Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection
To evaluate changes in the concentrations of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in aqueous humor of patients with neovascular glaucoma (NVG) before and after an intravitreal injection of ranibizumab (IVR) and to determine the underlying correlation betwe...
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| creator | Zhou, Minwen Wang, Jiawei Wang, Wei Huang, Wenbin Ding, Xiaoyan Zhang, Xiulan |
| description | To evaluate changes in the concentrations of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in aqueous humor of patients with neovascular glaucoma (NVG) before and after an intravitreal injection of ranibizumab (IVR) and to determine the underlying correlation between the levels.
The prospective interventional comparative study involved 20 eyes of 20 patients with surgery-required advanced NVG and 20 control subjects from January 2013 to November 2013. The NVG eyes received the IVR treatment before glaucoma surgery. Aqueous humor was collected at the time of the IVR injection (pre- IVR) and at the time of antiglaucomatous surgery (post-IVR). Aqueous humor was also collected at the time of cataract surgery in normal control. Aqueous humor and plasma VEGF-A and PlGF levels were measured with an enzyme-linked immunosorbent assay methods, respectively.
The mean aqueous humor PlGF and VEGF-A concentrations in the pre-IVR eyes were significantly higher than in those of the control subjects (p |
| doi_str_mv | 10.1371/journal.pone.0146993 |
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The prospective interventional comparative study involved 20 eyes of 20 patients with surgery-required advanced NVG and 20 control subjects from January 2013 to November 2013. The NVG eyes received the IVR treatment before glaucoma surgery. Aqueous humor was collected at the time of the IVR injection (pre- IVR) and at the time of antiglaucomatous surgery (post-IVR). Aqueous humor was also collected at the time of cataract surgery in normal control. Aqueous humor and plasma VEGF-A and PlGF levels were measured with an enzyme-linked immunosorbent assay methods, respectively.
The mean aqueous humor PlGF and VEGF-A concentrations in the pre-IVR eyes were significantly higher than in those of the control subjects (p<0.001), whereas the plasma levels showed no significant difference. There was a statistically significant correlation between the aqueous humor PlGF and the VEGF-A concentration (r = 0.612, p = 0.003). The mean aqueous humor PlGF in the post-IVR eyes dramatically decreased from 1078.36 ± 755.83 to 177.64 ± 151.73 pg/mL (p<0.001). The VEGF-A level showed a similar trend from 3697.64 ± 2104.47 pg/mL to 183.54 ± 130.35 pg/mL (p<0.001).
Aqueous humor concentrations of VEGF-A and PlGF were significantly elevated in the eyes with NVG, and there was a positive correlation between the levels. After an IVR treatment, VEGF-A and PlGF were significantly decreased in NVG eyes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0146993</identifier><identifier>PMID: 26785251</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Aged ; Angiogenesis ; Aqueous Humor - metabolism ; Biology and Life Sciences ; Care and treatment ; Cataract Extraction ; Cataracts ; Comparative studies ; Correlation ; Diabetes ; Diabetic retinopathy ; Disease ; Dosage and administration ; Enzyme-linked immunosorbent assay ; Eye ; Eye surgery ; Female ; Glaucoma ; Glaucoma, Neovascular - drug therapy ; Glaucoma, Neovascular - metabolism ; Glaucoma, Neovascular - surgery ; Growth factors ; Health aspects ; Homeostasis ; Humans ; Hypertension ; Hypoxia ; Immunotherapy ; Injection ; Intravitreal Injections ; Laboratories ; Macular degeneration ; Male ; Medicine and Health Sciences ; Middle Aged ; Monoclonal antibodies ; Patient outcomes ; Patients ; Physiological aspects ; Placenta ; Placenta Growth Factor ; Plasma levels ; Pregnancy Proteins - blood ; Pregnancy Proteins - metabolism ; Prospective Studies ; Ranibizumab ; Ranibizumab - administration & dosage ; Ranibizumab - pharmacology ; Statistical analysis ; Studies ; Surgery ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0146993-e0146993</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Zhou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Zhou et al 2016 Zhou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8b9d05ab3003630cebc4c3975cf59e60a44f4247cd2e00a190a1f9fdf5d42e393</citedby><cites>FETCH-LOGICAL-c692t-8b9d05ab3003630cebc4c3975cf59e60a44f4247cd2e00a190a1f9fdf5d42e393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718677/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718677/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26785251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Duesbery, N.S.</contributor><creatorcontrib>Zhou, Minwen</creatorcontrib><creatorcontrib>Wang, Jiawei</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Huang, Wenbin</creatorcontrib><creatorcontrib>Ding, Xiaoyan</creatorcontrib><creatorcontrib>Zhang, Xiulan</creatorcontrib><title>Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate changes in the concentrations of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in aqueous humor of patients with neovascular glaucoma (NVG) before and after an intravitreal injection of ranibizumab (IVR) and to determine the underlying correlation between the levels.
