Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis
Elevated levels of advanced glycation end products (AGEs) within tissues may contribute to endothelial dysfunction, an early indicator of atherosclerosis. We aimed to investigate whether levels of skin AGEs could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysi...
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| creator | Wang, Chun-Cheng Wang, Yao-Chang Wang, Guei-Jane Shen, Ming-Yi Chang, Yen-Lin Liou, Show-Yih Chen, Hung-Chih Chang, Chiz-Tzung |
| description | Elevated levels of advanced glycation end products (AGEs) within tissues may contribute to endothelial dysfunction, an early indicator of atherosclerosis. We aimed to investigate whether levels of skin AGEs could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.
One hundred and nineteen uremic patients on hemodialysis and 57 control subjects with moderate-to-high cardiovascular risk factors and without chronic kidney disease (CKD) were enrolled. We used ultrasound to measure flow-mediated vasodilation (FMD). An AGE reader measured skin autoflurorescence (AF). We then compared differences in FMD and skin AF values between the two groups. The uremic subjects had significantly higher levels of skin AF (3.47±0.76 AU vs. 2.21±0.45 arbitrary units; P |
| doi_str_mv | 10.1371/journal.pone.0147771 |
| format | Article |
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One hundred and nineteen uremic patients on hemodialysis and 57 control subjects with moderate-to-high cardiovascular risk factors and without chronic kidney disease (CKD) were enrolled. We used ultrasound to measure flow-mediated vasodilation (FMD). An AGE reader measured skin autoflurorescence (AF). We then compared differences in FMD and skin AF values between the two groups. The uremic subjects had significantly higher levels of skin AF (3.47±0.76 AU vs. 2.21±0.45 arbitrary units; P<0.01) and significantly lower levels of FMD (4.79%±1.88% vs. 7.19%±2.17%; P<0.01) than the non-CKD subjects. After adjusting for all potential covariates, we found that skin AF level independently predicted FMD in both the hemodialysis and the non-CKD groups. In the hemodialysis group, skin AF ≥ 3.05 arbitrary units predicted abnormal FMD at a sensitivity of 87.9% and a specificity of 78.6% (P<0.01).
Skin AF could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0147771</identifier><identifier>PMID: 26809145</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Advanced glycosylation end products ; Aged ; Aged, 80 and over ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - etiology ; Atherosclerosis - metabolism ; Biology and Life Sciences ; Biomarkers - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular system ; Comparative analysis ; Complications and side effects ; Coronary vessels ; Demographic aspects ; Diabetes ; Dialysis ; Disease control ; Female ; Glycation End Products, Advanced ; Glycosylation ; Health risks ; Hemodialysis ; Hospitals ; Humans ; Hypertension ; Internal medicine ; Kidney diseases ; Laboratories ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Nephrology ; Peritoneal dialysis ; Physical Sciences ; Physiological aspects ; Plasma ; Prospective Studies ; Renal Dialysis ; Risk analysis ; Risk Factors ; Skin ; Skin - metabolism ; Tissues ; Tomography ; Ultrasonic imaging ; Ultrasound ; Uremia ; Vasodilation ; Vasodilation - physiology</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0147771-e0147771</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Wang et al 2016 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-f42dd9742f09e38238a42eaf72c650b1e6bb7973167dfd53f6c02688f13cd6533</citedby><cites>FETCH-LOGICAL-c692t-f42dd9742f09e38238a42eaf72c650b1e6bb7973167dfd53f6c02688f13cd6533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726548/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726548/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26809145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ashton, Nick</contributor><creatorcontrib>Wang, Chun-Cheng</creatorcontrib><creatorcontrib>Wang, Yao-Chang</creatorcontrib><creatorcontrib>Wang, Guei-Jane</creatorcontrib><creatorcontrib>Shen, Ming-Yi</creatorcontrib><creatorcontrib>Chang, Yen-Lin</creatorcontrib><creatorcontrib>Liou, Show-Yih</creatorcontrib><creatorcontrib>Chen, Hung-Chih</creatorcontrib><creatorcontrib>Chang, Chiz-Tzung</creatorcontrib><title>Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Elevated levels of advanced glycation end products (AGEs) within tissues may contribute to endothelial dysfunction, an early indicator of atherosclerosis. We aimed to investigate whether levels of skin AGEs could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.
