The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

The entry of HIV into its host cell is an interesting target for chemotherapeutic intervention in the life-cycle of the virus. During entry, reduction of disulfide bridges in the viral envelope glycoprotein gp120 by cellular oxidoreductases is crucial. The cellular thioredoxin reductase-1 plays an i...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0147773-e0147773
Hauptverfasser:	Reiser, Kathrin, Mathys, Leen, Curbo, Sophie, Pannecouque, Christophe, Noppen, Sam, Liekens, Sandra, Engman, Lars, Lundberg, Mathias, Balzarini, Jan, Karlsson, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Antiviral Agents - chemistry Antiviral Agents - pharmacology Biology and Life Sciences Cancer therapies CD4 antigen Cell culture Cell Line Chemical bonds Drug resistance Drug therapy Enfuvirtide Enzymes Genetic aspects Glycoprotein gp120 Glycoprotein gp41 Glycoproteins Health aspects HIV HIV Envelope Protein gp120 - metabolism HIV infections HIV Infections - drug therapy HIV Infections - metabolism HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Humans Infections Inhibition Inhibitors Laboratories Localization Medical research Medicin och hälsovetenskap Medicine Medicine and Health Sciences Oxidation-Reduction - drug effects Physiological aspects Proteins Reductase Reduction Research and Analysis Methods Rheumatoid arthritis Surface plasmon resonance Tellurium Tellurium - chemistry Tellurium - pharmacology Thioredoxin Thioredoxin Reductase 1 - antagonists & inhibitors Thioredoxin Reductase 1 - metabolism Thioredoxins Thioredoxins - metabolism Virus Internalization - drug effects Virus replication Viruses
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