The prospective interventional comparative study involved 20 eyes of 20 patients with surgery-required advanced NVG and 20 control subjects from January 2013 to November 2013. The NVG eyes received the IVR treatment before glaucoma surgery. Aqueous humor was collected at the time of the IVR injection (pre- IVR) and at the time of antiglaucomatous surgery (post-IVR). Aqueous humor was also collected at the time of cataract surgery in normal control. Aqueous humor and plasma VEGF-A and PlGF levels were measured with an enzyme-linked immunosorbent assay methods, respectively.
The mean aqueous humor PlGF and VEGF-A concentrations in the pre-IVR eyes were significantly higher than in those of the control subjects (p<0.001), whereas the plasma levels showed no significant difference. There was a statistically significant correlation between the aqueous humor PlGF and the VEGF-A concentration (r = 0.612, p = 0.003). The mean aqueous humor PlGF in the post-IVR eyes dramatically decreased from 1078.36 ± 755.83 to 177.64 ± 151.73 pg/mL (p<0.001). The VEGF-A level showed a similar trend from 3697.64 ± 2104.47 pg/mL to 183.54 ± 130.35 pg/mL (p<0.001).
Aqueous humor concentrations of VEGF-A and PlGF were significantly elevated in the eyes with NVG, and there was a positive correlation between the levels. After an IVR treatment, VEGF-A and PlGF were significantly decreased in NVG eyes.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Aqueous Humor - metabolism</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Cataract Extraction</subject><subject>Cataracts</subject><subject>Comparative studies</subject><subject>Correlation</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>Dosage and administration</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Eye</subject><subject>Eye surgery</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Neovascular - drug therapy</subject><subject>Glaucoma, Neovascular - metabolism</subject><subject>Glaucoma, Neovascular - surgery</subject><subject>Growth factors</subject><subject>Health aspects</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoxia</subject><subject>Immunotherapy</subject><subject>Injection</subject><subject>Intravitreal Injections</subject><subject>Laboratories</subject><subject>Macular degeneration</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Placenta Growth Factor</subject><subject>Plasma levels</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Proteins - metabolism</subject><subject>Prospective Studies</subject><subject>Ranibizumab</subject><subject>Ranibizumab - administration & dosage</subject><subject>Ranibizumab - pharmacology</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBEQkJw0eKvfPgGaRpbqTQxND5urRPnpHWVxp3tdIxfj8uyqUG7QJEV6_g5r-3X5yTJS0qmlBf0w8r2roN2urEdTgkVuZT8UXJIJWeTnBH-eG9-kDzzfkVIxss8f5ocsLwoM5bRw6T72oLGLkA6c_Y6LNMz0MG61HTp6Q369NrE2Be0W_C6b8GlsxZ6bdeQzn36CbVD8Fin0AR06bwLDrYmxGCbXkJnKvO7X0MVF1aog7Hd8-RJA63HF8P_KPlxdvr95PPk_GI2Pzk-n-hcsjApK1mTDCpOCM850VhpobksMt1kEnMCQjSCiULXDAkBKuNoZFM3WS0YcsmPkte3upvWejVY5RUtspIKWXARifktUVtYqY0za3A3yoJRfwPWLRS4YHSLqkLkKJsiGkVEzWgZzyMkLauKZU1V86j1cditr9ZY7_x00I5ExyudWaqF3SpR0DIviijwbhBw9qpHH9TaeI1tCx3afnfunJQFy0ge0Tf_oA_fbqAWEC9gusbGffVOVB0LQTLJKGWRmj5Axa_GtdGxrhoT46OE96OEyAT8FRbQe6_m3y7_n734OWbf7rHLWD5h6W3b70rGj0FxC2pnvXfY3JtMidq1xZ0batcWamiLmPZq_4Huk-76gP8B4s0I8A</recordid><startdate>20160119</startdate><enddate>20160119</enddate><creator>Zhou, Minwen</creator><creator>Wang, Jiawei</creator><creator>Wang, Wei</creator><creator>Huang, Wenbin</creator><creator>Ding, Xiaoyan</creator><creator>Zhang, Xiulan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160119</creationdate><title>Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection</title><author>Zhou, Minwen ; Wang, Jiawei ; Wang, Wei ; Huang, Wenbin ; Ding, Xiaoyan ; Zhang, Xiulan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8b9d05ab3003630cebc4c3975cf59e60a44f4247cd2e00a190a1f9fdf5d42e393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Aqueous Humor - metabolism</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Cataract Extraction</topic><topic>Cataracts</topic><topic>Comparative studies</topic><topic>Correlation</topic><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Disease</topic><topic>Dosage and administration</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Eye</topic><topic>Eye surgery</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Neovascular - drug