A Human Anti-Toll Like Receptor 4 Fab Fragment Inhibits Lipopolysaccharide-Induced Pro-Inflammatory Cytokines Production in Macrophages

The results of clinical and experimental studies suggest that endotoxin/toll-like receptor 4 (TLR4)-mediated proinflammatory and profibrotic signaling activation is critical in the development of hepatic fibrosis. However, studies examining the role of specific TLR4 inhibitor are still lacking. The...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0146856-e0146856
Hauptverfasser:	Wang, Maorong, Zheng, Wenkai, Zhu, Xuhui, Xu, Jing, Cai, Binggang, Zhang, Yiqing, Zheng, Feng, Zhou, Linfu, Yang, Zhiguo, Zhang, Xin, Wang, Changjun, Nie, Shinan, Zhu, Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antibody libraries Cell Line, Tumor Chains Cytokines Cytokines - genetics Cytokines - metabolism E coli Emergency medical care Enzyme-linked immunosorbent assay Escherichia coli Extracellular matrix Fab Fibrosis Gel electrophoresis Genetic aspects Hepatitis Hospitals Humans Immune system Immunoglobulin Fab Fragments - immunology Immunoglobulins Inflammation Inflammatory diseases Interleukin 1 Interleukin 6 Interleukin 8 Kinetics Lipopolysaccharides Lipopolysaccharides - toxicity Liver diseases Macrophages Macrophages - immunology Pathogens Phages Physiological aspects Proteins Rodents Signaling Sodium lauryl sulfate TLR4 protein Toll-Like Receptor 4 - immunology Toll-like receptors Tumor necrosis factor-TNF Tumor necrosis factor-α Western blotting
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