Depressed Hypoxic and Hypercapnic Ventilatory Responses at Early Stage of Lethal Avian Influenza A Virus Infection in Mice

H5N1 virus infection results in ~60% mortality in patients primarily due to respiratory failure, but the underlying causes of mortality are unclear. The goal of this study is to reveal respiratory disorders occurring at the early stage of infection that may be responsible for subsequent respiratory...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0147522-e0147522
Hauptverfasser:	Zhuang, Jianguo, Gao, Peng, Pollock, Zemmie, Harrod, Kevin S, Xu, Fadi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian flu Biology and life sciences Blood Body temperature Carbon dioxide Carotid body Death Disease control Failure Fatalities Female Fluorescent Antibody Technique Gases Humans Hydroxylase Hypercapnia Hypercapnia - diagnosis Hypoxia Hypoxia - diagnosis Infections Influenza Influenza A Influenza A Virus, H5N1 Subtype - physiology Influenza, Human Laboratory animals Lungs Medicine and Health Sciences Mental depression Mice Mice, Inbred BALB C Mortality Neurons Nodose ganglion pH effects Respiration Respiratory failure Substance P Swine flu Tachypnea Tyrosine Tyrosine 3-monooxygenase Vagus nerve Ventilation Ventilatory behavior Viral infections Viremia Viruses
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