Lung Transplantation for Lymphangioleiomyomatosis in Japan
Lung transplantation has been established as the definitive treatment option for patients with advanced lymphangioleiomyomatosis (LAM). However, the prognosis after registration and the circumstances of lung transplantation with sirolimus therapy have never been reported. In this national survey, we...
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| creator | Ando, Katsutoshi Okada, Yoshinori Akiba, Miki Kondo, Takashi Kawamura, Tomohiro Okumura, Meinoshin Chen, Fengshi Date, Hiroshi Shiraishi, Takeshi Iwasaki, Akinori Yamasaki, Naoya Nagayasu, Takeshi Chida, Masayuki Inoue, Yoshikazu Hirai, Toyohiro Seyama, Kuniaki Mishima, Michiaki |
| description | Lung transplantation has been established as the definitive treatment option for patients with advanced lymphangioleiomyomatosis (LAM). However, the prognosis after registration and the circumstances of lung transplantation with sirolimus therapy have never been reported.
In this national survey, we analyzed data from 98 LAM patients registered for lung transplantation in the Japan Organ Transplantation Network.
Transplantation was performed in 57 patients as of March 2014. Survival rate was 86.7% at 1 year, 82.5% at 3 years, 73.7% at 5 years, and 73.7% at 10 years. Of the 98 patients, 21 had an inactive status and received sirolimus more frequently than those with an active history (67% vs. 5%, p |
| doi_str_mv | 10.1371/journal.pone.0146749 |
| format | Article |
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In this national survey, we analyzed data from 98 LAM patients registered for lung transplantation in the Japan Organ Transplantation Network.
Transplantation was performed in 57 patients as of March 2014. Survival rate was 86.7% at 1 year, 82.5% at 3 years, 73.7% at 5 years, and 73.7% at 10 years. Of the 98 patients, 21 had an inactive status and received sirolimus more frequently than those with an active history (67% vs. 5%, p<0.001). Nine of twelve patients who remained inactive as of March 2014 initiated sirolimus before or while on a waiting list, and remained on sirolimus thereafter. Although the statistical analysis showed no statistically significant difference, the survival rate after registration tended to be better for lung transplant recipients than for those who awaited transplantation (p = 0.053).
Lung transplantation is a satisfactory therapeutic option for advanced LAM, but the circumstances for pre-transplantation LAM patients are likely to alter with the use of sirolimus.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0146749</identifier><identifier>PMID: 26771878</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aging ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Cancer ; Care and treatment ; Data processing ; Disease ; Female ; Health aspects ; Heart ; Humans ; Japan ; Lung Neoplasms - surgery ; Lung Transplantation ; Lymphangioleiomyomatosis - surgery ; Lymphatic diseases ; Male ; Medicine ; Middle Aged ; Organ transplantation ; Patients ; Pediatrics ; Pulmonary arteries ; Rapamycin ; Retrospective Studies ; Sirolimus - administration & dosage ; Sirolimus - therapeutic use ; Statistical analysis ; Surgery ; Survival ; Survival Rate ; Thoracic surgery ; Transplantation ; Transplants & implants ; University graduates ; Young Adult</subject><ispartof>PloS one, 2016-01, Vol.11 (1), p.e0146749-e0146749</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Ando et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Ando et al 2016 Ando et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c736t-fd2880ff3769db9ce081aa77086a0809f7544289ca0263952fd5f6f130f7554b3</citedby><cites>FETCH-LOGICAL-c736t-fd2880ff3769db9ce081aa77086a0809f7544289ca0263952fd5f6f130f7554b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26771878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ando, Katsutoshi</creatorcontrib><creatorcontrib>Okada, Yoshinori</creatorcontrib><creatorcontrib>Akiba, Miki</creatorcontrib><creatorcontrib>Kondo, Takashi</creatorcontrib><creatorcontrib>Kawamura, Tomohiro</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><creatorcontrib>Chen, Fengshi</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Shiraishi, Takeshi</creatorcontrib><creatorcontrib>Iwasaki, Akinori</creatorcontrib><creatorcontrib>Yamasaki, Naoya</creatorcontrib><creatorcontrib>Nagayasu, Takeshi</creatorcontrib><creatorcontrib>Chida, Masayuki</creatorcontrib><creatorcontrib>Inoue, Yoshikazu</creatorcontrib><creatorcontrib>Hirai, Toyohiro</creatorcontrib><creatorcontrib>Seyama, Kuniaki</creatorcontrib><creatorcontrib>Mishima, Michiaki</creatorcontrib><creatorcontrib>Respiratory Failure Research Group of the Japanese Ministry of Health, Labour, and Welfare</creatorcontrib><title>Lung Transplantation for Lymphangioleiomyomatosis in Japan</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Lung transplantation has been established as the definitive treatment option for patients with advanced lymphangioleiomyomatosis (LAM). However, the prognosis after registration and the circumstances of lung transplantation with sirolimus therapy have never been reported.