therapy</topic><topic>Glaucoma, Neovascular - metabolism</topic><topic>Glaucoma, Neovascular - surgery</topic><topic>Growth factors</topic><topic>Health aspects</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypoxia</topic><topic>Immunotherapy</topic><topic>Injection</topic><topic>Intravitreal Injections</topic><topic>Laboratories</topic><topic>Macular degeneration</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Placenta</topic><topic>Placenta Growth Factor</topic><topic>Plasma levels</topic><topic>Pregnancy Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Minwen</au><au>Wang, Jiawei</au><au>Wang, Wei</au><au>Huang, Wenbin</au><au>Ding, Xiaoyan</au><au>Zhang, Xiulan</au><au>Duesbery, N.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-01-19</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>e0146993</spage><epage>e0146993</epage><pages>e0146993-e0146993</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate changes in the concentrations of placental growth factor (PlGF) and vascular endothelial growth factor-A (VEGF-A) in aqueous humor of patients with neovascular glaucoma (NVG) before and after an intravitreal injection of ranibizumab (IVR) and to determine the underlying correlation between the levels.
The prospective interventional comparative study involved 20 eyes of 20 patients with surgery-required advanced NVG and 20 control subjects from January 2013 to November 2013. The NVG eyes received the IVR treatment before glaucoma surgery. Aqueous humor was collected at the time of the IVR injection (pre- IVR) and at the time of antiglaucomatous surgery (post-IVR). Aqueous humor was also collected at the time of cataract surgery in normal control. Aqueous humor and plasma VEGF-A and PlGF levels were measured with an enzyme-linked immunosorbent assay methods, respectively.
The mean aqueous humor PlGF and VEGF-A concentrations in the pre-IVR eyes were significantly higher than in those of the control subjects (p<0.001), whereas the plasma levels showed no significant difference. There was a statistically significant correlation between the aqueous humor PlGF and the VEGF-A concentration (r = 0.612, p = 0.003). The mean aqueous humor PlGF in the post-IVR eyes dramatically decreased from 1078.36 ± 755.83 to 177.64 ± 151.73 pg/mL (p<0.001). The VEGF-A level showed a similar trend from 3697.64 ± 2104.47 pg/mL to 183.54 ± 130.35 pg/mL (p<0.001).
Aqueous humor concentrations of VEGF-A and PlGF were significantly elevated in the eyes with NVG, and there was a positive correlation between the levels. After an IVR treatment, VEGF-A and PlGF were significantly decreased in NVG eyes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26785251</pmid><doi>10.1371/journal.pone.0146993</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Aged Angiogenesis Aqueous Humor - metabolism Biology and Life Sciences Care and treatment Cataract Extraction Cataracts Comparative studies Correlation Diabetes Diabetic retinopathy Disease Dosage and administration Enzyme-linked immunosorbent assay Eye Eye surgery Female Glaucoma Glaucoma, Neovascular - drug therapy Glaucoma, Neovascular - metabolism Glaucoma, Neovascular - surgery Growth factors Health aspects Homeostasis Humans Hypertension Hypoxia Immunotherapy Injection Intravitreal Injections Laboratories Macular degeneration Male Medicine and Health Sciences Middle Aged Monoclonal antibodies Patient outcomes Patients Physiological aspects Placenta Placenta Growth Factor Plasma levels Pregnancy Proteins - blood Pregnancy Proteins - metabolism Prospective Studies Ranibizumab Ranibizumab - administration & dosage Ranibizumab - pharmacology Statistical analysis Studies Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood Vascular Endothelial Growth Factor A - metabolism |
| title | Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T04%3A15%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Placenta%20Growth%20Factor%20in%20Eyes%20with%20Neovascular%20Glaucoma%20Is%20Decreased%20after%20Intravitreal%20Ranibizumab%20Injection&rft.jtitle=PloS%20one&rft.au=Zhou,%20Minwen&rft.date=2016-01-19&rft.volume=11&rft.issue=1&rft.spage=e0146993&rft.epage=e0146993&rft.pages=e0146993-e0146993&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0146993&rft_dat=%3Cgale_plos_%3EA440592112%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1758149734&rft_id=info:pmid/26785251&rft_galeid=A440592112&rft_doaj_id=oai_doaj_org_article_bee3e9f7ace04d218ceb4918bb25fbd3&rfr_iscdi=true |