One hundred and nineteen uremic patients on hemodialysis and 57 control subjects with moderate-to-high cardiovascular risk factors and without chronic kidney disease (CKD) were enrolled. We used ultrasound to measure flow-mediated vasodilation (FMD). An AGE reader measured skin autoflurorescence (AF). We then compared differences in FMD and skin AF values between the two groups. The uremic subjects had significantly higher levels of skin AF (3.47±0.76 AU vs. 2.21±0.45 arbitrary units; P<0.01) and significantly lower levels of FMD (4.79%±1.88% vs. 7.19%±2.17%; P<0.01) than the non-CKD subjects. After adjusting for all potential covariates, we found that skin AF level independently predicted FMD in both the hemodialysis and the non-CKD groups. In the hemodialysis group, skin AF ≥ 3.05 arbitrary units predicted abnormal FMD at a sensitivity of 87.9% and a specificity of 78.6% (P<0.01).
Skin AF could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.</description><subject>Adult</subject><subject>Advanced glycosylation end products</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - etiology</subject><subject>Atherosclerosis - metabolism</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular system</subject><subject>Comparative analysis</subject><subject>Complications and side effects</subject><subject>Coronary vessels</subject><subject>Demographic aspects</subject><subject>Diabetes</subject><subject>Dialysis</subject><subject>Disease control</subject><subject>Female</subject><subject>Glycation End Products, Advanced</subject><subject>Glycosylation</subject><subject>Health risks</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Internal medicine</subject><subject>Kidney diseases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Peritoneal dialysis</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Renal Dialysis</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Skin</subject><subject>Skin - metabolism</subject><subject>Tissues</subject><subject>Tomography</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Uremia</subject><subject>Vasodilation</subject><subject>Vasodilation - physiology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0eKv2MkNUjUGqzRpEmXcWq4_Whc37mwH6L_HodnUoF2gKEp08rzvyTk-pyheQjCFmMEPG9-FVrjpzrd6CiBhjMFHxSlsMJpQBPDjo_eT4lmMGwAqXFP6tDhBtAYNJNVpIRc_bFvOuuSN63zQUepW6nIey1mMXlqRtCp_2bQuL1rl01o7K1z5aR9N18pkfVtm-U3QWyvLRbfcaJlimaOXeutVRvfRxufFEyNc1C-G51lx8_ni2_nl5Or6y_x8djWRtEFpYghSqmEEGdBoXCNcC4K0MAxJWoEl1HS5ZA3DkDJlVIUNlSAXUhuIpaIVxmfF64PvzvnIh_5EDhkFAGFAe2J-IJQXG74LdivCnnth-d-ADysuQrLSaZ5zASK1AFJiorERCiJiGoMEpv2dvT4O2brlVqvctxSEG5mOv7R2zVf-JycM0YrU2eDdYBD8badj4lub2--caLXvDv_dIERpk9E3_6APVzdQK5ELsK3xOa_sTfmMEIhxhXBPTR-g8qX6Q8zDZGyOjwTvR4LMJP07rUQXI58vvv4_e_19zL49YtdauLSO3nX9VMUxSA6gDD7GoM19kyHg_S7cdYP3u8CHXciyV8cHdC-6G378B0UsBEY</recordid><startdate>20160125</startdate><enddate>20160125</enddate><creator>Wang, Chun-Cheng</creator><creator>Wang, Yao-Chang</creator><creator>Wang, Guei-Jane</creator><creator>Shen, Ming-Yi</creator><creator>Chang, Yen-Lin</creator><creator>Liou, Show-Yih</creator><creator>Chen, Hung-Chih</creator><creator>Chang, Chiz-Tzung</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160125</creationdate><title>Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis</title><author>Wang, Chun-Cheng ; Wang, Yao-Chang ; Wang, Guei-Jane ; Shen, Ming-Yi ; Chang, Yen-Lin ; Liou, Show-Yih ; Chen, Hung-Chih ; Chang, Chiz-Tzung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-f42dd9742f09e38238a42eaf72c650b1e6bb7973167dfd53f6c02688f13cd6533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Advanced glycosylation end products</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - etiology</topic><topic>Atherosclerosis - metabolism</topic><topic>Biology and Life Sciences</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular system</topic><topic>Comparative analysis</topic><topic>Complications and side effects</topic><topic>Coronary vessels</topic><topic>Demographic aspects</topic><topic>Diabetes</topic><topic>Dialysis</topic><topic>Disease control</topic><topic>Female</topic><topic>Glycation End Products, Advanced</topic><topic>Glycosylation</topic><topic>Health risks</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Internal