Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice

Uridine is a pyrimidine nucleoside that exerts restorative functions in tissues under stress. Short-term co-administration of uridine with multiple unrelated drugs prevents drug-induced liver lipid accumulation. Uridine has the ability to modulate liver metabolism; however, the precise mechanism has...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146994-e0146994
Hauptverfasser:	Urasaki, Yasuyo, Pizzorno, Giuseppe, Le, Thuc T
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Animal tissues Animals Biosynthesis Cancer Care and treatment Diabetes Diabetes mellitus Diabetic neuropathy Drugs Fatty acid-binding protein Fatty acids Fatty liver Fatty Liver - chemically induced Fatty Liver - metabolism Fatty Liver - pathology Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Gluconeogenesis Gluconeogenesis - drug effects Glucose Intolerance - chemically induced Glucose Intolerance - metabolism Glucose Intolerance - pathology Glucose tolerance Health sciences Hep G2 Cells Humans Immunoglobulins Insulin Insulin resistance Intolerance Laboratory animals Lipids Liver Liver diseases Long-term effects Metabolism Mice Microscopy Phosphorylation Prediabetic state Prediabetic State - chemically induced Prediabetic State - metabolism Prediabetic State - pathology Proteins Rodents Signaling Uridine Uridine - adverse effects Uridine - pharmacology
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