In this national survey, we analyzed data from 98 LAM patients registered for lung transplantation in the Japan Organ Transplantation Network.
Transplantation was performed in 57 patients as of March 2014. Survival rate was 86.7% at 1 year, 82.5% at 3 years, 73.7% at 5 years, and 73.7% at 10 years. Of the 98 patients, 21 had an inactive status and received sirolimus more frequently than those with an active history (67% vs. 5%, p<0.001). Nine of twelve patients who remained inactive as of March 2014 initiated sirolimus before or while on a waiting list, and remained on sirolimus thereafter. Although the statistical analysis showed no statistically significant difference, the survival rate after registration tended to be better for lung transplant recipients than for those who awaited transplantation (p = 0.053).
Lung transplantation is a satisfactory therapeutic option for advanced LAM, but the circumstances for pre-transplantation LAM patients are likely to alter with the use of sirolimus.</description><subject>Adult</subject><subject>Aging</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Data processing</subject><subject>Disease</subject><subject>Female</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Humans</subject><subject>Japan</subject><subject>Lung Neoplasms - surgery</subject><subject>Lung Transplantation</subject><subject>Lymphangioleiomyomatosis - surgery</subject><subject>Lymphatic diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Organ transplantation</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Pulmonary arteries</subject><subject>Rapamycin</subject><subject>Retrospective Studies</subject><subject>Sirolimus - administration & dosage</subject><subject>Sirolimus - therapeutic use</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Thoracic surgery</subject><subject>Transplantation</subject><subject>Transplants & implants</subject><subject>University graduates</subject><subject>Young 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Takeshi</au><au>Chida, Masayuki</au><au>Inoue, Yoshikazu</au><au>Hirai, Toyohiro</au><au>Seyama, Kuniaki</au><au>Mishima, Michiaki</au><aucorp>Respiratory Failure Research Group of the Japanese Ministry of Health, Labour, and Welfare</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung Transplantation for Lymphangioleiomyomatosis in Japan</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>11</volume><issue>1</issue><spage>e0146749</spage><epage>e0146749</epage><pages>e0146749-e0146749</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Lung transplantation has been established as the definitive treatment option for patients with advanced lymphangioleiomyomatosis (LAM). However, the prognosis after registration and the circumstances of lung transplantation with sirolimus therapy have never been reported.
In this national survey, we analyzed data from 98 LAM patients registered for lung transplantation in the Japan Organ Transplantation Network.
Transplantation was performed in 57 patients as of March 2014. Survival rate was 86.7% at 1 year, 82.5% at 3 years, 73.7% at 5 years, and 73.7% at 10 years. Of the 98 patients, 21 had an inactive status and received sirolimus more frequently than those with an active history (67% vs. 5%, p<0.001). Nine of twelve patients who remained inactive as of March 2014 initiated sirolimus before or while on a waiting list, and remained on sirolimus thereafter. Although the statistical analysis showed no statistically significant difference, the survival rate after registration tended to be better for lung transplant recipients than for those who awaited transplantation (p = 0.053).
Lung transplantation is a satisfactory therapeutic option for advanced LAM, but the circumstances for pre-transplantation LAM patients are likely to alter with the use of sirolimus.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26771878</pmid><doi>10.1371/journal.pone.0146749</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2016-01, Vol.11 (1), p.e0146749-e0146749 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1757262372 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aging Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Cancer Care and treatment Data processing Disease Female Health aspects Heart Humans Japan Lung Neoplasms - surgery Lung Transplantation Lymphangioleiomyomatosis - surgery Lymphatic diseases Male Medicine Middle Aged Organ transplantation Patients Pediatrics Pulmonary arteries Rapamycin Retrospective Studies Sirolimus - administration & dosage Sirolimus - therapeutic use Statistical analysis Surgery Survival Survival Rate Thoracic surgery Transplantation Transplants & implants University graduates Young Adult |
| title | Lung Transplantation for Lymphangioleiomyomatosis in Japan |
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