Two Chitotriose-Specific Lectins Show Anti-Angiogenesis, Induces Caspase-9-Mediated Apoptosis and Early Arrest of Pancreatic Tumor Cell Cycle

The antiproliferative activity of two chito-specific agglutinins purified from Benincasa hispida (BhL) and Datura innoxia (DiL9) of different plant family origin was investigated on various cancer cell lines. Both lectins showed chitotriose specificity, by inhibiting lectin hemagglutinating activity...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146110-e0146110
Hauptverfasser:	Singh, Ruby, Nawale, Laxman, Sarkar, Dhiman, Suresh, C G
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutinins Angiogenesis Angiogenesis Inhibitors - pharmacology Animals Anticancer properties Antineoplastic Agents, Phytogenic - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Autophagy Benincasa hispida Binding Biology and Life Sciences Breast cancer Calcium Calcium (intracellular) Cancer Cancer therapies Care and treatment Caspase Caspase 9 - metabolism Caspase-9 Cell activation Cell cycle Cell Cycle Checkpoints - drug effects Cell death Cell growth Cell Line, Tumor - drug effects Cell surface Chemotherapy Chromatography Cucurbitaceae - chemistry Cytochrome Datura - chemistry Datura innoxia Depolarization Diagnosis Drug Screening Assays, Antitumor - methods Endothelial cells Fibroblasts Human Umbilical Vein Endothelial Cells - drug effects Humans Laboratories Lectins Lectins - isolation & purification Lectins - pharmacology Legumes Medicine and Health Sciences Membrane potential Metastasis Mice Mitochondria Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Polysaccharides Radiation therapy Research and Analysis Methods Studies Trisaccharides - chemistry Trisaccharides - metabolism Tumor cell lines Umbilical vein
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