m/z 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol. |
| doi_str_mv | 10.1371/journal.pone.0147297 |
| format | Article |
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Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. The intensities of the m/z 2380 and m/z 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the m/z 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0147297</identifier><identifier>PMID: 26815288</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alcohol Drinking - blood ; Alcoholism ; Alcohols ; Alzheimer's disease ; Biochemistry ; Bioinformatics ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Blood ; Blood pressure ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Blood Pressure Determination ; Cardiovascular disease ; Complement C4 - metabolism ; Complement component C4 ; Complications and side effects ; Dehydrogenases ; Disease prevention ; Drinking ; Drinking (Alcoholic beverages) ; Drinking behavior ; Ethanol ; Ethanol - pharmacology ; Experiments ; Fibrinogen ; Fibrinogen - metabolism ; Health care ; Humans ; Hypertension ; Hypotheses ; Legal medicine ; Ligands ; Male ; Mass spectrometry ; Medicine and Health Sciences ; Middle Aged ; Peptide Fragments - blood ; Peptides ; Pharmacology ; Physical Sciences ; Physiological aspects ; Preventive medicine ; Proteins ; Proteomics ; Questionnaires ; Reduction ; Research and Analysis Methods ; Scientific imaging ; Wine ; Wines</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0147297-e0147297</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Wakabayashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Wakabayashi et al 2016 Wakabayashi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e7d25b8bab26bd232e418eeb1b14182e34c8e1c6d7309082003e07ad3e3fd9253</citedby><cites>FETCH-LOGICAL-c692t-e7d25b8bab26bd232e418eeb1b14182e34c8e1c6d7309082003e07ad3e3fd9253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729683/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729683/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26815288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jeyaseelan, Kandiah</contributor><creatorcontrib>Wakabayashi, Ichiro</creatorcontrib><creatorcontrib>Marumo, Mikio</creatorcontrib><creatorcontrib>Nonaka, Daisuke</creatorcontrib><creatorcontrib>Shimomura, Tomoko</creatorcontrib><creatorcontrib>Eguchi, Ryoji</creatorcontrib><creatorcontrib>Lee, Lyang-Ja</creatorcontrib><creatorcontrib>Tanaka, Kenji</creatorcontrib><creatorcontrib>Hatake, Katsuhiko</creatorcontrib><title>Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. 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The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol.</description><subject>Adult</subject><subject>Alcohol Drinking - blood</subject><subject>Alcoholism</subject><subject>Alcohols</subject><subject>Alzheimer's disease</subject><subject>Biochemistry</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Blood Pressure Determination</subject><subject>Cardiovascular disease</subject><subject>Complement C4 - metabolism</subject><subject>Complement component C4</subject><subject>Complications and side effects</subject><subject>Dehydrogenases</subject><subject>Disease prevention</subject><subject>Drinking</subject><subject>Drinking (Alcoholic beverages)</subject><subject>Drinking behavior</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Experiments</subject><subject>Fibrinogen</subject><subject>Fibrinogen - metabolism</subject><subject>Health care</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypotheses</subject><subject>Legal medicine</subject><subject>Ligands</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Peptide Fragments - blood</subject><subject>Peptides</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Preventive medicine</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Questionnaires</subject><subject>Reduction</subject><subject>Research and Analysis Methods</subject><subject>Scientific imaging</subject><subject>Wine</subject><subject>Wines</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1tv0zAUxyMEYqPwDRBEQkLw0OJbEucFqZu4VJq0alwesRz7pHVx42I7XL49zppNLdoD8oMt-3f-9vn7nCx7itEM0wq_2bjed9LOdq6DGcKsInV1LzvFNSXTkiB6_2B9kj0KYYNQQXlZPsxOSMlxQTg_zb4tXYQuGmnzM-O20n8Hny9hF42GkM9DcMrICDr_ZeI6n6s-Qj63yq2dnS463at0dAVpjsZ1uWvzM-uczpceQug9PM4etNIGeDLOk-zL-3efzz9OLy4_LM7nF1NV1iROodKkaHgjG1I2mlACDHOABjc4LQhQpjhgVeqKohpxghAFVElNgba6JgWdZM_3ujvrghitCQJXJeIp52TEJFvsCe3kRuy8Sbn-EU4acb3h_EpIH42yIIpaNgUDSH4VTJK61gy4wpJSRQhqaNJ6O97WN1vQKhnopT0SPT7pzFqs3E8xfFLJB4FXo4B3P3oIUWxNUGCt7MD11-_GrOBVRRL64h_07uxGaiVTAqZrXbpXDaJizhguGOGEJWp2B5WGhq1RqY5ak_aPAl4fBSQmwu-4kn0IYvHp6v_Zy6_H7MsDdg3SxnVwth-KKByDbA8q70Lw0N6ajJEY2uDGDTG0gRjbIIU9O_yg26Cbuqd_AavCAb0</recordid><startdate>20160127</startdate><enddate>20160127</enddate><creator>Wakabayashi, Ichiro</creator><creator>Marumo, Mikio</creator><creator>Nonaka, Daisuke</creator><creator>Shimomura, Tomoko</creator><creator>Eguchi, Ryoji</creator><creator>Lee, Lyang-Ja</creator><creator>Tanaka, Kenji</creator><creator>Hatake, Katsuhiko</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160127</creationdate><title>Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure</title><author>Wakabayashi, Ichiro ; Marumo, Mikio ; Nonaka, Daisuke ; Shimomura, Tomoko ; Eguchi, Ryoji ; Lee, Lyang-Ja ; Tanaka, Kenji ; Hatake, Katsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-e7d25b8bab26bd232e418eeb1b14182e34c8e1c6d7309082003e07ad3e3fd9253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Alcohol Drinking - 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Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. The intensities of the m/z 2380 and m/z 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the m/z 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26815288</pmid><doi>10.1371/journal.pone.0147297</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alcohol Drinking - blood Alcoholism Alcohols Alzheimer's disease Biochemistry Bioinformatics Biology and Life Sciences Biomarkers Biomarkers - blood Blood Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Blood Pressure Determination Cardiovascular disease Complement C4 - metabolism Complement component C4 Complications and side effects Dehydrogenases Disease prevention Drinking Drinking (Alcoholic beverages) Drinking behavior Ethanol Ethanol - pharmacology Experiments Fibrinogen Fibrinogen - metabolism Health care Humans Hypertension Hypotheses Legal medicine Ligands Male Mass spectrometry Medicine and Health Sciences Middle Aged Peptide Fragments - blood Peptides Pharmacology Physical Sciences Physiological aspects Preventive medicine Proteins Proteomics Questionnaires Reduction Research and Analysis Methods Scientific imaging Wine Wines |
| title | Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T06%3A49%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20Biomarker%20Peptides%20Associated%20with%20Acute%20Alcohol-Induced%20Reduction%20of%20Blood%20Pressure&rft.jtitle=PloS%20one&rft.au=Wakabayashi,%20Ichiro&rft.date=2016-01-27&rft.volume=11&rft.issue=1&rft.spage=e0147297&rft.epage=e0147297&rft.pages=e0147297-e0147297&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0147297&rft_dat=%3Cgale_plos_%3EA441542824%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1760838619&rft_id=info:pmid/26815288&rft_galeid=A441542824&rft_doaj_id=oai_doaj_org_article_59ab54ee00554a299d4e8c1a33c220b3&rfr_iscdi=true |