Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function

Acute, inflammatory conditions associated with dysregulated complement activation are characterized by significant increases in blood concentration of reactive oxygen species (ROS) and ATP. The mechanisms by which these molecules arise are not fully understood. In this study, using luminometric- and...

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Veröffentlicht in:	PloS one 2016-01, Vol.11 (1), p.e0141206-e0141206
Hauptverfasser:	Khoory, Joseph, Estanislau, Jessica, Elkhal, Abdallah, Lazaar, Asmae, Melhorn, Mark I, Brodsky, Abigail, Illigens, Ben, Hamachi, Itaru, Kurishita, Yasutaka, Ivanov, Alexander R, Shevkoplyas, Sergey, Shapiro, Nathan I, Ghiran, Ionita C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Adenosine Triphosphate - metabolism Anion Exchange Protein 1, Erythrocyte - metabolism Antibodies ATP Binding sites Blood Blood cells Blood levels Capillary flow Cascades Caspase Caspase 3 - metabolism Caspase-3 Cell activation Chemistry Cloning Complement activation Deformability Deformation mechanisms Endothelial cells Engineering schools Erythrocyte Membrane - metabolism Erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Fluorescence Fluorescence recovery after photobleaching Formability Glutathione Glycophorin - metabolism Humans Immune response Immunoglobulins Inflammation Innate immunity Lipid Metabolism Medical schools Microchannels NAD(P)H oxidase Oxidation-Reduction Oxidative stress Oxygen Phenotype Phosphorylation Photobleaching rac1 GTP-Binding Protein - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Red blood cells Sepsis
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