medicine</topic><topic>Kidney diseases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Peritoneal dialysis</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Renal Dialysis</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Skin</topic><topic>Skin - metabolism</topic><topic>Tissues</topic><topic>Tomography</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Uremia</topic><topic>Vasodilation</topic><topic>Vasodilation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chun-Cheng</creatorcontrib><creatorcontrib>Wang, Yao-Chang</creatorcontrib><creatorcontrib>Wang, Guei-Jane</creatorcontrib><creatorcontrib>Shen, Ming-Yi</creatorcontrib><creatorcontrib>Chang, Yen-Lin</creatorcontrib><creatorcontrib>Liou, Show-Yih</creatorcontrib><creatorcontrib>Chen, Hung-Chih</creatorcontrib><creatorcontrib>Chang, Chiz-Tzung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Chun-Cheng</au><au>Wang, Yao-Chang</au><au>Wang, Guei-Jane</au><au>Shen, Ming-Yi</au><au>Chang, Yen-Lin</au><au>Liou, Show-Yih</au><au>Chen, Hung-Chih</au><au>Chang, Chiz-Tzung</au><au>Ashton, Nick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-01-25</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>e0147771</spage><epage>e0147771</epage><pages>e0147771-e0147771</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Elevated levels of advanced glycation end products (AGEs) within tissues may contribute to endothelial dysfunction, an early indicator of atherosclerosis. We aimed to investigate whether levels of skin AGEs could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.
One hundred and nineteen uremic patients on hemodialysis and 57 control subjects with moderate-to-high cardiovascular risk factors and without chronic kidney disease (CKD) were enrolled. We used ultrasound to measure flow-mediated vasodilation (FMD). An AGE reader measured skin autoflurorescence (AF). We then compared differences in FMD and skin AF values between the two groups. The uremic subjects had significantly higher levels of skin AF (3.47±0.76 AU vs. 2.21±0.45 arbitrary units; P<0.01) and significantly lower levels of FMD (4.79%±1.88% vs. 7.19%±2.17%; P<0.01) than the non-CKD subjects. After adjusting for all potential covariates, we found that skin AF level independently predicted FMD in both the hemodialysis and the non-CKD groups. In the hemodialysis group, skin AF ≥ 3.05 arbitrary units predicted abnormal FMD at a sensitivity of 87.9% and a specificity of 78.6% (P<0.01).
Skin AF could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26809145</pmid><doi>10.1371/journal.pone.0147771</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-01, Vol.11 (1), p.e0147771-e0147771 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Advanced glycosylation end products Aged Aged, 80 and over Arteriosclerosis Atherosclerosis Atherosclerosis - etiology Atherosclerosis - metabolism Biology and Life Sciences Biomarkers - metabolism Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Cardiovascular system Comparative analysis Complications and side effects Coronary vessels Demographic aspects Diabetes Dialysis Disease control Female Glycation End Products, Advanced Glycosylation Health risks Hemodialysis Hospitals Humans Hypertension Internal medicine Kidney diseases Laboratories Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Nephrology Peritoneal dialysis Physical Sciences Physiological aspects Plasma Prospective Studies Renal Dialysis Risk analysis Risk Factors Skin Skin - metabolism Tissues Tomography Ultrasonic imaging Ultrasound Uremia Vasodilation Vasodilation - physiology |
| title | Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T04%3A51%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Skin%20Autofluorescence%20Is%20Associated%20with%20Endothelial%20Dysfunction%20in%20Uremic%20Subjects%20on%20Hemodialysis&rft.jtitle=PloS%20one&rft.au=Wang,%20Chun-Cheng&rft.date=2016-01-25&rft.volume=11&rft.issue=1&rft.spage=e0147771&rft.epage=e0147771&rft.pages=e0147771-e0147771&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0147771&rft_dat=%3Cgale_plos_%3EA441335233%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1760023063&rft_id=info:pmid/26809145&rft_galeid=A441335233&rft_doaj_id=oai_doaj_org_article_bb704cea0cc34e3fad124f9f2a362a36&rfr_iscdi=true |